Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Isabel English"'
Autor:
Nathalie Javidi-Sharifi, Jacqueline Martinez, Isabel English, Sunil K Joshi, Renata Scopim-Ribeiro, Shelton K Viola, David K Edwards V, Anupriya Agarwal, Claudia Lopez, Danielle Jorgens, Jeffrey W Tyner, Brian J Druker, Elie Traer
Publikováno v:
eLife, Vol 8 (2019)
Externí odkaz:
https://doaj.org/article/1676b10ade3b455f8c9d2a4bf4ea83a7
Autor:
Nathalie Javidi-Sharifi, Jacqueline Martinez, Isabel English, Sunil K Joshi, Renata Scopim-Ribeiro, Shelton K Viola, David K Edwards V, Anupriya Agarwal, Claudia Lopez, Danielle Jorgens, Jeffrey W Tyner, Brian J Druker, Elie Traer
Publikováno v:
eLife, Vol 8 (2019)
Protective signaling from the leukemia microenvironment leads to leukemia cell persistence, development of resistance, and disease relapse. Here, we demonstrate that fibroblast growth factor 2 (FGF2) from bone marrow stromal cells is secreted in exos
Externí odkaz:
https://doaj.org/article/1c66ad09cee24491a3ce0b7b0754affd
Autor:
Brian J. Druker, Melissa Wong, Jeffrey W. Tyner, Tibor Kovacsovics, Isabel English, Jennifer Dunlap, Anupriya Agarwal, Nathalie Javidi-Sharifi, Jacqueline Martinez, Elie Traer
Figure S1. FGFR1 is the most highly expressed FGFR in MOLM 14 and siRNA knock down of FGFR mRNA. Figure S2. FGF2 protection from FLT3 inhibitors is dependent upon FGFR expression. Figure S3. Matrix of AC220 and PD173074. Figure S4. STAT5 and ERK are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59787920b84e9b38ddc456935a0b2fce
https://doi.org/10.1158/0008-5472.22413735.v1
https://doi.org/10.1158/0008-5472.22413735.v1
Autor:
Brian J. Druker, Melissa Wong, Jeffrey W. Tyner, Tibor Kovacsovics, Isabel English, Jennifer Dunlap, Anupriya Agarwal, Nathalie Javidi-Sharifi, Jacqueline Martinez, Elie Traer
Supplemental Tables 1-4 are included in this file: Supplemental Table 1. Calculation of combination indexes to evaluate synergy. Supplemental Table 2. Genes tested with OHSU Knight Diagnostic Labs Supplemental Table 3. Patient characteristics studied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a66777d768aa0099b910c84a8dbf5b1
https://doi.org/10.1158/0008-5472.22413729
https://doi.org/10.1158/0008-5472.22413729
Autor:
Brian J. Druker, Melissa Wong, Jeffrey W. Tyner, Tibor Kovacsovics, Isabel English, Jennifer Dunlap, Anupriya Agarwal, Nathalie Javidi-Sharifi, Jacqueline Martinez, Elie Traer
This file contains the legends for Supplemental Figures 1-10.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4debcf43cd6f402c1330784401551ea4
https://doi.org/10.1158/0008-5472.22413738
https://doi.org/10.1158/0008-5472.22413738
Autor:
Brian J. Druker, Melissa Wong, Jeffrey W. Tyner, Tibor Kovacsovics, Isabel English, Jennifer Dunlap, Anupriya Agarwal, Nathalie Javidi-Sharifi, Jacqueline Martinez, Elie Traer
Supplementary materials and methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea77a76e7298bdd096ab77d3c7d1ac79
https://doi.org/10.1158/0008-5472.22413732.v1
https://doi.org/10.1158/0008-5472.22413732.v1
Autor:
Brian J. Druker, Melissa Wong, Jeffrey W. Tyner, Tibor Kovacsovics, Isabel English, Jennifer Dunlap, Anupriya Agarwal, Nathalie Javidi-Sharifi, Jacqueline Martinez, Elie Traer
Potent FLT3 inhibitors, such as quizartinib (AC220), have shown promise in treating acute myeloid leukemia (AML) containing FLT3 internal tandem duplication (ITD) mutations. However, responses are not durable and resistance develops within months. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c566f416c8c91c67d6e6640ab4e7dadd
https://doi.org/10.1158/0008-5472.c.6508800.v1
https://doi.org/10.1158/0008-5472.c.6508800.v1
Autor:
Jason M. Link, Carl Pelz, Patrick J. Worth, Sydney Owen, Dove Keith, Ellen M. Langer, Alison Grossblatt-Wait, Allison L. Creason, Julian Egger, Hannah Holly, Isabel English, Kevin MacPherson, Motoyuki Tsuda, Jeremy Goecks, Emek Demir, Adel Kardosh, Charles D. Lopez, Brett C. Sheppard, Alex Guimaraes, Brian Brinkerhoff, Terry K. Morgan, Gordon Mills, Jonathan Brody, Rosalie C. Sears
Background and AimsMetastatic pancreatic adenocarcinoma (mPDAC) is lethal, yet a subset of patients who have metastatic disease that spreads only to the lung have better outcomes. We identified unique transcriptomic and immune features that distingui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2fe88444e2e445222eb69ba2c01bf6e
https://doi.org/10.1101/2022.05.04.490552
https://doi.org/10.1101/2022.05.04.490552
Autor:
Daniel Bottomly, Nicola Long, Anna Reister Schultz, Stephen E. Kurtz, Cristina E. Tognon, Kara Johnson, Melissa Abel, Anupriya Agarwal, Sammantha Avaylon, Erik Benton, Aurora Blucher, Uma Borate, Theodore P. Braun, Jordana Brown, Jade Bryant, Russell Burke, Amy Carlos, Bill H. Chang, Hyun Jun Cho, Stephen Christy, Cody Coblentz, Aaron M. Cohen, Amanda d’Almeida, Rachel Cook, Alexey Danilov, Kim-Hien T. Dao, Michie Degnin, James Dibb, Christopher A. Eide, Isabel English, Stuart Hagler, Heath Harrelson, Rachel Henson, Hibery Ho, Sunil K. Joshi, Brian Junio, Andy Kaempf, Yoko Kosaka, Ted Laderas, Matt Lawhead, Hyunjung Lee, Jessica T. Leonard, Chenwei Lin, Evan F. Lind, Selina Qiuying Liu, Pierrette Lo, Marc M. Loriaux, Samuel Luty, Julia E. Maxson, Tara Macey, Jacqueline Martinez, Jessica Minnier, Andrea Monteblanco, Motomi Mori, Quinlan Morrow, Dylan Nelson, Justin Ramsdill, Angela Rofelty, Alexandra Rogers, Kyle A. Romine, Peter Ryabinin, Jennifer N. Saultz, David A. Sampson, Samantha L. Savage, Robert Schuff, Robert Searles, Rebecca L. Smith, Stephen E. Spurgeon, Tyler Sweeney, Ronan T. Swords, Aashis Thapa, Karina Thiel-Klare, Elie Traer, Jake Wagner, Beth Wilmot, Joelle Wolf, Guanming Wu, Amy Yates, Haijiao Zhang, Christopher R. Cogle, Robert H. Collins, Michael W. Deininger, Christopher S. Hourigan, Craig T. Jordan, Tara L. Lin, Micaela E. Martinez, Rachel R. Pallapati, Daniel A. Pollyea, Anthony D. Pomicter, Justin M. Watts, Scott J. Weir, Brian J. Druker, Shannon K. McWeeney, Jeffrey W. Tyner
Publikováno v:
Cancer Cell. 40:850-864.e9
Acute myeloid leukemia (AML) is a cancer of myeloid-lineage cells with limited therapeutic options. We previously combined ex vivo drug sensitivity with genomic, transcriptomic, and clinical annotations for a large cohort of AML patients, which facil
Publikováno v:
Cell
Impairment of protein phosphatases, including the family of serine/threonine phosphatases designated PP2A, is essential for the pathogenesis of many diseases, including cancer. The ability of PP2A to dephosphorylate hundreds of proteins is regulated