Výsledky vyhledávání - "Isabel F. Amaral"

Akademický článek

Hydrogel-Assisted Antisense LNA Gapmer Delivery for In Situ Gene Silencing in Spinal Cord Injury

Autor: Pedro M.D. Moreno, Ana R. Ferreira, Daniela Salvador, Maria T. Rodrigues, Marília Torrado, Eva D. Carvalho, Ulf Tedebark, Mónica M. Sousa, Isabel F. Amaral, Jesper Wengel, Ana P. Pêgo

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 11, Iss C, Pp 393-406 (2018)

After spinal cord injury (SCI), nerve regeneration is severely hampered due to the establishment of a highly inhibitory microenvironment at the injury site, through the contribution of multiple factors. The potential of antisense oligonucleotides (AO

Externí odkaz: https://doaj.org/article/b4a65d46d57a47d3873ab1bc90af99e7

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Hydrogel-Assisted Antisense LNA Gapmer Delivery for In Situ Gene Silencing in Spinal Cord Injury

Autor: Ana Paula Pêgo, Daniela Salvador, Ulf Tedebark, Jesper Wengel, Marília Torrado, Isabel F. Amaral, Eva D. Carvalho, Ana Rita Ferreira, Mónica Mendes Sousa, Maria T. Rodrigues, Pedro Moreno

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 11, Iss C, Pp 393-406 (2018)
Moreno, P M D, Ferreira, A R, Salvador, D, Rodrigues, M T, Torrado, M, Carvalho, E D, Tedebark, U, Sousa, M M, Amaral, I F, Wengel, J & Pêgo, A P 2018, ' Hydrogel-Assisted Antisense LNA Gapmer Delivery for In Situ Gene Silencing in Spinal Cord Injury ', Molecular Therapy-Nucleic Acids, vol. 11, pp. 393-406 . https://doi.org/10.1016/j.omtn.2018.03.009
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Molecular Therapy. Nucleic Acids

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c2d730d406cab3d2afdcfb09da2bb3
http://www.sciencedirect.com/science/article/pii/S2162253118300404

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Three-dimensional culture of single embryonic stem-derived neural/stem progenitor cells in fibrin hydrogels: neuronal network formation and matrix remodelling

Autor: Pedro Quelhas, Isabel F. Amaral, Ana R. Bento, Maria José Oliveira, Ana Paula Pêgo

Publikováno v: Journal of Tissue Engineering and Regenerative Medicine. 11:3494-3507

In an attempt to improve the efficacy of neural stem/progenitor cell (NSPC) based therapies, fibrin hydrogels are being explored to provide a favourable microenvironment for cell survival and differentiation following transplantation. In the present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a41ba733456a2169df85e0f081e9f3d9
https://doi.org/10.1002/term.2262

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Engineering Hydrogels with Affinity-Bound Laminin as 3D Neural Stem Cell Culture Systems

Autor: Andrés J. García, Woojin M. Han, Eduardo Conde-Sousa, Isabel F. Amaral, Andreia M Gonçalves, Daniela Barros, Ana Paula Pêgo

Publikováno v: Biomater Sci
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Laminin incorporation into biological or synthetic hydrogels has been explored to recapitulate the dynamic nature and biological complexity of neural stem cell (NSC) niches. However, the strategies currently explored for laminin immobilization within

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664506f0037d40589bb5031dd46c129f
https://hdl.handle.net/10216/122944

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Delivery of Antisense Oligonucleotides Mediated by a Hydrogel System: In Vitro and In Vivo Application in the Context of Spinal Cord Injury

Autor: Marília Torrado, Pedro Moreno, Teresa Rodrigues, Isabel F. Amaral, Ana Paula Pêgo

Publikováno v: Methods in Molecular Biology ISBN: 9781493996698

This work was supported by Fundacao para a Ciencia e a Tecnologia (FCT, Portugal) in the framework of the Harvard-Portugal. Medical School Program [HMSP-ICT/0020/2010]; Project NORTE-01-0145- FEDER-000008, supported by Norte Portugal Regional Operati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9dbbafa2d3fd9ef97adbde5fc26df137
https://doi.org/10.1007/978-1-4939-9670-4_12

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An affinity-based approach to engineer laminin-presenting cell instructive microenvironments

Autor: Paula Parreira, Ana Paula Pêgo, Eduardo Conde-Sousa, Joana Furtado, Frederico Ferreira-da-Silva, Isabel F. Amaral, M. Cristina L. Martins, Daniela Barros, Andrés J. García

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Biomaterials

Laminin immobilization into diverse biological and synthetic matrices has been explored to replicate the microenvironment of stem cell niches and gain insight into the role of extracellular matrix (ECM) on stem cell behavior. However, the site-specif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ab97ebbc73f763ebfebb7039c2ebbf
https://pubmed.ncbi.nlm.nih.gov/30509501

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Synthetic matrix enhances transplanted satellite cell engraftment in dystrophic and aged skeletal muscle with comorbid trauma

Autor: Woojin M. Han, Ana Paula Pêgo, Shadi Nakhai, Mahir Mohiuddin, Andrés J. García, Eunjung Shin, Isabel F. Amaral, Young C. Jang, Daniela Barros, Shannon E. Anderson

Publikováno v: Science Advances
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Synthetic designer matrix enhances muscle stem cell function and engraftment in injured dystrophic and aged skeletal muscles.
Muscle satellite cells (MuSCs) play a central role in muscle regeneration, but their quantity and function decline with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95b3e2c3d87c65fd31a705ec9463e86
https://pubmed.ncbi.nlm.nih.gov/30116776

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2.13 Chitosan ☆

Autor: Raquel Gonçalves, Isabel F. Amaral, Ana Paula Pêgo, Susana G. Santos, Pedro Moreno, Inês C. Gonçalves, Mário A. Barbosa

Chitosan is a derivative of chitin, obtained by its deacetylation. Chitin is the second most abundant polysaccharide in nature after cellulose. It constitutes the fibrous support of the endo and exoskeleton of many invertebrates. Chitosan is a linear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e128f5dfd6b4af81868db70d27e61229
https://doi.org/10.1016/b978-0-12-803581-8.10246-2

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Conjugation of the T1 sequence from CCN1 to fibrin hydrogels for therapeutic vascularization

Autor: Isabel F. Amaral, Cristina C. Barrias, Paulo Aguiar, Joana A. Loureiro, Ana Luísa Torres, Marta Pinto, Tânia Neto

Publikováno v: Materials Science and Engineering: C. 104:109847

Hydrogel matrices with angiogenic properties are much desirable for therapeutic vascularization strategies, namely to provide vascular supply to ischemic areas, transplanted cells, or bioengineered tissues. Here we report the pro-angiogenic effect of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac34c036047b58dc8ac58ca2c5f11c1a
https://doi.org/10.1016/j.msec.2019.109847

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Engineering Endochondral Bone:In VivoStudies

Autor: Serafim M. Oliveira, Dindo Q. Mijares, Gloria Turner, Isabel F. Amaral, Mário A. Barbosa, Cristina C. Teixeira

Publikováno v: Tissue Engineering Part A. 15:635-643

The use of biomaterials to replace lost bone has been a common practice for decades. More recently, the demands for bone repair and regeneration have pushed research into the use of cultured cells and growth factors in association with these material

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2baadbf8c7aa8746ef7655c39aa94be
https://doi.org/10.1089/ten.tea.2008.0052

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