Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Isabella Garagiola"'
Autor:
Roberta Gualtierotti, Isabella Garagiola, Mimosa Mortarino, Silvia Spena, Olivia Romero-Lux, Flora Peyvandi
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
Hemophilia is a rare bleeding disorder caused by a genetic defect on chromosome X. It is inherited as an X-linked trait, and hence, it is more frequently diagnosed in males, whereas women have been traditionally considered only as carriers of the dis
Externí odkaz:
https://doaj.org/article/ac30fd956ed144da8aef1cd970f44ff3
Autor:
Silvia Spena, Andrea Cairo, Francesca Gianniello, Emanuela Pappalardo, Mimosa Mortarino, Isabella Garagiola, Ida Martinelli, Flora Peyvandi
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 14167 (2023)
High plasma levels of factor VIII (FVIII) and von Willebrand factor (VWF) have been indicated as independent risk factors for venous thromboembolism. However, the genetic factors responsible for their increase remain poorly known. In a large Italian
Externí odkaz:
https://doaj.org/article/72725f4835844be0b69de78277c79a98
Autor:
Sabine Eichinger, Pierre E. Morange, Marco Cattaneo, Mathilde Fretigny, Antoine Rauch, Astrid van Hylckama Vlieg, David-Alexandre Trégouët, Wolfram Ruf, Marcel Levi, José A. Páramo, Tom van der Poll, Paul A. Kyrle, Isabella Garagiola, Flora Peyvandi
Publikováno v:
HemaSphere, Vol 5, Iss 10, p e643 (2021)
Externí odkaz:
https://doaj.org/article/607db7a5722040f6a4a4234a06c35412
Autor:
Roberta Gualtierotti, Samantha Pasca, Alessandro Ciavarella, Sara Arcudi, Andrea Giachi, Isabella Garagiola, Chiara Suffritti, Simona Maria Siboni, Flora Peyvandi
Publikováno v:
Pharmaceuticals, Vol 15, Iss 10, p 1183 (2022)
Over the last decade, the world of hemophilia has experienced an unprecedented therapeutic advance, thanks to the progress in bioengineering technologies, leading to the introduction of drugs with novel mechanisms of action based on restoring thrombi
Externí odkaz:
https://doaj.org/article/29ab92324b324284b30400629c43f5a8
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
The most severe side effect of hemophilia treatment is the inhibitor development occurring in 30% of patients, during the earliest stages of treatment with factor (F)VIII concentrates. These catastrophic immune responses rapidly inactivate the infuse
Externí odkaz:
https://doaj.org/article/df99a32879254b89a796339fa951a343
Autor:
Raimondo De Cristofaro, Monica Sacco, Stefano Lancellotti, Federico Berruti, Isabella Garagiola, Carla Valsecchi, Maria Basso, Enrico Di Stasio, Flora Peyvandi
Publikováno v:
TH Open, Vol 03, Iss 02, Pp e123-e131 (2019)
Abstract Background Recombinant (rec-) coagulation factor VIII concentrates available for hemophilia A (HA) treatment differ in cell line production and structure, which could affect their pharmacodynamics and immunogenicity. Clinical trials showed
Externí odkaz:
https://doaj.org/article/8e7f8317cb9b48449edf9a93df810bf3
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 2001 (2021)
Hemophilia is an X-linked recessive bleeding disorder. In pregnant women carrier of hemophilia, the fetal sex can be determined by non-invasive analysis of fetal DNA circulating in the maternal blood. However, in case of a male fetus, conventional in
Externí odkaz:
https://doaj.org/article/5d819db205984828afe535cf907f802f
Autor:
Irving Donadon, John H. McVey, Isabella Garagiola, Alessio Branchini, Mimosa Mortarino, Flora Peyvandi, Francesco Bernardi, Mirko Pinotti
Publikováno v:
Haematologica, Vol 103, Iss 2 (2018)
Dissection of pleiotropic effects of missense mutations, rarely investigated in inherited diseases, is fundamental to understanding genotype-phenotype relationships. Missense mutations might impair mRNA processing in addition to protein properties. A
Externí odkaz:
https://doaj.org/article/3dc64b765cb24e64b98870bd571ecdc8
Autor:
Raffaella Rossio, Luca Andrea Lotta, Silvia Pontiggia, Nicolò Ghiringhelli Borsa, Isabella Garagiola, Gianluigi Ardissino, Danijela Mikovic, Massimo Cugno, Flora Peyvandi
Publikováno v:
Haematologica, Vol 100, Iss 3 (2015)
Externí odkaz:
https://doaj.org/article/3054a35e73ef4caeacdd991747d65645
Autor:
Roberta Palla, Silvia Lavoretano, Rossana Lombardi, Isabella Garagiola, Mehran Karimi, Abdolreza Afrasiabi, Mani Ramzi, Raimondo De Cristofaro, Flora Peyvandi
Publikováno v:
Haematologica, Vol 94, Iss 2 (2009)
The inherited deficiency of ADAMTS13 is usually associated with severe forms of thrombotic thrombocytopenic purpura. Among the mutations identified in the ADAMTS13 gene, none have been described on the TSP1-6 repeat domain. We investigated an Iranian
Externí odkaz:
https://doaj.org/article/7e2bfe6d5f9547d8add3becb4e46b0ee