Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Isabel González-Álvarez"'
Autor:
Bárbara Sánchez-Dengra, Elena García-Montoya, Isabel González-Álvarez, Marival Bermejo, Marta González-Álvarez
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1431 (2023)
Currently, the mechanisms involved in drug access to the central nervous system (CNS) are not completely elucidated, and research efforts to understand the behaviour of the therapeutic agents to access the blood–brain barrier continue with the utmo
Externí odkaz:
https://doaj.org/article/5b607623f67f45ab958ebb3b8225876b
Autor:
Isabel González-Álvarez, Bárbara Sánchez-Dengra, Raquel Rodriguez-Galvez, Alejandro Ruiz-Picazo, Marta González-Álvarez, Alfredo García-Arieta, Marival Bermejo
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2565 (2022)
Some years ago, excipients were considered inert substances irrelevant in the absorption process. However, years of study have demonstrated that this belief is not always true. In this study, the reasons for a bioequivalence failure between two formu
Externí odkaz:
https://doaj.org/article/c59935dd1d544a3f870878e72c51ca57
Publikováno v:
Animals, Vol 11, Iss 12, p 3521 (2021)
The development of new drugs or formulations for central nervous system (CNS) diseases is a complex pharmacologic and pharmacokinetic process; it is important to evaluate their access to the CNS through the blood–brain barrier (BBB) and their distr
Externí odkaz:
https://doaj.org/article/a67175dc2a0c414c8dd710a01e9d3fb1
Autor:
Elisa Poyatos-Racionero, Isabel González-Álvarez, Paola Sánchez-Moreno, Leopoldo Sitia, Francesca Gatto, Pier Paolo Pompa, Elena Aznar, Marta González-Álvarez, Ramón Martínez-Máñez, María Dolores Marcos, Andrea Bernardos
Publikováno v:
Pharmaceutics, Vol 13, Iss 7, p 982 (2021)
Mesoporous silica microparticles functionalized with lactose for the specific release of essential oil components (EOCs) in the small intestine are presented. In vitro and in vivo intestinal models were applied to validate the microparticles (M41-EOC
Externí odkaz:
https://doaj.org/article/627274480f744e05a20d574ba5e4bfc1
Autor:
Álvaro Fernández-Ochoa, Isabel Borrás-Linares, Almudena Pérez-Sánchez, Enrique Barrajón-Catalán, Isabel González-Álvarez, David Arráez-Román, Vicente Micol, Antonio Segura-Carretero
Publikováno v:
Journal of Functional Foods, Vol 33, Iss , Pp 202-210 (2017)
Phenolic compounds in rosemary have shown antiproliferative/cytotoxic activity against colorectal cancer cells. The aim of this work was to study in depth the absorption and metabolism of the compounds present in a rosemary extract. An in-situ perfus
Externí odkaz:
https://doaj.org/article/df63e3d6e7a74282b6a4055cb7fb4d3e
Autor:
Elisa Chilet-Rosell, Lucy A Parker, Ildefonso Hernández-Aguado, María Pastor-Valero, José Vilar, Isabel González-Álvarez, José María Salinas-Serrano, Fermina Lorente-Fernández, M Luisa Domingo, Blanca Lumbreras
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0221134 (2019)
ObjectivesTo determine the factors associated with lung cancer diagnosis and mortality after detecting a solitary pulmonary nodule (SPN) in routine clinical practice, in men and in women for both chest radiograph and CT.Materials and methodsA 5-year
Externí odkaz:
https://doaj.org/article/d7023e9c90e4497ba3cf541f70c7bce6
Autor:
Arik Dahan, Isabel González-Álvarez
Publikováno v:
Pharmaceutics, Vol 13, Iss 2, p 272 (2021)
The gastrointestinal tract (GIT) can be broadly divided into several regions: the stomach, the small intestine (which is subdivided to duodenum, jejunum, and ileum), and the colon. The conditions and environment in each of these segments, and even wi
Externí odkaz:
https://doaj.org/article/23e52f1fc2c4488bb909ffbc3c0a398f
Autor:
Andrés Figueroa-Campos, Bárbara Sánchez-Dengra, Virginia Merino, Arik Dahan, Isabel González-Álvarez, Alfredo García-Arieta, Marta González-Álvarez, Marival Bermejo
Publikováno v:
Pharmaceutics, Vol 12, Iss 7, p 633 (2020)
The main objective of this investigation was to develop an in vitro–in vivo correlation (IVIVC) for immediate release candesartan cilexetil formulations by designing an in vitro dissolution test to be used as development tool. The IVIVC could be us
Externí odkaz:
https://doaj.org/article/645b2d48b927437397ac2921d4809d20
Autor:
Elisa Poyatos-Racionero, Isabel González-Álvarez, Marta González-Álvarez, Ramón Martínez-Máñez, M. Dolores Marcos, Andrea Bernardos, Elena Aznar
Publikováno v:
Nanomaterials, Vol 10, Iss 7, p 1290 (2020)
In recent decades, the versatility of mesoporous silica particles and their relevance to develop controlled release systems have been demonstrated. Within them, gated materials able to modulate payload delivery represent great advantages. However, th
Externí odkaz:
https://doaj.org/article/a405b91fec154a95975adcc94e402fdf
Autor:
Milica Markovic, Moran Zur, Noa Fine-Shamir, Ester Haimov, Isabel González-Álvarez, Arik Dahan
Publikováno v:
Pharmaceutics, Vol 12, Iss 3, p 295 (2020)
The main factors influencing the absorption of orally administered drugs are solubility and permeability, which are location-dependent and may vary along the gastrointestinal tract (GIT). The purpose of this work was to investigate segmental-dependen
Externí odkaz:
https://doaj.org/article/16cb103f379b400084206ad226eb71e5