Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Isabel Dorronsoro"'
Autor:
Esther García-Palomero, Miguel Medina, Isabel Dorronsoro, Ana Martínez, Pilar Munoz-Ruiz, Rita Valenzuela, Paola Usán, María del Monte-Millán, Laura Rubio, Celia de Austria
Publikováno v:
Journal of Molecular Neuroscience. 30:85-88
The therapeutic potential of acetylcholinesterase (AChE) inhibitors has been strengthened recently by evidence showing that besides their role in cognitive function, they might contribute to slow down the neurodegeneration in Alzheimer's disease (AD)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59e53a120aac01c9152a413b67e7f74b
https://doi.org/10.1385/jmn:30:1:85
https://doi.org/10.1385/jmn:30:1:85
Autor:
Concepción Pérez, Ana Martínez, F. Javier Luque, Francisco J. Moreno, J. Luis Gelpi, Isabel Dorronsoro, Ana I. Gómez de Castro, Mercedes Alonso
Publikováno v:
Journal of Medicinal Chemistry. 48:7103-7112
The 2,4-disubstituted thiadiazolidinones (TDZD) are described as the first ATP-noncompetitive GSK-3 inhibitors. Following an SAR study about TDZD, different structural modifications in the heterocyclic ring aimed to test the influence of each heteroa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e22fd3412c106ab7565a70256f1d1d
https://doi.org/10.1021/jm040895g
https://doi.org/10.1021/jm040895g
Autor:
Isabel Dorronsoro, Esther García-Palomero, Maria del Monte, Diana Alonso, Ana Martínez, Ana Castro
Publikováno v:
Archiv der Pharmazie. 338:18-23
The synthesis of tacrine-thiadiazolidinone hybrids is described. These compounds are designed as dual acetylcholinesterase inhibitors binding simultaneously to the peripheral and catalytic sites of the enzyme. All tested compounds exhibit significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71702ca00ba9049dd9e7dc039cf20bd0
https://doi.org/10.1002/ardp.200400919
https://doi.org/10.1002/ardp.200400919
Publikováno v:
Expert Opinion on Therapeutic Patents. 13:1725-1732
Current treatment approaches in Alzheimer’s disease have been dominated by the use of acetylcholinesterase (AChE) inhibitors, which increase the acetylcholine concentration in the brain, thus alleviating the decline in cognitive and mental function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e86e535e43acdfe386ad02bcb6fde960
https://doi.org/10.1517/13543776.13.11.1725
https://doi.org/10.1517/13543776.13.11.1725
Autor:
Isabel Dorronsoro, Ana Martínez, María Isabel Rodríguez-Franco, Josep E. Baños, Albert Badia, Ana I. Gómez de Castro
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:2263-2268
The synthesis of O-propynyloximes of N-methylpiperidinone, 3-tropinone, and 3-quinuclidinone, containing several pyrazole frameworks is described, together with their muscarinic receptor affinities. Compounds derived from N-methylpiperidinone or 3-tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af57130b35a48f08501f6cb93eca5aab
https://doi.org/10.1016/s0968-0896(03)00111-1
https://doi.org/10.1016/s0968-0896(03)00111-1
Publikováno v:
Expert Opinion on Therapeutic Patents. 12:1527-1536
Glycogen synthase kinase-3 (GSK-3) has recently emerged, in the field of medicinal chemistry, as one of the most attractive therapeutic targets for the development of selective inhibitors as promising new drugs for numerous serious pathologies, inclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db5f5e9884e0b7bc1a7989f329f79ef5
https://doi.org/10.1517/13543776.12.10.1527
https://doi.org/10.1517/13543776.12.10.1527
Publikováno v:
Archiv der Pharmazie. 335:339-346
The synthesis of two series of 1-(but-2-ynyl)pyrazole containing a pyrrolidine or a diethylamine moiety, respectively, is described, together with their muscarinic receptor affinities.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d3ef2759cf1b47fc230590abfe57f45
https://doi.org/10.1002/1521-4184(200209)335:7<339::aid-ardp339>3.0.co
https://doi.org/10.1002/1521-4184(200209)335:7<339::aid-ardp339>3.0.co
Publikováno v:
Journal of Heterocyclic Chemistry. 38:435-441
Here in we describe our findings about the behaviour of some N-aryl- and N-heteroaryl-N'-alkylthioureas towards electrophilic reagents. In acid medium, the treatment of thioureas bearing aryl groups with 4-chloropyridine in 2-propanol yielded N-aryl-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6dbfcbd942b9cf8ccc80bb98ab3e846
https://doi.org/10.1002/jhet.5570380220
https://doi.org/10.1002/jhet.5570380220
Publikováno v:
Scopus-Elsevier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce06dc4de770be8f965a8f6d579ad682
https://doi.org/10.1055/s-2001-16768
https://doi.org/10.1055/s-2001-16768
Autor:
Josep E. Ban˜os, María Isabel Rodríguez-Franco, Concepción Pérez, Ana Martínez, Albert Badia, Isabel Dorronsoro
Publikováno v:
Archiv der Pharmazie. 333:118-122
The synthesis of new N-(4-pyridyl)-1-aminopyrazoles is described. Their binding properties were tested for muscarinic and other neurotransmitter receptors, together with their acetylcholinesterase inhibitory activity. The series derived from 3,5-dime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5be22c07a1a39f756c07cb390feb05ee
https://doi.org/10.1002/(sici)1521-4184(20005)333:5<118::aid-ardp118>3.0.co
https://doi.org/10.1002/(sici)1521-4184(20005)333:5<118::aid-ardp118>3.0.co