Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Isabel K. Macdonald"'
Autor:
Catrin H Middleton, William Irving, John F R Robertson, Andrea Murray, Celine B Parsy-Kowalska, Isabel K Macdonald, Jane McElveen, Jared Allen, Graham F Healey, Brian J Thomson, Stephen J Ryder, Stefan Holdenrieder, Caroline J Chapman
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e103867 (2014)
BACKGROUND: Individuals with liver disease, and especially those with Hepatitis B or C, are at an increased risk of developing hepatocellular carcinoma (HCC) which is the third most common cause of cancer-related death worldwide. Inadequate screening
Externí odkaz:
https://doaj.org/article/4dca7442513c4446a6c64c6c158599b5
Autor:
Isabel K Macdonald, Jared Allen, Andrea Murray, Celine B Parsy-Kowalska, Graham F Healey, Caroline J Chapman, Herbert F Sewell, John F R Robertson
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40759 (2012)
An assay employing a panel of tumor-associated antigens has been validated and is available commercially (EarlyCDT®-Lung) to aid the early detection of lung cancer by measurement of serum autoantibodies. The high throughput (HTP) strategy described
Externí odkaz:
https://doaj.org/article/30b6bdc9b68c4fcf9e3b714380df206a
Autor:
Isabel K Macdonald, Andrea Murray, Graham F Healey, Celine B Parsy-Kowalska, Jared Allen, Jane McElveen, Chris Robertson, Herbert F Sewell, Caroline J Chapman, John F R Robertson
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51002 (2012)
BackgroundThe National Lung Screening Trial showed that CT screening for lung cancer led to a 20% reduction in mortality. However, CT screening has a number of disadvantages including low specificity. A validated autoantibody assay is available comme
Externí odkaz:
https://doaj.org/article/8438960788f54e9abee9c438965f1446
Autor:
Isabel K Macdonald, Maria Harkiolaki, Lawrence Hunt, Timothy Connelley, A Victoria Carroll, Niall D MacHugh, Simon P Graham, E Yvonne Jones, W Ivan Morrison, Darren R Flower, Shirley A Ellis
Publikováno v:
PLoS Pathogens, Vol 6, Iss 10, p e1001149 (2010)
T cell receptor (TCR) recognition of peptide-MHC class I (pMHC) complexes is a crucial event in the adaptive immune response to pathogens. Peptide epitopes often display a strong dominance hierarchy, resulting in focusing of the response on a limited
Externí odkaz:
https://doaj.org/article/dc0bc3cc205e45e6bb0790896cba9fc0
Autor:
Valerie A Walshe, Channa K Hattotuwagama, Irini A Doytchinova, Mailee Wong, Isabel K Macdonald, Arend Mulder, Frans H J Claas, Pierre Pellegrino, Jo Turner, Ian Williams, Emma L Turnbull, Persephone Borrow, Darren R Flower
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e8095 (2009)
Predictive models of peptide-Major Histocompatibility Complex (MHC) binding affinity are important components of modern computational immunovaccinology. Here, we describe the development and deployment of a reliable peptide-binding prediction method
Externí odkaz:
https://doaj.org/article/6c512875ea134bdf8f3599e92748472d
Publikováno v:
Journal of Cancer Therapy. :506-517
Background: Low-dose computed tomography (CT) screening reduces lung cancer mortality but costs are prohibitive for most healthcare budgets due to high false positive rates. An adjunctive test able to distinguish malignant from benign pulmonary nodul
Publikováno v:
Trends in cancer. 3(3)
Cancer cells can induce an immunological response resulting in the production of tumor-associated (TA) autoantibodies. These serum immunobiomarkers have been detected for a range of cancers at an early stage before the development of clinical symptom
Autor:
Isabel K. Macdonald, Emma J. Murphy, Peter C. E. Moody, Emma Lloyd Raven, Katherine A. Brown, Clive Metcalfe
Isoniazid (INH, isonicotinic acid hydrazine) is one of only two therapeutic agents effective in treating tuberculosis. This prodrug is activated by the heme enzyme catalase peroxidase (KatG) endogenous to Mycobacterium tuberculosis but the mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea2eab6ef2bf0776837a867650a92e9
https://ora.ox.ac.uk/objects/uuid:ca83589e-71ba-4cf0-a097-688a99de0e28
https://ora.ox.ac.uk/objects/uuid:ca83589e-71ba-4cf0-a097-688a99de0e28
Autor:
Isabel K. Macdonald, Clive Metcalfe, Sandip K. Badyal, Igor Efimov, Peter C. E. Moody, Emma Lloyd Raven, Andrea Gumiero
We test the hypothesized pathway by which protons are passed from the substrate, ascorbate, to the ferryl oxygen in the heme enzyme ascorbate peroxidase (APX). The role of amino acid side chains and bound solvent is demonstrated. We investigated solv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2badd05122d763b9d2cd39518ab3eb55
https://ora.ox.ac.uk/objects/uuid:66723f50-9e3c-4f1b-b866-dcd3347aaf63
https://ora.ox.ac.uk/objects/uuid:66723f50-9e3c-4f1b-b866-dcd3347aaf63
Autor:
M. Gordon Joyce, Isabel K. Macdonald, Harriet E. Seward, Katherine H. Sharp, Peter C. E. Moody, Sandip K. Badyal, Martin Mewies, Emma Lloyd Raven, Jaswir Basran
Publikováno v:
Journal of Biological Chemistry. 281:24512-24520
Conformational mobility of the distal histidine residue has been implicated for several different heme peroxidase enzymes, but unambiguous structural evidence is not available. In this work, we present mechanistic, spectroscopic, and structural evide