Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Isabella Finco"'
Autor:
Dipika R. Mohan, Kleiton S. Borges, Isabella Finco, Christopher R. LaPensee, Juilee Rege, April L. Solon, Donald W. Little, Tobias Else, Madson Q. Almeida, Derek Dang, James Haggerty-Skeans, April A. Apfelbaum, Michelle Vinco, Alda Wakamatsu, Beatriz M. P. Mariani, Larissa Costa. Amorim, Ana Claudia. Latronico, Berenice B. Mendonca, Maria Claudia N. Zerbini, Elizabeth R. Lawlor, Ryoma Ohi, Richard J. Auchus, William E. Rainey, Suely K.N. Marie, Thomas J. Giordano, Sriram Venneti, Maria Candida Barisson Villares Fragoso, David T. Breault, Antonio Marcondes. Lerario, Gary D. Hammer
Publikováno v:
Cancer Research.
Adrenocortical carcinoma (ACC) is a rare cancer in which tissue-specific differentiation is paradoxically associated with dismal outcomes. The differentiated ACC subtype CIMP-high is prevalent, incurable, and routinely fatal. CIMP-high ACC possess ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be9890ecf1e233fe62894cabb8c7c08c
https://doi.org/10.1158/0008-5472.can-22-2712
https://doi.org/10.1158/0008-5472.can-22-2712
β-catenin programs a tissue-specific epigenetic vulnerability in aggressive adrenocortical carcinoma
Autor:
Dipika R. Mohan, Kleiton S. Borges, Isabella Finco, Christopher R. LaPensee, Juilee Rege, April L. Solon, Donald W. Little, Tobias Else, Madson Q. Almeida, Derek Dang, James Haggerty-Skeans, April A. Apfelbaum, Michelle Vinco, Alda Wakamatsu, Beatriz MP Mariani, Larissa Amorin, Ana Claudia Latronico, Berenice B. Mendonca, Maria Claudia N. Zerbini, Elizabeth R. Lawlor, Ryoma Ohi, Richard J. Auchus, William E. Rainey, Suely K. N. Marie, Thomas J. Giordano, Sriram Venneti, Maria Candida B. V. Fragoso, David T. Breault, Antonio Marcondes Lerario, Gary D. Hammer
Adrenocortical carcinoma (ACC) is a rare cancer in which tissue-specific differentiation is paradoxically associated with dismal outcomes. The differentiated ACC subtype CIMP-high is prevalent, incurable, and routinely fatal. CIMP-high ACC possess ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9810854af32882553cc7a6cfe3b60b1e
https://doi.org/10.1101/2022.07.02.497654
https://doi.org/10.1101/2022.07.02.497654
Autor:
Dipika R. Mohan, Kleiton S. Borges, Isabella Finco, Christopher R. LaPensee, Juilee Rege, Donald W. Little, Tobias Else, Madson Q. Almeida, Derek Dang, James Haggerty-Skeans, Ana Claudia Latronico, Berenice B. Mendonca, Richard J. Auchus, William E. Rainey, Suely K. Marie, Thomas J. Giordano, Sriram Venneti, Maria Candida B. Fragoso, David T. Breault, Antonio M. Lerario, Gary D. Hammer
Publikováno v:
Cancer Research. 83:1501-1501
Adrenocortical carcinoma (ACC) is a rare cancer of the adrenal cortex without curative medical therapies. CIMP-high is an aggressive ACC molecular subtype defined by global CpG island hypermethylation with paradoxical activation of adrenal differenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::089c1fa715cd4f01e3e83126f29d3e12
https://doi.org/10.1158/1538-7445.am2023-1501
https://doi.org/10.1158/1538-7445.am2023-1501
Autor:
Dipika Mohan, Kleiton Borges, Isabella Finco, Christopher LaPensee, Juilee Rege, Donald Little, Tobias Else, Madson Almeida, Ana Claudia Latronico, Berenice Mendonca, Richard Auchus, William Rainey, Suely Marie, Thomas Giordano, Sriram Venneti, Maria Candida Fragoso, David Breault, Antonio Lerario, Gary Hammer
Publikováno v:
Journal of the Endocrine Society. 6:A136-A136
Adrenocortical carcinoma (ACC) is a rare, aggressive, and poorly understood cancer of the adrenal cortex. Abnormal epigenetic patterning is a major predictor of dismal disease outcomes. Patients with genome-wide CpG island hypermethylation (CIMP-high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06232ef3330e4819c469c417acbeef67
https://doi.org/10.1210/jendso/bvac150.277
https://doi.org/10.1210/jendso/bvac150.277
Publikováno v:
Curr Opin Endocr Metab Res
The adrenal cortex is an endocrine organ comprised of three histological zones, the outermost zona glomerulosa, the intermediate zona fasciculata, and the innermost zona reticularis. High plasticity of the adrenal gland is supported by pools of stem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7324de53daeba325264403dea6ea657c
https://pubmed.ncbi.nlm.nih.gov/32258821
https://pubmed.ncbi.nlm.nih.gov/32258821
Autor:
Tobias Else, Christopher R. LaPensee, Berenice B. Mendonca, Michelle Vinco, Dipika R. Mohan, William E. Rainey, Alda Wakamatsu, Madson Q. Almeida, Ana Claudia Latronico, Suely Kazue Nagahashi Marie, Isabella Finco, Gary D. Hammer, Maria Candida Barisson Villares Fragoso, Maria Claudia Nogueira Zerbini, Antonio M. Lerario, Sriram Venneti, Juilee Rege, Thomas J. Giordano
Publikováno v:
Journal of the Endocrine Society
Adrenocortical carcinoma (ACC) is a rare, aggressive cancer. Up to 75% of patients develop incurable metastatic disease, highlighting an urgent need for novel medical therapies. We recently identified a rapidly progressive ACC subtype characterized b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::499fc30b5a0d3a52052c95e1b5a73071
https://doi.org/10.1210/jendso/bvaa046.2265
https://doi.org/10.1210/jendso/bvaa046.2265
Publikováno v:
Endocrinology. 159:579-596
The atrophy and hypofunction of the adrenal cortex following long-term pharmacologic glucocorticoid therapy is a major health problem necessitating chronic glucocorticoid replacement that often prolongs the ultimate return of endogenous adrenocortica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6211a9d5548825b56f7000400044dbc
https://doi.org/10.1210/en.2017-03061
https://doi.org/10.1210/en.2017-03061
Publikováno v:
Curr Opin Endocr Metab Res
Adrenocortical carcinoma (ACC) is a rare, aggressive, and frequently deadly cancer. Up to 75% of all patients will eventually develop metastatic disease, and our current medical therapies for ACC provide limited - if any - survival benefit. These sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e4f39ea232292cf5b15aae99c069abf
https://europepmc.org/articles/PMC7133705/
https://europepmc.org/articles/PMC7133705/
Autor:
Isabella Finco, Gary D. Hammer
Publikováno v:
J Vis Exp
Immunofluorescence is a well-established technique for detection of antigens in tissues with the employment of fluorochrome-conjugated antibodies and has a broad spectrum of applications. Detection of antigens allows for characterization and identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce53e9f642f58d85418e42079cf3d88
https://doi.org/10.3791/58530-v
https://doi.org/10.3791/58530-v
Publikováno v:
Annual Review of Physiology. 77:105-129
Since its discovery nearly 30 years ago, the Hedgehog (Hh) signaling pathway has been shown to be pivotal in many developmental and pathophysiological processes in several steroidogenic tissues, including the testis, ovary, adrenal cortex, and placen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::916a0f5234c739b144e75b4ca9495d34
https://doi.org/10.1146/annurev-physiol-061214-111754
https://doi.org/10.1146/annurev-physiol-061214-111754