Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Isabel Roditi"'
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Developmental regulation of mitochondrial uridine insertion/deletion editing in Trypanosoma brucei is necessary to modulate parasite metabolism as it shifts from dependence on glycolysis for ATP production in the mammalian bloodstream form (
Externí odkaz:
https://doaj.org/article/01f5329e6f9e41f6add10b90b179be75
Autor:
Sebastian Shaw, Sebastian Knüsel, Daniel Abbühl, Arunasalam Naguleswaran, Ruth Etzensperger, Mattias Benninger, Isabel Roditi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
African trypanosomes collectively move in a process called social motility. Here, the authors show that procyclic forms acidify their environment as a consequence of glucose metabolism, generating pH gradients by diffusion that are sensed via cyclic
Externí odkaz:
https://doaj.org/article/1360a9650cc043f4bd6369e9b115cd99
Publikováno v:
BMC Research Notes, Vol 13, Iss 1, Pp 1-6 (2020)
Abstract Objective Generation of knockouts and in situ tagging of genes in Trypanosoma brucei has been greatly facilitated by using CRISPR/Cas9 as a genome editing tool. To date, this has entailed using a limited number of cell lines that are stably
Externí odkaz:
https://doaj.org/article/02af29af96c14bc4bf5589032fda72c3
Autor:
Fabian Hulpia, Dorien Mabille, Gustavo D. Campagnaro, Gabriela Schumann, Louis Maes, Isabel Roditi, Anders Hofer, Harry P. de Koning, Guy Caljon, Serge Van Calenbergh
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Trypanosoma brucei relies on uptake and conversion of purines from the host, which constitutes a potential drug target. Here, Hulpia et al. combine structural elements from known trypanocidal nucleoside analogues and develop a potent trypanocide with
Externí odkaz:
https://doaj.org/article/ac12d894b82c4ecab2670dd0dcf7314e
Autor:
Arunasalam Naguleswaran, Paula Fernandes, Shubha Bevkal, Ruth Rehmann, Pamela Nicholson, Isabel Roditi
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 9, p e0009504 (2021)
Trypanosoma brucei ssp., unicellular parasites causing human and animal trypanosomiasis, are transmitted between mammals by tsetse flies. Periodic changes in variant surface glycoproteins (VSG), which form the parasite coat in the mammal, allow them
Externí odkaz:
https://doaj.org/article/10ad374d0e6749e0a2ce73fcf1e8ef83
Autor:
Sebastian Shaw, Stephanie F. DeMarco, Ruth Rehmann, Tanja Wenzler, Francesca Florini, Isabel Roditi, Kent L. Hill
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Trypanosoma brucei probably relies on chemotactic signals for movement through tsetse fly tissues, but the molecular basis is unknown. Here, the authors show that flagellar cAMP signaling is required for traversal of the peritrophic matrix and that,
Externí odkaz:
https://doaj.org/article/30f4254f1f9248b0a285b1c1494715d5
Autor:
Shubha Bevkal, Arunasalam Naguleswaran, Ruth Rehmann, Marcel Kaiser, Manfred Heller, Isabel Roditi
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009239 (2021)
The transition between hosts is a challenge for digenetic parasites as it is unpredictable. For Trypanosoma brucei subspecies, which are disseminated by tsetse flies, adaptation to the new host requires differentiation of stumpy forms picked up from
Externí odkaz:
https://doaj.org/article/ee0ae78a0c3649a9bd2e2de1623db7ac
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-11 (2018)
Abstract Background Trypanosoma brucei brucei, the parasite causing Nagana in domestic animals, is closely related to the parasites causing sleeping sickness, but does not infect humans. In addition to its importance as a pathogen, the relative ease
Externí odkaz:
https://doaj.org/article/21dca15a872b43a3bffc2836a067f4f5
Autor:
Simon Imhof, Cristina Fragoso, Andrew Hemphill, Conrad von Schubert, Dong Li, Wesley Legant, Eric Betzig, Isabel Roditi
Publikováno v:
F1000Research, Vol 5 (2016)
Diverse structures facilitate direct exchange of proteins between cells, including plasmadesmata in plants and tunnelling nanotubes in bacteria and higher eukaryotes. Here we describe a new mechanism of protein transfer, flagellar membrane fusion, in
Externí odkaz:
https://doaj.org/article/0945cf0ee27c451c9788cebd64cdb028
Autor:
Arunasalam Naguleswaran, Kapila Gunasekera, Bernd Schimanski, Manfred Heller, Andrew Hemphill, Torsten Ochsenreiter, Isabel Roditi
Publikováno v:
mBio, Vol 6, Iss 2 (2015)
ABSTRACT TbRRM1 of Trypanosoma brucei is a nucleoprotein that was previously identified in a search for splicing factors in T. brucei. We show that TbRRM1 associates with mRNAs and with the auxiliary splicing factor polypyrimidine tract-binding prote
Externí odkaz:
https://doaj.org/article/da0b481d64e14f18bf26068751de0ed7