Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Isabel X. Wang"'
Autor:
Isabel X. Wang, Leighton J. Core, Hojoong Kwak, Lauren Brady, Alan Bruzel, Lee McDaniel, Allison L. Richards, Ming Wu, Christopher Grunseich, John T. Lis, Vivian G. Cheung
Publikováno v:
Cell Reports, Vol 6, Iss 5, Pp 906-915 (2014)
RNA sequences are expected to be identical to their corresponding DNA sequences. Here, we found all 12 types of RNA-DNA sequence differences (RDDs) in nascent RNA. Our results show that RDDs begin to occur in RNA chains ∼55 nt from the RNA polymera
Externí odkaz:
https://doaj.org/article/5f2aebfb28ce422f95afdc0f229f309e
Publikováno v:
Cell Reports, Vol 5, Iss 3, Pp 849-860 (2013)
Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine, which is then recognized as guanosine. To study the role of ADAR proteins in RNA editing and gene regulation, we sequenced and compared the DNA and RNA of human B cells. Then, w
Externí odkaz:
https://doaj.org/article/82963d84456d4452ab5ff126a49febb9
Autor:
Christopher Grunseich, Joshua T. Burdick, Isabel X. Wang, Vivian G. Cheung, Markus Hafner, Jennifer E. Fox, Zhengwei Zhu, Niema Ravazian
Publikováno v:
Genome Research. 28:1405-1414
RNA/DNA hybrids form when RNA hybridizes with its template DNA generating a three-stranded structure known as the R-loop. Knowledge of how they form and resolve, as well as their functional roles, is limited. Here, by pull-down assays followed by mas
Publikováno v:
Genome Research. 26:799-811
Complex regulation of gene expression in mammals has evolved from simpler eukaryotic systems, yet the mechanistic features of this evolution remain elusive. Here, we compared the transcriptional landscapes of the distantly related budding and fission
Autor:
Youree G. Chung, Zhengwei Zhu, Isabel X. Wang, Girish Ramrattan, Vivian G. Cheung, Hojoong Kwak, Christopher Grunseich
Alterations of RNA sequences and structures, such as those from editing and alternative splicing, result in two or more RNA transcripts from a DNA template. It was thought that in yeast, RNA editing only occurs in tRNAs. Here, we found that Saccharom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0159c54ad2bf79d99723cd894b95d564
https://europepmc.org/articles/PMC5088596/
https://europepmc.org/articles/PMC5088596/
Publikováno v:
Cell Reports, Vol 5, Iss 3, Pp 849-860 (2013)
Cell reports
Cell reports
SUMMARY Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine, which is then recognized as guanosine. To study the role of ADAR proteins in RNA editing and gene regulation, we sequenced and compared the DNA and RNA of human B cells.
Autor:
Jonathan M. Toung, Alan Bruzel, Isabel X. Wang, Allison L. Richards, Yun Li, Vivian G. Cheung, Mingyao Li
Publikováno v:
Science. 333:53-58
The transmission of information from DNA to RNA is a critical process. We compared RNA sequences from human B cells of 27 individuals to the corresponding DNA sequences from the same individuals and uncovered more than 10,000 exonic sites where the R
Autor:
Tyler Lanman, Alan Bruzel, Nancy A. Edwards, Barbara J. Crain, Tanya J. Lehky, Alice B. Schindler, Ke-lian Chen, Kenneth H. Fischbeck, Jason A. Watts, Grzegorz Piszczek, Robert D. Guber, Zhengwei Zhu, Christopher Grunseich, Joshua T. Burdick, Abhik Ray-Chaudhury, Jianhua Yao, Isabel X. Wang, Vivian G. Cheung
Publikováno v:
Molecular Cell. 69:426-437.e7
R-loops are three-stranded nucleic acid structures found abundantly and yet often viewed as by-products of transcription. Studying cells from patients with a motor neuron disease (amyotrophic lateral sclerosis 4 [ALS4]) caused by a mutation in senata
Autor:
Rolf Sternglanz, Isabel X. Wang, Vinaya Sampath, Fred van Leeuwen, Evelyn Prugar, Peihua Yuan
Publikováno v:
Molecular and Cellular Biology. 29:2532-2545
Sir3, a component of the transcriptional silencing complex in the yeast Saccharomyces cerevisiae, has an N-terminal BAH domain that is crucial for the protein's silencing function. Previous work has shown that the N-terminal alanine residue of Sir3 (
Publikováno v:
Molecular Systems Biology
Individual differences in sensitivity to insulin contribute to disease susceptibility including diabetes and metabolic syndrome. Cellular responses to insulin are well studied. However, which steps in these response pathways differ across individuals