Sulconazole inhibits PD-1 expression in immune cells and cancer cells malignant phenotype through NF-κB and calcium activity repression

Autor: Simon Pernot, Mercedes Tomé, Isabel Galeano-Otero, Serge Evrard, Iker Badiola, Frederic Delom, Delphine Fessart, Tarik Smani, Geraldine Siegfried, Bruno O. Villoutreix, Abdel-Majid Khatib

Publikováno v: Frontiers in Immunology, Vol 14 (2024)

The overexpression of the immunoinhibitory receptor programmed death-1 (PD1) on T-cells is involved in immune evasion in cancer. The use of anti-PD-1/PDL-1 strategy has deeply changed the therapies of cancers and patient survival. However, their effi

Externí odkaz: https://doaj.org/article/90571bd8e03445089bd4c69afb1017e6

Predicted Value of MicroRNAs, Vascular Endothelial Growth Factor, and Intermediate Monocytes in the Left Adverse Ventricular Remodeling in Revascularized ST-Segment Elevation Myocardial Infarction Patients

Autor: Raquel Del Toro, Isabel Galeano-Otero, Elisa Bevilacqua, Francisco Guerrero-Márquez, Debora Falcon, Agustín Guisado-Rasco, Luis Díaz-de la Llera, Gonzalo Barón-Esquivias, Tarik Smani, Antonio Ordóñez-Fernández

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 9 (2022)

BackgroundPrimary percutaneous coronary intervention (PPCI) in patients with ST-segment elevation myocardial infarction (STEMI) improves the survival of patients; nevertheless, some patients develop left ventricular adverse remodeling (LVAR) a few mo

Externí odkaz: https://doaj.org/article/5e30ad1f82bb4e24a0a420338eb91d56

SARAF and Orai1 Contribute to Endothelial Cell Activation and Angiogenesis

Autor: Isabel Galeano-Otero, Raquel Del Toro, Abdel-Majid Khatib, Juan Antonio Rosado, Antonio Ordóñez-Fernández, Tarik Smani

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Angiogenesis is a multistep process that controls endothelial cells (ECs) functioning to form new blood vessels from preexisting vascular beds. This process is tightly regulated by pro-angiogenic factors, such as vascular endothelial growth factor (V

Externí odkaz: https://doaj.org/article/a209e74285db4c6e88cbe0052f99559f

TRPC Channels: Dysregulation and Ca2+ Mishandling in Ischemic Heart Disease

Autor: Débora Falcón, Isabel Galeano-Otero, Marta Martín-Bórnez, María Fernández-Velasco, Isabel Gallardo-Castillo, Juan A. Rosado, Antonio Ordóñez, Tarik Smani

Publikováno v: Cells, Vol 9, Iss 1, p 173 (2020)

Transient receptor potential canonical (TRPC) channels are ubiquitously expressed in excitable and non-excitable cardiac cells where they sense and respond to a wide variety of physical and chemical stimuli. As other TRP channels, TRPC channels may f

Externí odkaz: https://doaj.org/article/33c46d8de08e416994dd7849f8a2d236

TRPC and TRPV Channels’ Role in Vascular Remodeling and Disease

Autor: Tarik Smani, Raquel del Toro, Isabel Galeano-Otero, Marta Martín-Bórnez

Publikováno v: International Journal of Molecular Sciences
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
International Journal of Molecular Sciences, Vol 21, Iss 6125, p 6125 (2020)

Transient receptor potentials (TRPs) are non-selective cation channels that are widely expressed in vascular beds. They contribute to the Ca2+ influx evoked by a wide spectrum of chemical and physical stimuli, both in endothelial and vascular smooth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9c84135874f73b98784f92e84317d00
http://europepmc.org/articles/PMC7503586