Cocrystals Enhance Biopharmaceutical and Antimicrobial Properties of Norfloxacin

Autor: Samantha Nascimento Gomes, Isabela Fanelli Barreto Biscaia, Diana Schon Lopes, Mariana Mengarda, Fábio Seigi Murakami, Paulo Renato Oliveira, Larissa Sakis Bernardi

Publikováno v: Pharmaceutics, Vol 15, Iss 9, p 2211 (2023)

A solvate cocrystal of the antimicrobial norfloxacin (NFX) was formed by using isonicotinamide (INA) as a coformer with the solvent evaporation technique. The cocrystal formation was confirmed by performing solid-state characterization techniques. We

Externí odkaz: https://doaj.org/article/96b0e551a4be4ce9a1b9055b49a0dc7c

Determination of Hydrochlorothiazide and Two Major Degradation Products by Stability Indicating High Performance Liquid Chromatography

Autor: Vítor Todeschini, Paulo R. Oliveira, Maximiliano da Silva Sangoi, Pedro Nicolau Severino Júnior, Cassiana Mendes, Isabela Fanelli Barreto Biscaia, Larissa S. Bernardi, Marcos Antonio Segatto Silva

Publikováno v: Current Pharmaceutical Analysis. 16:176-180

Background: Hydrochlorothiazide (HCTZ) is a thiazide diuretic which comprises two sulfonamide groups. The literature is not clear regarding the identification of the chromatographic peaks of its two major related substances: chlorothiazide and 4-amin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5196defb3a6a28e42b5f553d570010dc
https://doi.org/10.2174/1573412914666181017151551

Development of a First-Order Derivative UV Spectrophotometric Method for the Assay and Solubility Evaluation of Lamotrigine and Nicotinamide Cocrystals

Autor: Paulo R. Oliveira, Larissa S. Bernardi, Vítor Todeschini, Camila Tita Nogueira, Rafaela Zielinski Cavalheiro de Meira, Isabela Fanelli Barreto Biscaia

Publikováno v: Journal of the Brazilian Chemical Society, Volume: 31, Issue: 12, Pages: 2561-2568, Published: 14 DEC 2020
Journal of the Brazilian Chemical Society v.31 n.12 2020
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ

Pharmaceutical cocrystals are composed of a drug and a coformer and are currently gaining attention due to their possibility of improving drug solubility. Quantitative determination of cocrystals is usually carried out by liquid chromatography method

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd2a07dc18fdba2a8b87da71dbf8352f
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532020001202561&lng=en&tlng=en

Obtaining Cocrystals by Reaction Crystallization Method: Pharmaceutical Applications

Autor: Paulo R. Oliveira, Isabela Fanelli Barreto Biscaia, Larissa S. Bernardi, Samantha Nascimento Gomes

Publikováno v: Pharmaceutics, Vol 13, Iss 898, p 898 (2021)
Pharmaceutics

Cocrystals have gained attention in the pharmaceutical industry due to their ability to improve solubility, stability, in vitro dissolution rate, and bioavailability of poorly soluble drugs. Conceptually, cocrystals are multicomponent solids that con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b46f16498970ad071926eab2121277de
https://doi.org/10.3390/pharmaceutics13060898

Recent Findings in Ophthalmic Antiinfectives Described by a Researcher from Universidade Estadual do Centro-Oeste (Cocrystals Enhance Biopharmaceutical and Antimicrobial Properties of Norfloxacin).

Publikováno v: Drug Week; 9/15/2023, p2084-2084, 1p