Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Isabel Martinez-Pena y Valenzuela"'
Publikováno v:
Molecular Metabolism, Vol 36, Iss , Pp - (2020)
Objective: A sustained high fat diet in mice mimics many features of human obesity. We used male and female Non-Swiss albino mice to investigate the impact of short and long-term high-fat diet-(HFD)-induced obesity on the peripheral neuromuscular jun
Externí odkaz:
https://doaj.org/article/598c9b777cd14cd998d3985f07278a6a
Autor:
Saul Herranz-Martin, Jayanth Chandran, Katherine Lewis, Padraig Mulcahy, Adrian Higginbottom, Callum Walker, Isabel Martinez-Pena y Valenzuela, Ross A. Jones, Ian Coldicott, Tommaso Iannitti, Mohammed Akaaboune, Sherif F. El-Khamisy, Thomas H. Gillingwater, Pamela J. Shaw, Mimoun Azzouz
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 7, Pp 859-868 (2017)
Intronic GGGGCC repeat expansions in C9orf72 are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Two major pathologies stemming from the hexanucleotide RNA expansions (HREs) have been identified
Externí odkaz:
https://doaj.org/article/3b09a5da67e5486faef92f4f057cb7f5
Publikováno v:
Cells, Vol 10, Iss 2, p 358 (2021)
The clustering and maintenance of nicotinic acetylcholine receptors (AChRs) at high density in the postsynaptic membrane is a hallmark of the mammalian neuromuscular junction (NMJ). The regulation of receptor density/turnover rate at synapses is one
Externí odkaz:
https://doaj.org/article/795cf6485ffc468eaa8959a21cc423d2
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e81311 (2013)
The steady state of the acetylcholine receptor (AChR) density at the neuromuscular junction (NMJ) is critical for efficient and reliable synaptic transmission. However, little is known about signaling molecules involved in regulating the equilibrium
Externí odkaz:
https://doaj.org/article/6c29e79c915c4b93a06917c61e630e74
Autor:
Isabel Martinez-Pena y Valenzuela, Po-Ju Chen, Joseph Barden, Olivia Kosloski, Mohammed Akaaboune
Publikováno v:
Hum Mol Genet
α-syntrophin (α-syn) and α-dystrobrevin (α-dbn), two components of the dystrophin–glycoprotein complex, are essential for the maturation and maintenance of the neuromuscular junction (NMJ) and mice deficient in either α-syn or α-dbn exhibit s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02118a4208d62cfac3e40121147f3139
https://doi.org/10.1093/hmg/ddac041
https://doi.org/10.1093/hmg/ddac041
Autor:
Thomas H. Gillingwater, Callum Walker, Mohammed Akaaboune, Adrian Higginbottom, Sherif F. El-Khamisy, Saul Herranz-Martin, Mimoun Azzouz, Tommaso Iannitti, Pamela J. Shaw, Jayanth S. Chandran, Katherine E. Lewis, Isabel Martinez-Pena y Valenzuela, Padraig J. Mulcahy, Ian Coldicott, Ross A. Jones
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 7, Pp 859-868 (2017)
Herranz-Martin, S, Chandran, J, Lewis, K, Mulcahy, P, Higginbottom, A, Walker, C, Valenzuela, I M-P Y, Jones, R, Coldicott, I, Iannitti, T, Akaaboune, M, El-Khamisy, S F, Gillingwater, T H, Shaw, P J & Azzouz, M 2017, ' Viral delivery of C9ORF72 hexanucleotide repeat expansions in mice lead to repeat length dependent neuropathology and behavioral deficits ', Disease Models and Mechanisms . https://doi.org/10.1242/dmm.029892
Herranz-Martin, S, Chandran, J, Lewis, K, Mulcahy, P, Higginbottom, A, Walker, C, Valenzuela, I M-P Y, Jones, R, Coldicott, I, Iannitti, T, Akaaboune, M, El-Khamisy, S F, Gillingwater, T H, Shaw, P J & Azzouz, M 2017, ' Viral delivery of C9ORF72 hexanucleotide repeat expansions in mice lead to repeat length dependent neuropathology and behavioral deficits ', Disease Models and Mechanisms . https://doi.org/10.1242/dmm.029892
Intronic GGGGCC repeat expansions in C9orf72 are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Two major pathologies stemming from the hexanucleotide RNA expansions (HREs) have been identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98cfac7c128b02d4a6edc4695c52ce55
http://dmm.biologists.org/content/10/7/859
http://dmm.biologists.org/content/10/7/859
Publikováno v:
Molecular Metabolism, Vol 36, Iss, Pp-(2020)
Molecular Metabolism
Molecular Metabolism
Objective A sustained high fat diet in mice mimics many features of human obesity. We used male and female Non-Swiss albino mice to investigate the impact of short and long-term high-fat diet-(HFD)-induced obesity on the peripheral neuromuscular junc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0341ead9d4b2fc07c830cd0464b21c9b
https://doi.org/10.1016/j.molmet.2020.100979
https://doi.org/10.1016/j.molmet.2020.100979
Autor:
Stefan Sladecek, Niels Galjart, Isabel Martinez-Pena y Valenzuela, Ihor Smal, Katrin Martin, Hans Rudolf Brenner, Mohammed Akaaboune, Saonli Basu
Publikováno v:
Molecular Biology of the Cell
Molecular Biology of the Cell, 26(5), 938-951. American Society for Cell Biology
Molecular Biology of the Cell, 26(5), 938-951. American Society for Cell Biology
A novel mechanism is described for the agrin-mediated focal delivery of acetylcholine receptors (AChRs) to the postsynaptic membrane of the neuromuscular junction. Microtubule capture mediated by CLASP2 and its interaction partner, LL5β, and an inta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::465ead6e3e81ff0164626545b99f955e
http://www.molbiolcell.org/content/26/5/938.long
http://www.molbiolcell.org/content/26/5/938.long
A bimolecular fluorescence complementation (BiFC) approach was used to study the molecular interactions between different components of the postsynaptic protein complex at the neuromuscular junction of living mice. We show that rapsyn forms complex w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5e90e4cdfdb99701d0c125725256e52
https://europepmc.org/articles/PMC5450190/
https://europepmc.org/articles/PMC5450190/
Autor:
Mohammed Akaaboune, Megan L. Cramer, Neha Singhal, Peter White, Paul T. Martin, Kelly E. Crowe, Paulus M. L. Janssen, Mi Lyang Kim, Deborah A. Zygmunt, Jessica Adair, Ying Jia, Isabel Martinez-Pena y Valenzuela, Rui Xu
Sarcopenia, the loss of muscle mass and strength during normal aging, involves coordinate changes in skeletal myofibers and the cells that contact them, including satellite cells and motor neurons. Here we show that the protein O-fucosyltransferase 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a2721d9c0185c2879a7b2394b12a00
https://europepmc.org/articles/PMC5477548/
https://europepmc.org/articles/PMC5477548/