Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Isabell Kemker"'
Autor:
Rebecca C. Feiner, Isabell Kemker, Lea Krutzke, Ellen Allmendinger, Daniel J. Mandell, Norbert Sewald, Stefan Kochanek, Kristian M. Müller
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 24, p 9535 (2020)
The epidermal growth factor receptor (EGFR) plays a central role in the progression of many solid tumors. We used this validated target to analyze the de novo design of EGFR-binding peptides and their application for the delivery of complex payloads
Externí odkaz:
https://doaj.org/article/6d9107ef918a4d15bf79a9a441e288d6
Autor:
Silvia Panzeri, Daniela Arosio, Silvia Gazzola, Laura Belvisi, Monica Civera, Donatella Potenza, Francesca Vasile, Isabell Kemker, Thomas Ertl, Norbert Sewald, Oliver Reiser, Umberto Piarulli
Publikováno v:
Molecules, Vol 25, Iss 24, p 5966 (2020)
Integrin ligands containing the tripeptide sequences Arg-Gly-Asp (RGD) and iso-Asp-Gly- Arg (isoDGR) were actively investigated as inhibitors of tumor angiogenesis and directing unit in tumor-targeting drug conjugates. Reported herein is the synthesi
Externí odkaz:
https://doaj.org/article/81d3836bab5b4d81a04af9dfb7615e4e
Publikováno v:
ARKIVOC, Vol 2015, Iss 2, Pp 10-19 (2014)
Externí odkaz:
https://doaj.org/article/3a22f84625ee4c6bb80f27acdf4c2ccb
Autor:
Carina Dargel, Ramsia Geisler, Yvonne Hannappel, Isabell Kemker, Norbert Sewald, Thomas Hellweg
Publikováno v:
Colloids and Interfaces, Vol 3, Iss 2, p 47 (2019)
This work investigates the temperature-dependent micelle formation as well as the micellar structure of the saponin aescin. The critical micelle concentration ( c m c ) of aescin is determined from the concentration-dependent autofluorescence (AF) of
Externí odkaz:
https://doaj.org/article/9220f43c8ca548fb92f80f152dba0b66
Autor:
Adina Borbély, Eduard Figueras, Ana Martins, Simone Esposito, Giulio Auciello, Edith Monteagudo, Annalise Di Marco, Vincenzo Summa, Paola Cordella, Raffaella Perego, Isabell Kemker, Marcel Frese, Paola Gallinari, Christian Steinkühler, Norbert Sewald
Publikováno v:
Pharmaceutics, Vol 11, Iss 4, p 151 (2019)
Cryptophycins are potent tubulin polymerization inhibitors with picomolar antiproliferative potency in vitro and activity against multidrug-resistant (MDR) cancer cells. Because of neurotoxic side effects and limited efficacy in vivo, cryptophycin-52
Externí odkaz:
https://doaj.org/article/8e55442c453b47dfb515e3a4632fb51a
Autor:
Rebecca C. Feiner, David C. Schröder, Antoine Marion, Norbert Sewald, Isabell Kemker, Kristian M. Müller
Publikováno v:
Journal of Medicinal Chemistry. 64:586-601
An array of l- and d-halotryptophans with different substituents at the indole moiety was synthesized employing either enzymatic halogenation by halogenases or incorporation of haloindoles using tryptophan synthase. Introduction of these Trp derivati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1771d700ac252daab0af281815a9e64
https://doi.org/10.1021/acs.jmedchem.0c01536
https://doi.org/10.1021/acs.jmedchem.0c01536
Autor:
Isabell Kemker, Elmira Ghabraie, Verónica I. Dodero, Nicolo Tonali, Norbert Sewald, Mohamed Ismail
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
Cyclic RGD peptides are well‐known ligands of integrins. The integrins αVβ3 and α5β1 are involved in angiogenesis, and integrin αVβ3 is abundantly present on cancer cells, thus representing a therapeutic target. Hence, synthetic and biophysic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d612be1e069089b0317d158f107de7aa
http://europepmc.org/articles/PMC7540173
http://europepmc.org/articles/PMC7540173
Publikováno v:
ACS Catalysis. 9:1149-1158
Tryptophan (Trp) derivatives constitute important building blocks found in many natural products, peptides, and drugs. Accordingly, there is a high demand for suitable biocatalytic pathways providing selective derivatization of Trp like C-H functiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c419b772a9c2ee1a7fc7a90113515d73
https://doi.org/10.1021/acscatal.8b04944
https://doi.org/10.1021/acscatal.8b04944
Autor:
Isabell Kemker, Eduard Figueras, Norbert Sewald, Carmela Michalek, Michele Anselmi, Luca Gentilucci, Adina Borbély
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
Most anticancer agents are hydrophobic and can easily penetrate the tumor cell membrane by passive diffusion. This may impede the development of highly effective and tumor‐selective treatment options. A hydrophilic β‐glucuronidase‐cleavable li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea53fff1eb94fff7277797c7528b78c
https://doi.org/10.1002/chem.202003471
https://doi.org/10.1002/chem.202003471
Autor:
Laura Belvisi, Francesca Vasile, Donatella Potenza, Daniela Arosio, Silvia Panzeri, Umberto Piarulli, Monica Civera, Thomas Ertl, Norbert Sewald, Isabell Kemker, Oliver Reiser, Silvia Gazzola
Publikováno v:
Molecules
Volume 25
Issue 24
Molecules, Vol 25, Iss 5966, p 5966 (2020)
Molecules (Basel, Online) 25 (2020). doi:10.3390/molecules25245966
info:cnr-pdr/source/autori:Panzeri Silvia, Arosio Daniela, Gazzola Silvia, Belvisi Laura, Civera Monica, Potenza Donatella, Vasile Francesca, Kemker Isabell, Ertl Thomas, Sewald Norbert, Reiser Oliver, Piarulli Umberto./titolo:Cyclic RGD and iso DGR Integrin Ligands Containing cis-2-amino-1-cyclopentanecarboxylic ( cis-Beta-ACPC) Scaffolds/doi:10.3390%2Fmolecules25245966/rivista:Molecules (Basel, Online)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:25
Volume 25
Issue 24
Molecules, Vol 25, Iss 5966, p 5966 (2020)
Molecules (Basel, Online) 25 (2020). doi:10.3390/molecules25245966
info:cnr-pdr/source/autori:Panzeri Silvia, Arosio Daniela, Gazzola Silvia, Belvisi Laura, Civera Monica, Potenza Donatella, Vasile Francesca, Kemker Isabell, Ertl Thomas, Sewald Norbert, Reiser Oliver, Piarulli Umberto./titolo:Cyclic RGD and iso DGR Integrin Ligands Containing cis-2-amino-1-cyclopentanecarboxylic ( cis-Beta-ACPC) Scaffolds/doi:10.3390%2Fmolecules25245966/rivista:Molecules (Basel, Online)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:25
Integrin ligands containing the tripeptide sequences Arg-Gly-Asp (RGD) and iso-Asp-Gly- Arg (isoDGR) were actively investigated as inhibitors of tumor angiogenesis and directing unit in tumor-targeting drug conjugates. Reported herein is the synthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5bbb1ab6eeb4e22c99334105c1c773