Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Isabel Castanho"'
Autor:
Kwangsik Nho, Shannon L. Risacher, Liana G. Apostolova, Paula J. Bice, Jared R. Brosch, Rachael Deardorff, Kelley Faber, Martin R. Farlow, Tatiana Foroud, Sujuan Gao, Thea Rosewood, Jun Pyo Kim, Kelly Nudelman, Meichen Yu, Paul Aisen, Reisa Sperling, Basavaraj Hooli, Sergey Shcherbinin, Diana Svaldi, Clifford R. Jack, William J. Jagust, Susan Landau, Aparna Vasanthakumar, Jeffrey F. Waring, Vincent Doré, Simon M. Laws, Colin L. Masters, Tenielle Porter, Christopher C. Rowe, Victor L. Villemagne, Logan Dumitrescu, Timothy J. Hohman, Julia B. Libby, Elizabeth Mormino, Rachel F. Buckley, Keith Johnson, Hyun-Sik Yang, Ronald C. Petersen, Vijay K. Ramanan, Nilüfer Ertekin-Taner, Prashanthi Vemuri, Ann D. Cohen, Kang-Hsien Fan, M. Ilyas Kamboh, Oscar L. Lopez, David A. Bennett, Muhammad Ali, Tammie Benzinger, Carlos Cruchaga, Diana Hobbs, Philip L. De Jager, Masashi Fujita, Vaishnavi Jadhav, Bruce T. Lamb, Andy P. Tsai, Isabel Castanho, Jonathan Mill, Michael W. Weiner, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI), the Department of Defense Alzheimer’s Disease Neuroimaging Initiative (DoD-ADNI), the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Study (A4 Study) and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN), the Australian Imaging, Biomarker & Lifestyle Study (AIBL), Andrew J. Saykin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Determining the genetic architecture of Alzheimer’s disease pathologies can enhance mechanistic understanding and inform precision medicine strategies. Here, we perform a genome-wide association study of cortical tau quantified by positron
Externí odkaz:
https://doaj.org/article/534dba93d5bf4620975ce9a0f564baf7
Autor:
Szi Kay Leung, Rosemary A. Bamford, Aaron R. Jeffries, Isabel Castanho, Barry Chioza, Christine S. Flaxman, Karen Moore, Emma L. Dempster, Joshua Harvey, Jonathan T. Brown, Zeshan Ahmed, Paul O’Neill, Sarah J. Richardson, Eilis Hannon, Jonathan Mill
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Increasing evidence suggests that alternative splicing plays an important role in Alzheimer’s disease (AD) pathology. We used long-read sequencing in combination with a novel bioinformatics tool (FICLE) to profile transcript diversity in t
Externí odkaz:
https://doaj.org/article/61f3ea0e8bfe4d4fbbcfd3346aaa8d89
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-16 (2021)
Abstract Background The combination of sodium bisulfite treatment with highly-parallel sequencing is a common method for quantifying DNA methylation across the genome. The power to detect between-group differences in DNA methylation using bisulfite-s
Externí odkaz:
https://doaj.org/article/edc75c961ca64a479ac03dcf4a9936b1
Autor:
Szi Kay Leung, Aaron R. Jeffries, Isabel Castanho, Ben T. Jordan, Karen Moore, Jonathan P. Davies, Emma L. Dempster, Nicholas J. Bray, Paul O’Neill, Elizabeth Tseng, Zeshan Ahmed, David A. Collier, Erin D. Jeffery, Shyam Prabhakar, Leonard Schalkwyk, Connor Jops, Michael J. Gandal, Gloria M. Sheynkman, Eilis Hannon, Jonathan Mill
Publikováno v:
Cell Reports, Vol 37, Iss 7, Pp 110022- (2021)
Summary: Alternative splicing is a post-transcriptional regulatory mechanism producing distinct mRNA molecules from a single pre-mRNA with a prominent role in the development and function of the central nervous system. We used long-read isoform seque
Externí odkaz:
https://doaj.org/article/1417caefb134428cac84fed4a4f86a78
Autor:
Luísa Santa-Marinha, Isabel Castanho, Rita Ribeiro Silva, Francisca Vaz Bravo, André Miguel Miranda, Torcato Meira, Rafaela Morais-Ribeiro, Fernanda Marques, Yimeng Xu, Kimberly Point du Jour, Markus Wenk, Robin Barry Chan, Gilbert Di Paolo, Vítor Pinto, Tiago Gil Oliveira
Publikováno v:
Cell Reports, Vol 30, Iss 12, Pp 4197-4208.e6 (2020)
Summary: Phosphatidic acid (PA) is a signaling lipid involved in the modulation of synaptic structure and functioning. Based on previous work showing a decreasing PA gradient along the longitudinal axis of the rodent hippocampus, we asked whether the
Externí odkaz:
https://doaj.org/article/f1f21573562f4a339d1161bbd04a7040
Autor:
Isabel Castanho, Tracey K. Murray, Eilis Hannon, Aaron Jeffries, Emma Walker, Emma Laing, Hedley Baulf, Joshua Harvey, Lauren Bradshaw, Andrew Randall, Karen Moore, Paul O’Neill, Katie Lunnon, David A. Collier, Zeshan Ahmed, Michael J. O’Neill, Jonathan Mill
Publikováno v:
Cell Reports, Vol 30, Iss 6, Pp 2040-2054.e5 (2020)
Summary: Alzheimer’s disease (AD) is associated with the intracellular aggregation of hyperphosphorylated tau and the accumulation of β-amyloid in the neocortex. We use transgenic mice harboring human tau (rTg4510) and amyloid precursor protein (J
Externí odkaz:
https://doaj.org/article/3cad2ca98a4f435e9d9d2b16cb529f93
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9d01797fbb6fe496835da0b64085468
https://doi.org/10.1002/alz.061296
https://doi.org/10.1002/alz.061296
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-16 (2021)
BMC Genomics
BMC Genomics
Background The combination of sodium bisulfite treatment with highly-parallel sequencing is a common method for quantifying DNA methylation across the genome. The power to detect between-group differences in DNA methylation using bisulfite-sequencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e9c8b6f7cc66ed75dd7593ae6b572d
https://doaj.org/article/edc75c961ca64a479ac03dcf4a9936b1
https://doaj.org/article/edc75c961ca64a479ac03dcf4a9936b1
Publikováno v:
Epigenetics insights. 15
Vertebrate and invertebrate models of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, have been paramount to our understanding of the pathophysiology of these conditions; however, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd87b94d9ebc18be9c9df8423f0a8204
https://pubmed.ncbi.nlm.nih.gov/36353727
https://pubmed.ncbi.nlm.nih.gov/36353727
Autor:
Aaron R. Jeffries, Jonathan Mill, Zeshan Ahmed, Tracey K. Murray, Szi Kay Leung, Eilis Hannon, Isabel Castanho, Katie Lunnon
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65e4a58aecb14353fe0237e22ff6c6ac
https://doi.org/10.1002/alz.045864
https://doi.org/10.1002/alz.045864