Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Isabel Risch"'
Autor:
Xinran Dong, Liang Ding, Andrew Thrasher, Xinge Wang, Jingjing Liu, Qingfei Pan, Jordan Rash, Yogesh Dhungana, Xu Yang, Isabel Risch, Yuxin Li, Lei Yan, Michael Rusch, Clay McLeod, Koon-Kiu Yan, Junmin Peng, Hongbo Chi, Jinghui Zhang, Jiyang Yu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Many signaling and other genes known as “hidden” drivers may not be genetically or epigenetically altered or differentially expressed at the mRNA or protein levels, but, rather, drive a phenotype such as tumorigenesis via post-translatio
Externí odkaz:
https://doaj.org/article/14c0f151bd884b528e374cdf295c69fb
Autor:
Jiyang Yu, Liang Ding, Hao Shi, Chenxi Qian, Chad Burdyshaw, Joao Veloso, Alireza Khatamian, Qingfei Pan, Yogesh Dhungana, Zhen Xie, Isabel Risch, Xu Yang, Xin Huang, Lei Yan, Michael Rusch, Michael Brewer, Koon-Kiu Yan, Hongbo Chi
Publikováno v:
bioRxiv
The sparse nature of single-cell omics data makes it challenging to dissect the wiring and rewiring of the transcriptional and signaling drivers that regulate cellular states. Many of the drivers, referred to as “hidden drivers”, are difficult to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ab6a33393166f6f7c35d2ad5e60dc4
https://doi.org/10.1101/2023.01.26.523391
https://doi.org/10.1101/2023.01.26.523391
Autor:
Lingyun Long, Jiyang Yu, Peter Vogel, Nicole M. Chapman, Hongling Huang, Junmin Peng, Boer Xie, Cliff Guy, Anil Kc, Seon Ah Lim, Isabel Risch, Yanyan Wang, Mingming Niu, Yuxin Li, Hongbo Chi, Jon P. Connelly, Jana L. Raynor, Wei Su, Yong-Dong Wang, Yogesh Dhungana, Hong Wang, Hao Shi, Guotong Fu, Peipei Zhou, Jordy Saravia, Shondra M. Pruett-Miller, Jun Wei
Publikováno v:
Nature
Nutrients are emerging regulators of adaptive immunity1. Selective nutrients interplay with immunological signals to activate mechanistic target of rapamycin complex 1 (mTORC1), a key driver of cell metabolism2–4, but how these environmental signal
Autor:
Jiyang Yu, Xinran Dong, Liang Ding, Andrew Thrasher, Xinge Wang, Jingjing Liu, Qingfei Pan, Jordan Rash, Yogesh Dhungana, Xu Yang, Isabel Risch, Yuxin Li, Junmin Peng, Michael Rusch, Clay McLeod, Hongbo Chi, Jinghui Zhang
We present a comprehensive and versatile toolkit, NetBID2, for integrating multi-omics data and exposing hidden drivers that are not genetically altered or differentially expressed at the RNA/protein level by reverse-engineering context-specific inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99fd529da372edbedcc843d7e9d536ae
https://doi.org/10.21203/rs.3.rs-2176707/v1
https://doi.org/10.21203/rs.3.rs-2176707/v1
Autor:
Daniel Bastardo Blanco, Nicole M. Chapman, Jana L. Raynor, Chengxian Xu, Wei Su, Anil KC, Wei Li, Seon Ah Lim, Stefan Schattgen, Hao Shi, Isabel Risch, Yu Sun, Yogesh Dhungana, Yunjung Kim, Jun Wei, Sherri Rankin, Geoffrey Neale, Paul G. Thomas, Kai Yang, Hongbo Chi
Publikováno v:
Nature cell biology. 24(11)
Phosphatase and tensin homologue (PTEN) is frequently mutated in human cancer, but its roles in lymphopoiesis and tissue homeostasis remain poorly defined. Here we show that PTEN orchestrates a two-step developmental process linking antigen receptor