Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Isabel M Vincent"'
Publikováno v:
ACS Omega, Vol 4, Iss 21, Pp 19199-19215 (2019)
Externí odkaz:
https://doaj.org/article/9bf99d26e3b0414497b42aa0e2805981
Autor:
Pieter C Steketee, Federica Giordani, Isabel M Vincent, Kathryn Crouch, Fiona Achcar, Nicholas J Dickens, Liam J Morrison, Annette MacLeod, Michael P Barrett
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009939 (2021)
Subspecies of the protozoan parasite Trypanosoma brucei are the causative agents of Human African Trypanosomiasis (HAT), a debilitating neglected tropical disease prevalent across sub-Saharan Africa. HAT case numbers have steadily decreased since the
Externí odkaz:
https://doaj.org/article/005c928361f64560b5b954accbc88a07
Autor:
Federica Giordani, Daniel Paape, Isabel M Vincent, Andrew W Pountain, Fernando Fernández-Cortés, Eva Rico, Ning Zhang, Liam J Morrison, Yvonne Freund, Michael J Witty, Rosemary Peter, Darren Y Edwards, Jonathan M Wilkes, Justin J J van der Hooft, Clément Regnault, Kevin D Read, David Horn, Mark C Field, Michael P Barrett
Publikováno v:
PLoS Pathogens, Vol 16, Iss 11, p e1008932 (2020)
Livestock diseases caused by Trypanosoma congolense, T. vivax and T. brucei, collectively known as nagana, are responsible for billions of dollars in lost food production annually. There is an urgent need for novel therapeutics. Encouragingly, promis
Externí odkaz:
https://doaj.org/article/a5d1aac4a0fd47b29679ea476bd015f8
Publikováno v:
Proteomes, Vol 3, Iss 4, Pp 328-346 (2015)
Antimony (SbIII) and miltefosine (MIL) are important drugs for the treatment of Leishmania parasite infections. The mitochondrion is likely to play a central role in SbIII and MIL induced cell death in this parasite. Enriched mitochondrial samples fr
Externí odkaz:
https://doaj.org/article/8368f1820d554604ab7591312b556e26
Autor:
Daniela Begolo, Isabel M Vincent, Federica Giordani, Ina Pöhner, Michael J Witty, Timothy G Rowan, Zakaria Bengaly, Kirsten Gillingwater, Yvonne Freund, Rebecca C Wade, Michael P Barrett, Christine Clayton
Publikováno v:
PLoS Pathogens, Vol 14, Iss 9, p e1007315 (2018)
Kinetoplastid parasites-trypanosomes and leishmanias-infect millions of humans and cause economically devastating diseases of livestock, and the few existing drugs have serious deficiencies. Benzoxaborole-based compounds are very promising potential
Externí odkaz:
https://doaj.org/article/e1674f3ac3f24f8baaf483e779b5f349
Autor:
Pieter C Steketee, Isabel M Vincent, Fiona Achcar, Federica Giordani, Dong-Hyun Kim, Darren J Creek, Yvonne Freund, Robert Jacobs, Kevin Rattigan, David Horn, Mark C Field, Annette MacLeod, Michael P Barrett
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 5, p e0006450 (2018)
The parasitic protozoan Trypanosoma brucei causes Human African Trypanosomiasis and Nagana in other mammals. These diseases present a major socio-economic burden to large areas of sub-Saharan Africa. Current therapies involve complex and toxic regime
Externí odkaz:
https://doaj.org/article/bf067d73fa9f4661ba5f3af2533cc24f
Autor:
Ning Zhang, Martin Zoltner, Ka-Fai Leung, Paul Scullion, Sebastian Hutchinson, Ricardo C Del Pino, Isabel M Vincent, Yong-Kang Zhang, Yvonne R Freund, Michael R K Alley, Robert T Jacobs, Kevin D Read, Michael P Barrett, David Horn, Mark C Field
Publikováno v:
PLoS Pathogens, Vol 14, Iss 2, p e1006850 (2018)
Recent development of benzoxaborole-based chemistry gave rise to a collection of compounds with great potential in targeting diverse infectious diseases, including human African Trypanosomiasis (HAT), a devastating neglected tropical disease. However
Externí odkaz:
https://doaj.org/article/15b9266be10f461686b0efc0aad70326
Autor:
Kevin M Rattigan, Andrew W Pountain, Clement Regnault, Fiona Achcar, Isabel M Vincent, Carl S Goodyear, Michael P Barrett
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194126 (2018)
Priming and activating immune stimuli have profound effects on macrophages, however, studies generally evaluate stimuli in isolation rather than in combination. In this study we have investigated the effects of pro-inflammatory and anti-inflammatory
Externí odkaz:
https://doaj.org/article/b4f18042a6cb4ffd80648fe1854f421e
Autor:
Roy Mwenechanya, Julie Kovářová, Nicholas J Dickens, Manikhandan Mudaliar, Pawel Herzyk, Isabel M Vincent, Stefan K Weidt, Karl E Burgess, Richard J S Burchmore, Andrew W Pountain, Terry K Smith, Darren J Creek, Dong-Hyun Kim, Galina I Lepesheva, Michael P Barrett
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 6, p e0005649 (2017)
Amphotericin B has emerged as the therapy of choice for use against the leishmaniases. Administration of the drug in its liposomal formulation as a single injection is being promoted in a campaign to bring the leishmaniases under control. Understandi
Externí odkaz:
https://doaj.org/article/6745f44e729541bfb242217950694ec9
Autor:
Christopher Fernandez-Prada, Isabel M Vincent, Marie-Christine Brotherton, Mathew Roberts, Gaétan Roy, Luis Rivas, Philippe Leprohon, Terry K Smith, Marc Ouellette
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 12, p e0005171 (2016)
Leishmania infantum is an etiological agent of the life-threatening visceral form of leishmaniasis. Liposomal amphotericin B (AmB) followed by a short administration of miltefosine (MF) is a drug combination effective for treating visceral leishmania
Externí odkaz:
https://doaj.org/article/8e118853d9804ec2b37f570048adf6e9