Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Isabel Hilbrich"'
Autor:
Max Holzer, Nico Schade, Ansgar Opitz, Isabel Hilbrich, Jens Stieler, Tim Vogel, Valentina Neukel, Moritz Oberstadt, Frank Totzke, Christoph Schächtele, Wolfgang Sippl, Andreas Hilgeroth
Publikováno v:
Molecules, Vol 23, Iss 9, p 2335 (2018)
The current number of drugs available for the treatment of Alzheimer’s disease (AD) is strongly limited and their benefit for therapy is given only in the early state of the disease. An effective therapy should affect those processes which mainly c
Externí odkaz:
https://doaj.org/article/540d8ad9361745d1b4fc2ae7d1220821
Autor:
Lydia Herrmann, Caspar Wiegmann, Annika Arsalan-Werner, Isabel Hilbrich, Carsten Jäger, Katharina Flach, Anne Suttkus, Ingolf Lachmann, Thomas Arendt, Max Holzer
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119423 (2015)
Defects in intracellular transport are implicated in the pathogenesis of Alzheimer's disease (AD). Hook proteins are a family of cytoplasmic linker proteins that participate in endosomal transport. In this study we show that Hook1 and Hook3 are expre
Externí odkaz:
https://doaj.org/article/3eecbc427092408e831b63c51935cfc7
Publikováno v:
Neuropathology
Vascular calcification is a common phenomenon in the elderly, predominantly appearing in the basal ganglia and in the lamina circumvoluta medullaris of the hippocampus. Calcifications are not an inherent feature of Alzheimer's disease. On the other h
Autor:
Max Holzer, Frank Totzke, Volkmar Tell, Wolfgang Sippl, Andreas Hilgeroth, Inna Slynko, Isabel Hilbrich, Christoph Schächtele
Publikováno v:
Current Alzheimer Research. 13:1330-1336
So far monotargeted therapies in Alzheimers disease (AD) led to insufficient results. Slight improvements in the AD symptomatics have been limited to patients in the early stage of the disease. So multitargeting approaches have been started addressin
Autor:
Torsten Bullmann, Jens Stieler, Thomas Arendt, János Hanics, Katja Reimann, Max Holzer, Tanja Petra Kretzschmann, Isabel Hilbrich, Alán Alpár, Gudrun Seeger
Publikováno v:
Hippocampus. 26:301-318
The microtubule-associated protein tau, in its hyperphosphorylated form, is the major component of paired helical filaments and other aggregates in neurodegenerative disorders commonly referred to as "tauopathies". Recent evidence, however, indicates
Autor:
Uwe Ueberham, Elke Ueberham, Max Holzer, Isabel Hilbrich, Susanne Rohn, Hildegard Gruschka, Martina K. Brückner, Susanne Wodischeck, Thomas Arendt
Publikováno v:
Neuropathology and Applied Neurobiology. 40:815-832
Aims Neurodegeneration in Alzheimer's disease (AD) is characterized by pathological protein aggregates and inadequate activation of cell cycle regulating proteins. Recently, Smad proteins were identified to control the expression of AD relevant prote
Autor:
Hanka Waschipky, Thomas Arendt, Marion Leonhardt, Andrea Schiffmann, Max Holzer, Katharina Flach, Martin Krüger, Lukas Y. Wick, Ulrich Gärtner, Isabel Hilbrich
Publikováno v:
Journal of Biological Chemistry. 287:43223-43233
The microtubule-associated protein Tau is mainly expressed in neurons, where it binds and stabilizes microtubules. In Alzheimer disease and other tauopathies, Tau protein has a reduced affinity toward microtubules. As a consequence, Tau protein detac
Autor:
Susanne Rohn, Uwe Ueberham, Pia Glöckner, Thomas Arendt, Katharina Dietrich, Elke Ueberham, Martina K. Brückner, Isabel Hilbrich
Publikováno v:
Neurobiology of aging. 33(12)
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by deregulation of neuronal cell cycle and differentiation control eventually resulting in cell death. During brain development, neuronal differentiation is regulated by Smad prot
Autor:
Lydia Herrmann, Thomas Arendt, Max Holzer, Michel Goedert, Isabel Hilbrich, Katharina Flach, Franziska Albrecht, Annika Arsalan-Werner, Ellen Ramminger
Publikováno v:
Biochimica et Biophysica Acta
Tau is the major microtubule-associated protein in neurons involved in microtubule stabilization in the axonal compartment. Changes in tau gene expression, alternative splicing and posttranslational modification regulate tau function and in tauopathi