Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Isabel R. Schlaepfer"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/eeaa7dd8c8484341aafd89c216c14b74
Publikováno v:
Polymers, Vol 13, Iss 3, p 377 (2021)
Light-sensitive polymeric micelles have recently emerged as promising drug delivery systems for spatiotemporally controlled release of payload at target sites. Here, we developed diazonaphthoquinone (DNQ)-conjugated micellar nanoparticles that showed
Externí odkaz:
https://doaj.org/article/f45a289a1e5e49e48fe041718e764c61
Autor:
Amanda Guth, Emily Monk, Rajesh Agarwal, Bryan C. Bergman, Karin A. Zemski-Berry, Angela Minic, Kimberly Jordan, Isabel R. Schlaepfer
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 24, p 9660 (2020)
Lipid catabolism represents an Achilles heel in prostate cancer (PCa) that can be exploited for therapy. CPT1A regulates the entry of fatty acids into the mitochondria for beta-oxidation and its inhibition has been shown to decrease PCa growth. In th
Externí odkaz:
https://doaj.org/article/6baa5ad73eed4e3dbc8ff312e5c0b2b6
Autor:
Molishree Joshi, Gergana E. Stoykova, Maren Salzmann-Sullivan, Monika Dzieciatkowska, Lauren N. Liebman, Gagan Deep, Isabel R. Schlaepfer
Publikováno v:
Cells, Vol 8, Iss 10, p 1115 (2019)
Prostate cancer (PCa) is the most common cancer in men, and the global burden of the disease is rising. The majority of PCa deaths are due to metastasis that are highly resistant to current hormonal treatments; this state is called castration-resista
Externí odkaz:
https://doaj.org/article/cd0d7f927ce544b38cf578d9a30aa450
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 11, p 2626 (2019)
Prostate cancer (PCa) is the most common cancer in men, and more than 10% of men will be diagnosed with PCa during their lifetime. Patients that are not cured with surgery or radiation are largely treated with endocrine therapies that target androgen
Externí odkaz:
https://doaj.org/article/395467c0aee14d42a6f5b6beb0910d39
Autor:
Isabel R. Schlaepfer, Leslie K. Pulawa, Luis D.M. C-B. Ferreira, David E. James, Warren H. Capell, Robert H. Eckel
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 6, Pp 1174-1181 (2003)
Fatty acids inhibit insulin-mediated glucose metabolism in skeletal muscle, an effect largely attributed to defects in insulin-mediated glucose transport. Insulin-resistant mice transgenic for the overexpression of lipoprotein lipase (LPL) in skeleta
Externí odkaz:
https://doaj.org/article/c020cd405a434ea7ab6b44d161cead68
Autor:
Gagan Deep, Isabel R. Schlaepfer
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 7, p 1061 (2016)
Prostate cancer (PCa) is the leading malignancy among men in United States. Recent studies have focused on the identification of novel metabolic characteristics of PCa, aimed at devising better preventive and therapeutic approaches. PCa cells have re
Externí odkaz:
https://doaj.org/article/3f08b2a25a5d4c49a02cd2defa36a97b
Autor:
Scott D. Cramer, Robert H. Eckel, L. Michael Glodé, S. Joseph Sirintrapun, Adela Cimic, Lina Romero, Colton T. Pac, Miguel A. Gijón, Lindsey Ulkus Rodrigues, Leah Rider, Isabel R. Schlaepfer
Supplementary figure 4: Palmitate supplementation decreases the spliced/unspliced XBP-1 ratio: LNCaP cells were treated over 48 hours with etomoxir and and with or without 100uM palmitate conjugated to albumin. Supplements Figure 4A.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::190a0d30bdab1501d7e05011054382c8
https://doi.org/10.1158/1535-7163.22502767
https://doi.org/10.1158/1535-7163.22502767
Autor:
Scott D. Cramer, Robert H. Eckel, L. Michael Glodé, S. Joseph Sirintrapun, Adela Cimic, Lina Romero, Colton T. Pac, Miguel A. Gijón, Lindsey Ulkus Rodrigues, Leah Rider, Isabel R. Schlaepfer
Supplementary figure 2: Additional human Prostate-derived patient-matched cell lines exposed to metabolic inhibitors: MTS proliferation assay of patient-matched prostate-derived benign (A) and cancer (B) cells exposed to Etomoxir and/or Orlistat for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba09614a14b61f5d579620761b1ded9
https://doi.org/10.1158/1535-7163.22502773
https://doi.org/10.1158/1535-7163.22502773
Autor:
Scott D. Cramer, Robert H. Eckel, L. Michael Glodé, S. Joseph Sirintrapun, Adela Cimic, Lina Romero, Colton T. Pac, Miguel A. Gijón, Lindsey Ulkus Rodrigues, Leah Rider, Isabel R. Schlaepfer
Supplementary figure 3: Cleaved Caspase 3 expression in LNCaP and BPH-1 cells: Cells were treated with etomoxir over a 16 hour period and the activation of caspase 3 was examined by western blot in the cell lysates. Supplements Figure 3.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::125de67cc3c350302a1434d7de297071
https://doi.org/10.1158/1535-7163.22502770
https://doi.org/10.1158/1535-7163.22502770