Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Isabel Marzo"'
Autor:
Manuel Beltrán‐Visiedo, Nelia Jiménez‐Alduán, Rosana Díez, Marta Cuenca, Andrea Benedi, Alfonso Serrano‐Del Valle, Gemma Azaceta, Luis Palomera, Victor Peperzak, Alberto Anel, Javier Naval, Isabel Marzo
Publikováno v:
Molecular Oncology, Vol 17, Iss 12, Pp 2507-2525 (2023)
A better understanding of multiple myeloma (MM) biology has led to the development of novel therapies. However, MM is still an incurable disease and new pharmacological strategies are needed. Dinaciclib, a multiple cyclin‐dependent kinase (CDK) inh
Externí odkaz:
https://doaj.org/article/597889ddd17c42ce92b6008ca8428ba5
Autor:
Nerea Allende-Vega, Joaquin Marco Brualla, Paolo Falvo, Catherine Alexia, Michael Constantinides, Alexis Fayd’herbe de Maudave, Lois Coenon, Delphine Gitenay, Giulia Mitola, Paul Massa, Stefania Orecchioni, Francesco Bertolini, Isabel Marzo, Alberto Anel, Martin Villalba
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Solid tumor cells have an altered metabolism that can protect them from cytotoxic lymphocytes. The anti-diabetic drug metformin modifies tumor cell metabolism and several clinical trials are testing its effectiveness for the treatment of sol
Externí odkaz:
https://doaj.org/article/80ab263158524947a4f42174b3b1b555
Autor:
Sandra Ardevines, Fernando Auria-Luna, Eduardo Romanos, Vanesa Fernández-Moreira, Andrea Benedi, M. Concepción Gimeno, Isabel Marzo, Eugenia Marqués-López, Raquel P. Herrera
Publikováno v:
Arabian Journal of Chemistry, Vol 16, Iss 2, Pp 104514- (2023)
1,4-Dihydropyridine is a privileged scaffold present in many bioactive molecules, from coenzymes to commercially available drugs. Among other interesting properties, it has been found good anticancer activity in some of these 1,4-DHPs, therefore many
Externí odkaz:
https://doaj.org/article/e4ff2eb404ce462e9946f467b81156d6
Autor:
Alfonso Serrano Del Valle, Manuel Beltrán-Visiedo, Victoria de Poo-Rodríguez, Nelia Jiménez-Alduán, Gemma Azaceta, Rosana Díez, Beatriz Martínez-Lázaro, Isabel Izquierdo, Luis Palomera, Javier Naval, Alberto Anel, Isabel Marzo
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Immunogenic cell death (ICD) has been proposed to be a crucial process for antitumor immunosurveillance. ICD is characterized by the exposure and emission of Damage Associated Molecular Patterns (DAMP), including calreticulin (CRT). A positive correl
Externí odkaz:
https://doaj.org/article/c49199a3f6714ed998461eab0fbb19a5
Publikováno v:
Cells, Vol 12, Iss 5, p 800 (2023)
Evasion of apoptosis is one of the hallmarks of cancer cells. Proteins of the Bcl-2 family are key regulators of the intrinsic pathway of apoptosis, and alterations in some of these proteins are frequently found in cancer cells. Permeabilization of t
Externí odkaz:
https://doaj.org/article/36bf7260db7a4524bbe708666314f03a
Autor:
Chantal Reina-Ortiz, Michael Constantinides, Alexis Fayd-Herbe-de-Maudave, Jessy Présumey, Javier Hernandez, Guillaume Cartron, David Giraldos, Rosana Díez, Isabel Izquierdo, Gemma Azaceta, Luis Palomera, Isabel Marzo, Javier Naval, Alberto Anel, Martín Villalba
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
In this study we evaluated the potential of expanded NK cells (eNKs) from two sources combined with the mAbs daratumumab and pembrolizumab to target primary multiple myeloma (MM) cells ex vivo. In order to ascertain the best source of NK cells, we ex
Externí odkaz:
https://doaj.org/article/c66d7fd744d64dde8fe77da679284058
Autor:
Patricia Guerrero-Ochoa, Raquel Ibáñez-Pérez, Germán Berbegal-Pinilla, Diederich Aguilar, Isabel Marzo, Francisco Corzana, Martha Minjárez-Sáenz, Javier Macías-León, Blanca Conde, Javier Raso, Ramón Hurtado-Guerrero, Alberto Anel
Publikováno v:
Biomedicines, Vol 10, Iss 6, p 1223 (2022)
Two granulysin (GRNLY) based immunotoxins were generated, one containing the scFv of the SM3 mAb (SM3GRNLY) and the other the scFv of the AR20.5 mAb (AR20.5GRNLY). These mAb recognize different amino acid sequences of aberrantly O-glycosylated MUC1,
Externí odkaz:
https://doaj.org/article/3c78f91eec174fcd91fca34c57a58985
Autor:
Chantal Reina-Ortiz, David Giraldos, Gemma Azaceta, Luis Palomera, Isabel Marzo, Javier Naval, Martín Villalba, Alberto Anel
Publikováno v:
Cells, Vol 11, Iss 3, p 392 (2022)
Natural killer (NK) cell-based therapies have emerged as promising anticancer treatments due to their potency as cytolytic effectors and synergy with concurrent treatments. Multiple myeloma (MM) is an aggressive B-cell malignancy that, despite develo
Externí odkaz:
https://doaj.org/article/8039a1f818234d8d920bd69c45d4c004
Autor:
Guillermo Canudo-Barreras, Lourdes Ortego, Anabel Izaga, Isabel Marzo, Raquel P. Herrera, M. Concepción Gimeno
Publikováno v:
Molecules, Vol 26, Iss 22, p 6891 (2021)
In this work, two thiourea ligands bearing a phosphine group in one arm and in the other a phenyl group (T2) or 3,5-di-CF3 substituted phenyl ring (T1) have been prepared and their coordination to Au and Ag has been studied. A different behavior is o
Externí odkaz:
https://doaj.org/article/d11967cdcc4a40f89dfe89e6028e5689
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1382 (2021)
Photodynamic therapy (PDT) is a cancer treatment still bearing enormous prospects of improvement. Within the toolbox of PDT, developing photosensitizers (PSs) that can specifically reach tumor cells and promote the generation of high concentration of
Externí odkaz:
https://doaj.org/article/0d2cfd8cac4546468478a13edc4226cf