Výsledky vyhledávání - "Isabel Pagani"

Akademický článek

Heparin Precursors with Reduced Anticoagulant Properties Retain Antiviral and Protective Effects That Potentiate the Efficacy of Sofosbuvir against Zika Virus Infection in Human Neural Progenitor Cells

Autor: Isabel Pagani, Linda Ottoboni, Paola Panina-Bordignon, Gianvito Martino, Guido Poli, Sarah Taylor, Jeremy E. Turnbull, Edwin Yates, Elisa Vicenzi

Publikováno v: Pharmaceuticals, Vol 16, Iss 10, p 1385 (2023)

Zika virus (ZIKV) infection during pregnancy can result in severe birth defects, such as microcephaly, as well as a range of other related health complications. Heparin, a clinical-grade anticoagulant, is shown to protect neural progenitor cells from

Externí odkaz: https://doaj.org/article/98adebd698484caea4922e5c31983183

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Akademický článek

The Hyperlipidaemic Drug Fenofibrate Significantly Reduces Infection by SARS-CoV-2 in Cell Culture Models

Autor: Scott P. Davies, Courtney J. Mycroft-West, Isabel Pagani, Harriet J. Hill, Yen-Hsi Chen, Richard Karlsson, Ieva Bagdonaite, Scott E. Guimond, Zania Stamataki, Marcelo Andrade De Lima, Jeremy E. Turnbull, Zhang Yang, Elisa Vicenzi, Mark A. Skidmore, Farhat L. Khanim, Alan Richardson

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has caused a significant number of fatalities and worldwide disruption. To identify drugs to repurpose to treat SARS-CoV-2 infections, we established a screen to measure the di

Externí odkaz: https://doaj.org/article/1ca1ccf941184afc912bd210a2089c17

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Akademický článek

TRIM22. A Multitasking Antiviral Factor

Autor: Isabel Pagani, Guido Poli, Elisa Vicenzi

Publikováno v: Cells, Vol 10, Iss 8, p 1864 (2021)

Viral invasion of target cells triggers an immediate intracellular host defense system aimed at preventing further propagation of the virus. Viral genomes or early products of viral replication are sensed by a number of pattern recognition receptors,

Externí odkaz: https://doaj.org/article/c512ad8c9e2d4bab9aecff6f32224f47

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Akademický článek

Mutations Conferring Increased Sensitivity to Tripartite Motif 22 Restriction Accumulated Progressively in the Nucleoprotein of Seasonal Influenza A (H1N1) Viruses between 1918 and 2009

Autor: Isabel Pagani, Andrea Di Pietro, Alexandra Oteiza, Michela Ghitti, Nadir Mechti, Nadia Naffakh, Elisa Vicenzi

Publikováno v: mSphere, Vol 3, Iss 2 (2018)

ABSTRACT Influenza A viruses (IAVs) can cause zoonotic infections with pandemic potential when most of the human population is immunologically naive. After a pandemic, IAVs evolve to become seasonal in the human host by acquiring adaptive mutations.

Externí odkaz: https://doaj.org/article/859e81a9b890458684b2c5c2d67ccc01

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Pentosan Polysulfate Inhibits Attachment and Infection by SARS-CoV-2 In Vitro: Insights into Structural Requirements for Binding

Autor: Sabrina, Bertini, Anna, Alekseeva, Stefano, Elli, Isabel, Pagani, Serena, Zanzoni, Giorgio, Eisele, Ravi, Krishnan, Klaus P, Maag, Christian, Reiter, Dominik, Lenhart, Rudolf, Gruber, Edwin A, Yates, Elisa, Vicenzi, Annamaria, Naggi, Antonella, Bisio, Marco, Guerrini

Publikováno v: Thrombosis and Haemostasis. 122:984-997

Two years since the outbreak of the novel coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pandemic, there remain few clinically effective drugs to complement vaccines. One is the anticoagulant, heparin, which in 2004 was foun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0486ea2eea8a702d9880fffe325b52a8
https://doi.org/10.1055/a-1807-0168

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Origin and evolution of SARS-CoV-2

Autor: Isabel Pagani, Silvia Ghezzi, Simone Alberti, Guido Poli, Elisa Vicenzi

Publikováno v: The European Physical Journal Plus. 138

SARS-CoV-2 is a novel coronavirus that emerged in China at the end of 2019 causing the severe disease known as coronavirus disease 2019 (COVID-19). SARS-CoV-2, as to the previously highly pathogenic human coronaviruses named SARS-CoV, the etiological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b48707f73c3c172e455cb71b9f2d283
https://doi.org/10.1140/epjp/s13360-023-03719-6

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Heparin Protects Human Neural Progenitor Cells from Zika Virus-Induced Cell Death While Preserving Their Differentiation into Mature Neuroglial Cells

Autor: Isabel Pagani, Linda Ottoboni, Paola Podini, Silvia Ghezzi, Elena Brambilla, Svetlana Bezukladova, Davide Corti, Marco Emilio Bianchi, Maria Rosaria Capobianchi, Guido Poli, Paola Panina-Bordignon, Edwin A. Yates, Gianvito Martino, Elisa Vicenzi

Publikováno v: Journal of virology. 96(19)

ZIKV is a neurotropic virus that invades neural progenitor cells (NPCs), causing inhibition of their proliferation and maturation into neurons and glial cells. We have shown previously that heparin, an anticoagulant also used widely during pregnancy,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa89322444f6a4d4151204253b978496
https://pubmed.ncbi.nlm.nih.gov/36121298

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