Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Isabella, Provenzale"'
Autor:
Jingnan Huang, Frauke Swieringa, Fiorella A. Solari, Isabella Provenzale, Luigi Grassi, Ilaria De Simone, Constance C. F. M. J. Baaten, Rachel Cavill, Albert Sickmann, Mattia Frontini, Johan W. M. Heemskerk
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Novel platelet and megakaryocyte transcriptome analysis allows prediction of the full or theoretical proteome of a representative human platelet. Here, we integrated the established platelet proteomes from six cohorts of healthy subjects, en
Externí odkaz:
https://doaj.org/article/98b564f1b944467ca88a30f85c123905
Autor:
Delia I. Fernández, Isabella Provenzale, Hilaire Y.F. Cheung, Jan van Groningen, Bibian M.E. Tullemans, Alicia Veninga, Joanne L. Dunster, Saman Honarnejad, Helma van den Hurk, Marijke J.E. Kuijpers, Johan W.M. Heemskerk
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103718- (2022)
Summary: Antiplatelet drugs targeting G-protein-coupled receptors (GPCRs), used for the secondary prevention of arterial thrombosis, coincide with an increased bleeding risk. Targeting ITAM-linked receptors, such as the collagen receptor glycoprotein
Externí odkaz:
https://doaj.org/article/41f61631ed79476488c1835c6a7c8eef
Autor:
Isabella Provenzale, Sanne L. N. Brouns, Paola E. J. van der Meijden, Frauke Swieringa, Johan W. M. Heemskerk
Publikováno v:
Micromachines, Vol 10, Iss 11, p 787 (2019)
Microfluidic assays are versatile tests which, using only small amounts of blood, enable high throughput analyses of platelet function in several minutes. In combination with fluorescence microscopy, these flow tests allow real-time visualisation of
Externí odkaz:
https://doaj.org/article/05e596f9b6de48d1b708bb7193e5f9c2
Autor:
Sanne L. N. Brouns, Johan W. M. Heemskerk, Johanna P. van Geffen, Isabella Provenzale, Paola E. J. van der Meijden
Publikováno v:
Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis, 18(4), 931-941. Wiley
Journal of Thrombosis and Haemostasis, 18(4), 931-941. Wiley
Background In the intact vessel wall, endothelial cells form a barrier between the blood and the remaining vascular structures, serving to maintain blood fluidity and preventing platelet activation and fibrin clot formation. The spatiotemporal space
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a050a5846fc6ed3c28f11029e26532
https://doi.org/10.1111/jth.14719
https://doi.org/10.1111/jth.14719
Autor:
Delia I, Fernández, Isabella, Provenzale, Hilaire Y F, Cheung, Jan, van Groningen, Bibian M E, Tullemans, Alicia, Veninga, Joanne L, Dunster, Saman, Honarnejad, Helma, van den Hurk, Marijke J E, Kuijpers, Johan W M, Heemskerk
Publikováno v:
iScience
Summary Antiplatelet drugs targeting G-protein-coupled receptors (GPCRs), used for the secondary prevention of arterial thrombosis, coincide with an increased bleeding risk. Targeting ITAM-linked receptors, such as the collagen receptor glycoprotein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f97c2fe61bab3374cc750d4a5247af7c
https://pubmed.ncbi.nlm.nih.gov/35072010
https://pubmed.ncbi.nlm.nih.gov/35072010
Autor:
Paola E. J. van der Meijden, Gina Perrella, Jingnan Huang, Mark Roest, Floor C J I Heubel-Moenen, Isabella Provenzale, Richard W. Farndale, Robert A. S. Ariëns, Steve P. Watson, Frauke Swieringa, Martine Jandrot-Perrus, Mark R Thomas, Johan W. M. Heemskerk
Publikováno v:
Arteriosclerosis Thrombosis and Vascular Biology, 41(2), E97-E111. LIPPINCOTT WILLIAMS & WILKINS
Arteriosclerosis, Thrombosis, and Vascular Biology
Arteriosclerosis, Thrombosis, and Vascular Biology
Objective: Fibrin is considered to strengthen thrombus formation via integrin αIIbβ3, but recent findings indicate that fibrin can also act as ligand for platelet glycoprotein VI. Approach and Results: To investigate the thrombus-forming potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74f26a6d08bdabcee5c766256b6a5d4
https://doi.org/10.1161/atvbaha.120.314641
https://doi.org/10.1161/atvbaha.120.314641
Autor:
Ilaria De Simone, Mattia Frontini, Luigi Grassi, Isabella Provenzale, Rachel Cavill, Constance C.F.M.J. Baaten, Fiorella A. Solari, Jingnan Huang, Albert Sickmann, Johan W. M. Heemskerk, Frauke Swieringa
Publikováno v:
Scientific reports 11, 12358 (2021). doi:10.1038/s41598-021-91661-x
Scientific Reports
Scientific Reports, 11(1):12358. Nature Publishing Group
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Scientific Reports
Scientific Reports, 11(1):12358. Nature Publishing Group
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Scientific reports 11, 12358 (2021). doi:10.1038/s41598-021-91661-x
Published by Macmillan Publishers Limited, part of Springer Nature, [London]
Published by Macmillan Publishers Limited, part of Springer Nature, [London]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453dba9f0324faec5ebad4d69f09e65a
https://publications.rwth-aachen.de/record/845998
https://publications.rwth-aachen.de/record/845998
Autor:
Sanne L. N. Brouns, Elisabetta Castoldi, Isabella Provenzale, Remco Verdoold, Henri M. H. Spronk, Johan W. M. Heemskerk, Paolo Simioni, Rachel Cavill, Marijke J E Kuijpers, Luca Spiezia, Frauke Swieringa, Paola E. J. van der Meijden, Elena Campello, Rene van Oerle, Richard W. Farndale, Johanna P. van Geffen, Kenneth J. Clemetson
Publikováno v:
Brouns, Sanne L N; van Geffen, Johanna P; Campello, Elena; Swieringa, Frauke; Spiezia, Luca; van Oerle, René; Provenzale, Isabella; Verdoold, Remco; Farndale, Richard W; Clemetson, Kenneth J.; Spronk, Henri M H; van der Meijden, Paola E J; Cavill, Rachel; Kuijpers, Marijke J E; Castoldi, Elisabetta; Simioni, Paolo; Heemskerk, Johan W M (2020). Platelet-primed interactions of coagulation and anticoagulation pathways in flow-dependent thrombus formation. Scientific reports, 10(1), p. 11910. Springer Nature 10.1038/s41598-020-68438-9
Scientific Reports
Scientific Reports, 10(1):11910. Nature Publishing Group
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports, 10(1):11910. Nature Publishing Group
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
In haemostasis and thrombosis, platelet, coagulation and anticoagulation pathways act together to produce fibrin-containing thrombi. We developed a microspot-based technique, in which we assessed platelet adhesion, platelet activation, thrombus struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e527b16d5afc334757061015796cd2d3
https://www.repository.cam.ac.uk/handle/1810/308080
https://www.repository.cam.ac.uk/handle/1810/308080
Autor:
Marijke J.E. Kuijpers, Johan W. M. Heemskerk, Rachel Cavill, Delia I. Fernandez, Ilaria De Simone, Hugo ten Cate, Natalie J Jooss, Richard W. Farndale, Isabella Provenzale, Paola E. J. van der Meijden, Yvonne M. C. Henskens, Sanne L. N. Brouns
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 11
International journal of molecular sciences, 20(11):2788. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 20, Iss 11, p 2788 (2019)
Volume 20
Issue 11
International journal of molecular sciences, 20(11):2788. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 20, Iss 11, p 2788 (2019)
Platelet interaction with collagens, via von Willebrand factor, is a potent trigger of shear-dependent thrombus formation mediated by subsequent engagement of the signaling collagen receptor glycoprotein (GP)VI, enforced by integrin &alpha
2&bet
2&bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd1ed122fa3f16030b7b34c18824e2fa