Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Isabel Goncalves"'
Autor:
Kunihiko Aizawa, Alun D. Hughes, Francesco Casanova, Kim M. Gooding, Phillip E. Gates, David M. Mawson, Jennifer Williams, Isabel Goncalves, Jan Nilsson, Faisel Khan, Helen M. Colhoun, Carlo Palombo, Kim H. Parker, Angela C. Shore
Publikováno v:
ESC Heart Failure, Vol 11, Iss 5, Pp 3290-3298 (2024)
Abstract Aims Parameters derived from reservoir‐excess pressure analysis have been demonstrated to predict cardiovascular events. Thus, altered reservoir‐excess pressure parameters could have a detrimental effect on highly‐perfused organs like
Externí odkaz:
https://doaj.org/article/90221f9627714e60b5164d980c6f572e
Autor:
Helena Grauen Larsen, Jiangming Sun, Marketa Sjögren, Yan Borné, Gunnar Engström, Peter Nilsson, Marju Orho-Melander, Isabel Goncalves, Jan Nilsson, Olle Melander, Alexandru Schiopu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The receptor for advanced glycation endproducts (RAGE) has pro-inflammatory and pro-atherogenic effects. Low plasma levels of soluble RAGE (sRAGE), a decoy receptor for RAGE ligands, have been associated with increased risk for major adverse
Externí odkaz:
https://doaj.org/article/b96798e6060345dba3b6beb9bdf3cdb3
Autor:
Göran Bergström, Eva Hagberg, Elias Björnson, Martin Adiels, Carl Bonander, Ulf Strömberg, Jonas Andersson, Mattias Brunström, Carl‐Johan Carlhäll, Gunnar Engström, David Erlinge, Isabel Goncalves, Anders Gummesson, Emil Hagström, Ola Hjelmgren, Stefan James, Magnus Janzon, Lena Jonasson, Lars Lind, Martin Magnusson, Viktor Oskarsson, Johan Sundström, Per Svensson, Stefan Söderberg, Raquel Themudo, Carl Johan Östgren, Tomas Jernberg
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 14 (2024)
Background Coronary atherosclerosis detected by imaging is a marker of elevated cardiovascular risk. However, imaging involves large resources and exposure to radiation. The aim was, therefore, to test whether nonimaging data, specifically data that
Externí odkaz:
https://doaj.org/article/c39fba8baf7048adb14893a16c48fe16
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5911 (2024)
There is a lack of studies aiming to assess cellular a disintegrin and metalloproteinase-17 (ADAM-17) activity in COVID-19 patients and the eventual associations with the shedding of membrane-bound angiotensin-converting enzyme 2 (mACE2). In addition
Externí odkaz:
https://doaj.org/article/1e20a2740f6f4b629e3d41e829a2d4a1
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
IntroductionElevated red cell distribution width (RDW) has been associated with a range of health outcomes. This study aims to examine prognostic and etiological roles of RDW levels, both phenotypic and genetic predisposition, in predicting cardiovas
Externí odkaz:
https://doaj.org/article/f5ed4582cd0c4b138fb5fa12a9e08bc4
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 15879 (2023)
High levels of ADAM17 activity have emerged as an important mediator in severe COVID-19. This study aims to characterize eventual causal relationships between ADAM17 and COVID-19. Using Mendelian randomization analyses, we examined the causal effects
Externí odkaz:
https://doaj.org/article/503fa4b8f46f46d0a745d7ac424c0717
Autor:
Emmelie Cansby, Sima Kumari, Mara Caputo, Ying Xia, Rando Porosk, Jonathan Robinson, Hao Wang, Britt-Marie Olsson, Josefine Vallin, Julie Grantham, Ursel Soomets, L. Thomas Svensson, Carina Sihlbom, Hanns-Ulrich Marschall, Andreas Edsfeldt, Isabel Goncalves, Margit Mahlapuu
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Silencing of STK25, an STE20-type kinase, in human aortic endothelial and smooth muscle cells reduces lipid accumulation and suppresses inflammation and fibrotic pathways, ultimately exerting atheroprotective effects.
Externí odkaz:
https://doaj.org/article/c671ada46a694cea94aa6e66b65dc4a6
Autor:
Michael Lacy, Christina Bürger, Annelie Shami, Maiwand Ahmadsei, Holger Winkels, Katrin Nitz, Claudia M. van Tiel, Tom T. P. Seijkens, Pascal J. H. Kusters, Ela Karshovka, Koen H. M. Prange, Yuting Wu, Sanne L. N. Brouns, Sigrid Unterlugauer, Marijke J. E. Kuijpers, Myrthe E. Reiche, Sabine Steffens, Andreas Edsfeldt, Remco T. A. Megens, Johan W. M. Heemskerk, Isabel Goncalves, Christian Weber, Norbert Gerdes, Dorothee Atzler, Esther Lutgens
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Previous studies have shown that the CD40L-CD40 signaling axis plays a role in atherosclerosis. Here the authors investigate the cell-specific functions of the most relevant CD40L-expressing cell types in atherosclerosis. Deficiency of T cell-derived
Externí odkaz:
https://doaj.org/article/77cc9364f8ea48a78af4b15a8220d6c9
Autor:
Pratibha Singh, Isabel Goncalves, Christoffer Tengryd, Mihaela Nitulescu, Ana F. Persson, Fong To, Eva Bengtsson, Petr Volkov, Marju Orho-Melander, Jan Nilsson, Andreas Edsfeldt
Publikováno v:
Cardiovascular Diabetology, Vol 19, Iss 1, Pp 1-12 (2020)
Abstract Background Type 2 diabetes (T2D) patients are at a greater risk of cardiovascular events due to aggravated atherosclerosis. Oxidized LDL (oxLDL) has been shown to be increased in T2D plaques and suggested to contribute to plaque ruptures. De
Externí odkaz:
https://doaj.org/article/123963742b5544f787083e19a494016d
Autor:
Gunnar Engström, Viktor Hamrefors, Artur Fedorowski, Anders Persson, Maria E. Johansson, Ellen Ostenfeld, Isabel Goncalves, Hanna Markstad, Linda S. B. Johnson, Margaretha Persson, Jonas Carlson, Pyotr G. Platonov
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 7 (2022)
Background The cardiovagal function can be assessed by quantification of respiratory sinus arrhythmia (RSA) during a deep breathing test. However, population studies of RSA and coronary atherosclerosis are lacking. This population‐based study exami
Externí odkaz:
https://doaj.org/article/7f29eedbed8241fab4df239ad2eb7151