Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Isabel Weigand"'
Autor:
Qian Wang, Na Sun, Raphael Meixner, Ronan Le Gleut, Thomas Kunzke, Annette Feuchtinger, Jun Wang, Jian Shen, Stefan Kircher, Ulrich Dischinger, Isabel Weigand, Felix Beuschlein, Martin Fassnacht, Matthias Kroiss, Axel Walch
Publikováno v:
JCI Insight, Vol 8, Iss 16 (2023)
Spatially resolved metabolomics enables the investigation of tumoral metabolites in situ. Inter- and intratumor heterogeneity are key factors associated with patient outcomes. Adrenocortical carcinoma (ACC) is an exceedingly rare tumor associated wit
Externí odkaz:
https://doaj.org/article/99905d4dc627486f9868383e84a8d070
Autor:
Martin Fassnacht, Matthias Kroiss, Laura-Sophie Landwehr, Barbara Altieri, Jochen Schreiner, Iuliu Sbiera, Isabel Weigand, Silviu Sbiera
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Background Adrenocortical carcinoma (ACC) is a rare endocrine malignancy. Tumor-related glucocorticoid excess is present in ~60% of patients and associated with particularly poor prognosis. Results of first clinical trials using immune checkpoint inh
Externí odkaz:
https://doaj.org/article/5a21351a1ab74a0190eb42983dacae69
Autor:
Raimunde Liang, Isabel Weigand, Juliane Lippert, Stefan Kircher, Barbara Altieri, Sonja Steinhauer, Constanze Hantel, Simone Rost, Andreas Rosenwald, Matthias Kroiss, Martin Fassnacht, Silviu Sbiera, Cristina L. Ronchi
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Adrenocortical carcinomas (ACC) are aggressive tumors with a heterogeneous prognosis and limited therapeutic options for advanced stages. This study aims to identify novel drug targets for a personalized treatment in ACC. RNA was isolated from 40 for
Externí odkaz:
https://doaj.org/article/cb032d05d2054da089a268d18cce42ce
Autor:
Isabel Weigand, Cristina L. Ronchi, Marthe Rizk-Rabin, Guido Di Dalmazi, Vanessa Wild, Kerstin Bathon, Beatrice Rubin, Davide Calebiro, Felix Beuschlein, Jérôme Bertherat, Martin Fassnacht, Silviu Sbiera
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Somatic mutations in protein kinase A catalytic α subunit (PRKACA) were found to be causative for 30–40% of cortisol-producing adenomas (CPA) of the adrenal gland, rendering PKA signalling constitutively active. In its resting state, PKA
Externí odkaz:
https://doaj.org/article/a7dfc728130647c9871d28bac6b0b73e
Autor:
Silviu Sbiera, Marianna A Tryfonidou, Isabel Weigand, Guy C M Grinwis, Bart Broeckx, Sabine Herterich, Bruno Allolio, Timo Deutschbein, Martin Fassnacht, Björn P Meij
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0169009 (2016)
Cushing's disease (CD), also known as pituitary-dependent hyperadrenocorticism, is caused by adrenocorticotropic hormone (ACTH)-secreting pituitary tumours. Affected humans and dogs have similar clinical manifestations, however, the incidence of the
Externí odkaz:
https://doaj.org/article/68586dba240044599062f2469bddc052
Autor:
Laura-Sophie Landwehr, Silke Appenzeller, Laura Olsner, Isabel Weigand, Silviu Sbiera, Martin Fassnacht, Matthias Kroiss
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a9b14fd195812bfaf3562b7571a60a4
https://doi.org/10.1530/endoabs.90.p113
https://doi.org/10.1530/endoabs.90.p113
Autor:
Carmen Ruggiero, Mariangela Tamburello, Elisa Rossini, Silvia Zini, Nelly Durand, Giulia Cantini, Francesca Cioppi, Constanze Hantel, Katja Kiseljak‐Vassiliades, Margaret E. Wierman, Laura‐Sophie Landwehr, Isabel Weigand, Max Kurlbaum, Daniela Zizioli, Andrei Turtoi, Shengyu Yang, Alfredo Berruti, Michaela Luconi, Sandra Sigala, Enzo Lalli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d85c275eecf785a48c9589bc5a3330
https://hdl.handle.net/11379/575085
https://hdl.handle.net/11379/575085
Autor:
Thiago C. Genaro-Mattos, Alex Inague, Marcus Conrad, Helene Nehring, Svenja Lorenz, Viktoria Kunz, Werner Schmitz, Kurt Bommert, Ann Wehmann, Matthias Kroiss, Palina Nepachalovich, Peter Imming, Lohans Puentes, Derek A. Pratt, Maria Fedorova, Ana J. García-Sáez, Isabel Weigand, Sayuri Miyamoto, José Pedro Friedmann Angeli, Georg W. Bornkamm, Omkar Zilka, Svenja Meierjohann, Aline Horling, Karoly Mirnics, Sebastian Doll, Judith Klein-Seetharaman, Thamara Nishida Xavier da Silva, Florencio Porto Freitas, Zhiyi Chen, Ralf C. Bargou, Lokender Kumar
Ferroptosis is a form of cell death that has received considerable attention not only as a means to eradicate defined tumour entities but also because it provides unforeseen insights into the metabolic adaptation exploited by tumours to counteract ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::703978e824ead0a90c88e0a1c2f424d6
https://doi.org/10.21203/rs.3.rs-943221/v1
https://doi.org/10.21203/rs.3.rs-943221/v1
Publikováno v:
Molecular and Cellular Endocrinology. 480:36-41
90 kDa heat shock proteins (Hsp90) act as protein chaperones and play a role in modulating endoplasmic reticulum (ER) stress. Hsp90 inhibitors are under clinical investigation as cancer treatment. Mitotane therapy of adrenocortical carcinoma (ACC) ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40fde871cad78f8b30ddebe5bcf6ec37
https://doi.org/10.1016/j.mce.2018.10.009
https://doi.org/10.1016/j.mce.2018.10.009
Autor:
Silke Appenzeller, Andrea Gehrig, Barbara Altieri, Cristina L Ronchi, Sonja Steinhauer, Simone Rost, Silviu Sbiera, Juliane Lippert, Matthias Kroiss, Andreas Rosenwald, Martin Fassnacht, Clemens R. Mueller, Isabel Weigand, Raimunde Liang, Stefan Kircher, Renzo J. M. Riemens, Indrajit Nanda
Publikováno v:
Journal of Clinical Endocrinology & Metabolism, 103(12), 4511-4523. Oxford University Press
Context Adrenocortical carcinoma (ACC) has a heterogeneous prognosis, and current medical therapies have limited efficacy in its advanced stages. Genome-wide multiomics studies identified molecular patterns associated with clinical outcome. Objective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee3a6cad539dbbe4ce81593df569737a
https://doi.org/10.1210/jc.2018-01348
https://doi.org/10.1210/jc.2018-01348