CD73-dependent generation of extracellular adenosine by vascular endothelial cells modulates de novo lipogenesis in adipose tissue

Autor: Michelle Y. Jaeckstein, Isabell Schulze, Michael Wolfgang Zajac, Markus Heine, Oliver Mann, Alexander Pfeifer, Joerg Heeren

Publikováno v: Frontiers in Immunology, Vol 14 (2024)

Next to white and brown adipocytes present in white and brown adipose tissue (WAT, BAT), vascular endothelial cells, tissue-resident macrophages and other immune cells have important roles in maintaining adipose tissue homeostasis but also contribute

Externí odkaz: https://doaj.org/article/a3c18f1e0f9f4b0997e75595158ef373

99 T cell immunotherapies trigger neutrophil activation to eliminate tumor antigen escape variants

Autor: Katherine Panageas, Taha Merghoub, Sadna Budhu, Billel Gasmi, Cailian Liu, Sara Schad, Jacob Ricca, Mathieu Gigoux, Levi Mangarin, David Redmond, David Schroder, Andrew Chow, Daniel Hirschhorn, Lukas kraehenbuehl, Anne-Laurent Flammar, Isabell Schulze, Olivier De Henau, Czrina Cortez, Aliya Holland, Asrhi Arora, Gabrielle Rizzuto, Jean Albrengues, Mikala Egeblad

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

Externí odkaz: https://doaj.org/article/605e061898584607bae1dc64228c85d1

Fundamental immune–oncogenicity trade-offs define driver mutation fitness

Autor: David Hoyos, Roberta Zappasodi, Isabell Schulze, Zachary Sethna, Kelvin César de Andrade, Dean F. Bajorin, Chaitanya Bandlamudi, Margaret K. Callahan, Samuel A. Funt, Sine R. Hadrup, Jeppe S. Holm, Jonathan E. Rosenberg, Sohrab P. Shah, Ignacio Vázquez-García, Britta Weigelt, Michelle Wu, Dmitriy Zamarin, Laura F. Campitelli, Edward J. Osborne, Mark Klinger, Harlan S. Robins, Payal P. Khincha, Sharon A. Savage, Vinod P. Balachandran, Jedd D. Wolchok, Matthew D. Hellmann, Taha Merghoub, Arnold J. Levine, Marta Łuksza, Benjamin D. Greenbaum

Publikováno v: Hoyos, D, Zappasodi, R, Schulze, I, Sethna, Z, de Andrade, K C, Bajorin, D F, Bandlamudi, C, Callahan, M K, Funt, S A, Hadrup, S R, Holm, J S, Rosenberg, J E, Shah, S P, Vázquez-García, I, Weigelt, B, Wu, M, Zamarin, D, Campitelli, L F, Osborne, E J, Klinger, M, Robins, H S, Khincha, P P, Savage, S A, Balachandran, V P, Wolchok, J D, Hellmann, M D, Merghoub, T, Levine, A J, Łuksza, M & Greenbaum, B D 2022, ' Fundamental immune–oncogenicity trade-offs define driver mutation fitness ', Nature, vol. 606, pp. 172-179 . https://doi.org/10.1038/s41586-022-04696-z

Missense driver mutations in cancer are concentrated in a few hotspots1. Various mechanisms have been proposed to explain this skew, including biased mutational processes2, phenotypic differences3–6 and immunoediting of neoantigens7,8; however, to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::788159a08120de98426bcab992e37aaa
https://doi.org/10.1038/s41586-022-04696-z

Supplementary Figure Legend from DNA Methyltransferase Inhibition Reverses Epigenetically Embedded Phenotypes in Lung Cancer Preferentially Affecting Polycomb Target Genes

Autor: Carsten Müller-Tidow, Nils H. Thoennissen, Martin Dugas, Wolfgang E. Berdel, Lara Tickenbrock, Rainer Wiewrodt, Seishi Ogawa, Isabell Schulze, Monika Stoll, Anika Witten, Dominik Jungen, Maria Rius, Hans-Ulrich Klein, Christian Rohde, Katja Hebestreit, Ann-Kristin Haase, Antje Hascher

PDF file - 52K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0625b9f1a97f01991ebbf39928f89c
https://doi.org/10.1158/1078-0432.22449639.v1

Supplementary Figures S1-6 from Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma

Autor: Carsten Müller-Tidow, Wolfgang E. Berdel, Stefan Burdach, Heribert Jürgens, Daniel Baumhoer, Claudia Rossig, Eva Wardelmann, Wolfgang Hartmann, Gabriele Köhler, Monika Stoll, Anika Witten, Regina Besoke, Isabell Schulze, Matthias Weckesser, Thorsten Buch, Eberhard Korsching, Kathrin Poos, Martin Dugas, Udo Kontny, Hans-Ulrich Klein, Benjamin Moser, Kristina von Heyking, Uta Dirksen, Eva Schmidt, Günther H.S. Richter, Konstantin Agelopoulos

Supplementary Figures S1-6. Supplementary Fig S1: Combined patient characteristics and subjected methods Supplementary Fig. S2 A: ROC curves were constructed by using the somatic scores from the sequenced genotypes. Supplementary Fig. S3: Circos plot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e66069dde343fc00689de337b82a9f
https://doi.org/10.1158/1078-0432.22459203