Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Isabel Sastre"'
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Background Mounting data suggests that herpes simplex virus type 1 (HSV-1) is involved in the pathogenesis of AD, possibly instigating amyloid-beta (Aβ) accumulation decades before the onset of clinical symptoms. However, human in vivo evid
Externí odkaz:
https://doaj.org/article/3981710a3aa949b989ce051f621a8ca1
Autor:
Blanca Salgado, Beatriz Izquierdo, Alba Zapata, Isabel Sastre, Henrike Kristen, Julia Terreros, Víctor Mejías, María J. Bullido, Jesús Aldudo
Publikováno v:
Biomolecules, Vol 14, Iss 5, p 603 (2024)
Cholesterol, a crucial component of cell membranes, influences various biological processes, including membrane trafficking, signal transduction, and host-pathogen interactions. Disruptions in cholesterol homeostasis have been linked to congenital an
Externí odkaz:
https://doaj.org/article/6719a343f0934541b62d9d79db735afe
Autor:
Zoe Mariño, Marina Berenguer, Luis Peña-Quintana, Antonio Olveira, Anna Miralpeix, Isabel Sastre, Ana Reyes-Domínguez, Pilar Castillo, Clàudia García-Solà, Ariadna Bono, Miriam Romero, Francisco Javier Pérez-Sádaba, Susana Aceituno, Anna Anguera
Publikováno v:
Journal of Clinical Medicine, Vol 12, Iss 14, p 4823 (2023)
Wilson disease (WD) is a rare copper metabolism disorder caused by mutations in the ATP7B gene. It usually affects young individuals and can produce hepatic and/or neurological involvement, potentially affecting health-related quality of life (HRQoL)
Externí odkaz:
https://doaj.org/article/8da5f6458c974f55b85068b96b56aee3
Publikováno v:
Microorganisms, Vol 11, Iss 5, p 1205 (2023)
An increasing body of evidence strongly suggests that infections or reactivations of herpes simplex virus type 1 (HSV-1) may be closely linked to Alzheimer’s disease (AD). Promising results have been obtained using cell and animal models of HSV-1 i
Externí odkaz:
https://doaj.org/article/d917fe189147497fbd9c322406424355
Autor:
Dolores Martínez-Rubio, Isabel Hinarejos, Paula Sancho, Nerea Gorría-Redondo, Raquel Bernadó-Fonz, Cristina Tello, Clara Marco-Marín, Itxaso Martí-Carrera, María Jesús Martínez-González, Ainhoa García-Ribes, Raquel Baviera-Muñoz, Isabel Sastre-Bataller, Irene Martínez-Torres, Anna Duat-Rodríguez, Patrícia Janeiro, Esther Moreno, Leticia Pías-Peleteiro, Mar O’Callaghan Gordo, Ángeles Ruiz-Gómez, Esteban Muñoz, Maria Josep Martí, Ana Sánchez-Monteagudo, Candela Fuster, Amparo Andrés-Bordería, Roser Maria Pons, Silvia Jesús-Maestre, Pablo Mir, Vincenzo Lupo, Belén Pérez-Dueñas, Alejandra Darling, Sergio Aguilera-Albesa, Carmen Espinós
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11847 (2022)
Our clinical series comprises 124 patients with movement disorders (MDs) and/or ataxia with cerebellar atrophy (CA), many of them showing signs of neurodegeneration with brain iron accumulation (NBIA). Ten NBIA genes are accepted, although isolated c
Externí odkaz:
https://doaj.org/article/65e1319d27ad461db2e041f1cb14beef
Autor:
Pilar López-Nieva, Pablo Fernández-Navarro, Concepción Vaquero-Lorenzo, María Villa-Morales, Osvaldo Graña-Castro, María Ángeles Cobos-Fernández, José Luis López-Lorenzo, Pilar Llamas, Laura González-Sanchez, Isabel Sastre, Marina Pollan, Marcos Malumbres, Javier Santos, José Fernández-Piqueras
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-12 (2018)
Abstract Background Precursor T-cell lymphoblastic lymphomas (T-LBL) are rare aggressive hematological malignancies that mainly develop in children. As in other cancers, the loss of cell cycle control plays a prominent role in the pathogenesis in the
Externí odkaz:
https://doaj.org/article/8c05930c4cca48cc98e127c09078321c
Autor:
Isabel Sastre Gervás, Juana María Cruz del Río, Natalia Cal Purriños, Rosendo Bugarín González
Publikováno v:
Atención Primaria, Vol 52, Iss 6, Pp 440-441 (2020)
Externí odkaz:
https://doaj.org/article/df9817150fef49e883fb3624290bad85
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e75842 (2013)
Mounting evidence suggests that Herpes simplex virus type 1 (HSV-1) is involved in the pathogenesis of Alzheimer's disease (AD). Previous work from our laboratory has shown HSV-1 infection to induce the most important pathological hallmarks of AD bra
Externí odkaz:
https://doaj.org/article/b7110f6841c04a15b773ddf066aeff29
Autor:
Olga Calero, María J Bullido, Jordi Clarimón, Ana Frank-García, Pablo Martínez-Martín, Alberto Lleó, María Jesús Rey, Isabel Sastre, Alberto Rábano, Jesús de Pedro-Cuesta, Isidro Ferrer, Miguel Calero
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43926 (2012)
The β site APP cleaving enzyme 1 (BACE1) is the rate-limiting β-secretase enzyme in the amyloidogenic processing of APP and Aβ formation, and therefore it has a prominent role in Alzheimer's disease (AD) pathology. Recent evidence suggests that th
Externí odkaz:
https://doaj.org/article/76c035cb655b40cfa75b6d58e94ed55d
Autor:
Antonio Lahera, Pilar López‐Nieva, Hernán Alarcón, José L. Marín‐Rubio, María Á. Cobos‐Fernández, Pablo Fernández‐Navarro, Agustín F. Fernández, Laura Vela‐Martín, Isabel Sastre, Sara Ruiz‐García, Pilar Llamas, José L. López‐Lorenzo, Javier Cornago, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales
Publikováno v:
Scopus
Despite the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway being frequently altered in T-ALL/LBL, no specific therapy has been approved for T-ALL/LBL patients with constitutive signalling by JAK/STAT, so there is a