Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Isabel Lushbough"'
Autor:
Annie Delaunois, Matthew Abernathy, Warren D. Anderson, Kylie A. Beattie, Khuram W. Chaudhary, Julie Coulot, Vitalina Gryshkova, Simon Hebeisen, Mark Holbrook, James Kramer, Yuri Kuryshev, Derek Leishman, Isabel Lushbough, Elisa Passini, Will S. Redfern, Blanca Rodriguez, Eric I. Rossman, Cristian Trovato, Caiyun Wu, Jean‐Pierre Valentin
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 3, Pp 1133-1146 (2021)
Abstract We applied a set of in silico and in vitro assays, compliant with the Comprehensive In Vitro Proarrhythmia Assay (CiPA) paradigm, to assess the risk of chloroquine (CLQ) or hydroxychloroquine (OH‐CLQ)‐mediated QT prolongation and Torsade
Externí odkaz:
https://doaj.org/article/d703d6568c29415c8e2d93ccf47af5d0
Autor:
Vitalina Gryshkova, Isabel Lushbough, Jessica Palmer, Robert Burrier, Annie Delaunois, Elizabeth Donley, Jean-Pierre Valentin
Publikováno v:
Archives of Toxicology. 96:2033-2047
Identification of early biomarkers of heart injury and drug-induced cardiotoxicity is important to eliminate harmful drug candidates early in preclinical development and to prevent severe drug effects. The main objective of this study was to investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186c8b4dbca2fac35b14cce947b53c65
https://doi.org/10.1007/s00204-022-03280-8
https://doi.org/10.1007/s00204-022-03280-8
Autor:
Isabel Lushbough, Jean-Pierre Valentin, Vitalina Gryshkova, Simon Hebeisen, Cristian Trovato, Will S. Redfern, Khuram W. Chaudhary, Caiyun Wu, Eric I. Rossman, Kylie A. Beattie, Julie Coulot, Elisa Passini, Yuri A. Kuryshev, Warren D. Anderson, Blanca Rodriguez, Annie Delaunois, Derek J. Leishman, Matthew M. Abernathy, James Kramer, Mark Holbrook
Publikováno v:
Clinical and Translational Science
Clinical and Translational Science, Vol 14, Iss 3, Pp 1133-1146 (2021)
Clinical and Translational Science, Vol 14, Iss 3, Pp 1133-1146 (2021)
We applied a set of in silico and in vitro assays, compliant with the CiPA (Comprehensive In Vitro Proarrhythmia Assay) paradigm, to assess the risk of chloroquine or hydroxychloroquine‐mediated QT prolongation and Torsades de Pointes (TdP), alone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::581ff6229742ba87f71f81a342b9f06c
http://europepmc.org/articles/PMC8014548
http://europepmc.org/articles/PMC8014548
Autor:
Alvaro Cardenas, Annie Delaunois, Isabel Lushbough, Vitalina Gryshkova, Jean-Pierre Valentin, Julia Roquigny, Martin Lowe
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 111:107023
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05e200a3d3eb8dcc8a55ab975dddba3d
https://doi.org/10.1016/j.vascn.2021.107023
https://doi.org/10.1016/j.vascn.2021.107023
Applying CiPA paradigm for assessing proarrhythmia risk of Covid-19 current off-label used therapies
Autor:
Cristian Trovato, Blanca Rodriguez, Jean-Pierre Valentin, Simon Hebeisen, Annie Delaunois, Elisa Passini, Isabel Lushbough, Vitalina Gryshkova
Publikováno v:
Journal of Pharmacological and Toxicological Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6378bdcde3d44dcd845a38e60e95ec60
http://europepmc.org/articles/PMC8483645
http://europepmc.org/articles/PMC8483645