Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Isabella Klein"'
Autor:
Michael Prattes, Irina Grishkovskaya, Victor-Valentin Hodirnau, Ingrid Rössler, Isabella Klein, Christina Hetzmannseder, Gertrude Zisser, Christian C. Gruber, Karl Gruber, David Haselbach, Helmut Bergler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The AAA-ATPase Drg1 is a key factor in eukaryotic ribosome biogenesis that initiates cytoplasmic maturation of the large subunit. Here the authors report the structure of Drg1 in complex with its specific inhibitor diazaborine and provide insight int
Externí odkaz:
https://doaj.org/article/122ec46f55d14062aec5a3b3ed2f1dd3
Autor:
Victor-Valentin Hodirnau, Gertrude Zisser, Ingrid Rössler, Christina Hetzmannseder, Karl Gruber, Christian Gruber, Irina Grishkovskaya, David Haselbach, Isabella Klein, Helmut Bergler, Michael Prattes
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
The hexameric AAA-ATPase Drg1 is a key factor in eukaryotic ribosome biogenesis and initiates cytoplasmic maturation of the large ribosomal subunit by releasing the shuttling maturation factor Rlp24. Drg1 monomers contain two AAA-domains (D1 and D2)
Autor:
Rebeca Medeiros, Adauto Barbosa, Pedro Barreto, Cíntia Sabino, Isabella Klein, Juliana Fernandes, Nayra Mazolli, Victor Ceotto, Maira Silva
Publikováno v:
Revista de Pediatria SOPERJ. 18:28-31
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1862:1491-1501
In the yeast Saccharomyces cerevisiae degradation of steryl esters is catalyzed by the steryl ester hydrolases Tgl1p, Yeh1p and Yeh2p. The two steryl ester hydrolases Tgl1p and Yeh1p localize to lipid droplets, a cell compartment storing steryl ester
Autor:
Heimo Wolinski, Uli Ohmayer, Helmut Bergler, Gertrude Zisser, Valentin Mitterer, Brigitte Pertschy, Christina Mauerhofer, Michael Prattes, Isabella Klein, Gerald N. Rechberger, Philipp Milkereit
Publikováno v:
Nucleic Acids Research
The formation of ribosomal subunits is a highly dynamic process that is initiated in the nucleus and involves more than 200 trans-acting factors, some of which accompany the pre-ribosomes into the cytoplasm and have to be recycled into the nucleus. T
Autor:
Isabella Klein, Francesca Di Bartolomeo, Thomas Becker, Kim Nguyen Doan, Ariane Wagner, Günther Daum, Claudia Hrastnik
Publikováno v:
Biochimica et biophysica acta. Molecular and cell biology of lipids. 1863(2)
Phosphatidylserine decarboxylase 1 (Psd1p) catalyzes the formation of the majority of phosphatidylethanolamine (PE) in the yeast Saccharomyces cerevisiae. Psd1p is localized to mitochondria, anchored to the inner mitochondrial membrane (IMM) through
Publikováno v:
Biochimica et biophysica acta. Molecular and cell biology of lipids. 1862(12)
Sterols are essential lipids of all eukaryotic cells, appearing either as free sterols or steryl esters. Besides other regulatory mechanisms, esterification of sterols and hydrolysis of steryl esters serve to buffer both an excess and a lack of free
Autor:
Gertrude Zisser, Mathias Loibl, Anna Gungl, Michael Prattes, Lisa Kappel, Claudia Schmidt, Elmar Krieger, Helmut Bergler, Brigitte Pertschy, Isabella Klein
Publikováno v:
Journal of Biological Chemistry, 289, 3913-22
Journal of Biological Chemistry, 289, 7, pp. 3913-22
Journal of Biological Chemistry, 289, 7, pp. 3913-22
Contains fulltext : 136109.pdf (Publisher’s version ) (Open Access) The drug diazaborine is the only known inhibitor of ribosome biogenesis and specifically blocks large subunit formation in eukaryotic cells. However, the target of this drug and th
Autor:
Helmut Bergler, Gerald N. Rechberger, Stefan Unterweger, Gertrude Zisser, Brigitte Pertschy, Isabella Klein, Gernot Fruhmann, Mathias Loibl, Christof Gruber, Lisa Kappel
Publikováno v:
The Journal of Cell Biology
Rlp24 recruits Drg1 to pre-60S particles and stimulates its ATP hydrolysis to promote downstream maturation through specific extraction of Rlp24.
Formation of eukaryotic ribosomes is driven by energy-consuming enzymes. The AAA-ATPase Drg1 is ess
Formation of eukaryotic ribosomes is driven by energy-consuming enzymes. The AAA-ATPase Drg1 is ess
Autor:
Isabella, Klein, Lisa, Klug, Claudia, Schmidt, Martina, Zandl, Martina, Korber, Günther, Daum, Karin, Athenstaedt
Publikováno v:
Molecular Biology of the Cell
Tgl4p and Tgl5p are two yeast lipid droplet proteins exhibiting triacylglycerol lipase and lysophospholipid acyltransferase activity. In the absence of lipid droplets, Tgl4p and Tgl5p are retained in the ER, where their properties change. Thus triacy