Výsledky vyhledávání - "Isabel Huber-Ruano"

Akademický článek

Orally administered Odoribacter laneus improves glucose control and inflammatory profile in obese mice by depleting circulating succinate

Publikováno v: Microbiome, Vol 10, Iss 1, Pp 1-22 (2022)

Abstract Background Succinate is produced by both human cells and by gut bacteria and couples metabolism to inflammation as an extracellular signaling transducer. Circulating succinate is elevated in patients with obesity and type 2 diabetes and is l

Externí odkaz: https://doaj.org/article/a570aa898a594f34ad77716587a8d6a4

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Akademický článek

LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

LIF is a pleiotropic cytokine that promotes an immunosuppressive microenvironment and has critical functions in embryonic development. Here, the authors show that LIF regulates CD8+ T cell tumor infiltration in cancer by repressing CXCL19 and promoti

Externí odkaz: https://doaj.org/article/eafd754e38d148f4af2177cb43fd4fa5

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Therapeutic targeting of LIF overcomes macrophage mediated immunosuppression of the local tumor microenvironment

Autor: Robin M. Hallett, Ester Bonfill-Teixidor, Raffaella Iurlaro, Alexandra Arias, Swetha Raman, Peter Bayliss, Olga Egorova, Almudena Neva-Alejo, AJ Robert McGray, Esther Lau, Alexandre Bosch, Melissa Beilschmidt, Dorothea Maetzel, Johan Fransson, Isabel Huber-Ruano, Judit Anido, Jean-Philippe Julien, Patricia Giblin, Joan Seoane

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research.

Purpose:Leukemia inhibitory factor (LIF) is a multifunctional cytokine with numerous reported roles in cancer and is thought to drive tumor development and progression. Characterization of LIF and clinical-stage LIF inhibitors would increase our unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52114ccf48df1069fba559699b7a33bc
https://pubmed.ncbi.nlm.nih.gov/36441800

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Glycogen accumulation in adipocyte precursors from elderly and obese subjects triggers inflammation via SIRT1 /6 signaling

Autor: Margarida Terrón‐Puig, Isabel Huber‐Ruano, Joan Sabadell‐Basallote, Miriam Ejarque, Catalina Núñez‐Roa, Elsa Maymó‐Masip, Rosa Jorba, Carolina Serena, Joan Vendrell, Sonia Fernández‐Veledo

Publikováno v: Aging Cell. 21

Dysfunctional adipocyte precursors have emerged as key determinants for obesity- and aging-related inflammation, but the mechanistic basis remains poorly understood. Here, we explored the dysfunctional adipose tissue of elderly and obese individuals

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed77340009062dcfaa8fb4f4382286be
https://doi.org/10.1111/acel.13667

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LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy

Publikováno v: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Scientia
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Nature Communications
Recercat. Dipósit de la Recerca de Catalunya
instname
Repisalud
Instituto de Salud Carlos III (ISCIII)

Cancer response to immunotherapy depends on the infiltration of CD8+ T cells and the presence of tumor-associated macrophages within tumors. Still, little is known about the determinants of these factors. We show that LIF assumes a crucial role in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3562526c931f1c9279325cea163e8e9b
https://hdl.handle.net/20.500.12105/8322

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Abstract 1751: MSC-1 is a first-in-class humanized monoclonal antibody that modulates the tumor microenvironment by inhibiting a novel cancer immunotherapy target, LIF

Autor: Monica Pascual, Naimish Pandya, Joan Seoane, Kimberly Hoffman, Robin M. Hallett, Ada Sala, Angus M. Sinclair, Judit Anido, Vanessa Chiganças, Robert Wasserman, Patricia Giblin, Isabel Huber-Ruano, Johan E. S. Fransson, Jeanne Magram, Swetha Raman, Jean-Philippe Julien

Publikováno v: Cancer Research. 78:1751-1751

Leukemia Inhibitory Factor (LIF) is a member of the IL-6 family of cytokines and is involved in many physiological and pathological processes including the promotion of an immunosuppressive environment to support embryo implantation, down-regulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7db4780660e351b0d896ee08db7ab6c
https://doi.org/10.1158/1538-7445.am2018-1751

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A phase 1 study of MSC-1, a humanized anti-LIF monoclonal antibody, in patients with advanced solid tumors

Autor: Patricia Giblin, Judit Anido, Lillian L. Siu, Anna Spreafico, Jeanne Magram, Robert Wasserman, Alison M. Schram, José Baselga, Irene Brana, David M. Hyman, Robin Hallet, Joan Seoane, Isabel Huber Ruano, Kimberly Hoffman, Josep Tabernero, Naimish Pandya

Publikováno v: Journal of Clinical Oncology. 36:TPS2602-TPS2602

TPS2602Background: Leukemia Inhibitory Factor (LIF) is a pleiotropic cytokine involved in many physiological and pathological processes. LIF is highly expressed in a subset of tumors across multipl...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6f2498b8124482115efd1c080bb3fad
https://doi.org/10.1200/jco.2018.36.15_suppl.tps2602

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