Deficiency of T-Cell Intracellular Antigen 1 in Murine Embryonic Fibroblasts Is Associated with Changes in Mitochondrial Morphology and Respiration

Autor: José M. Izquierdo, Beatriz Ramos Velasco, Isabel Carrascoso

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12775, p 12775 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
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International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12775

T-cell intracellular antigen 1 (TIA1) is a multifunctional RNA-binding protein involved in regulating gene expression and splicing during development and in response to environmental stress, to maintain cell homeostasis and promote survival. Herein,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae8c85a5c0871b0b6d8688b43230b80
http://europepmc.org/articles/PMC8657690

Transcriptome-wide analysis links the short-term expression of the b isoforms of TIA proteins to protective proteostasis-mediated cell quiescence response

Autor: Juan Carlos Oliveros, José M. Izquierdo, Daniel Tabas-Madrid, José Alcalde, Isabel Carrascoso

Publikováno v: PLoS ONE
PLoS ONE, Vol 13, Iss 12, p e0208526 (2018)
Digital.CSIC. Repositorio Institucional del CSIC
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Control of gene expression depends on genetics and environmental factors. The T-cell intracellular antigens T-cell intracellular antigen 1 (TIA1), TIA1-like/related protein (TIAL1/TIAR) and human antigen R (HuR/ELAVL1) are RNA-binding proteins that p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb1dee719491a209adac4c4f4215126
https://pubmed.ncbi.nlm.nih.gov/30533021

Ablation of the stress protease OMA1 protects against heart failure in mice

Autor: Maria del Mar Muñoz, Jesús Ruiz-Cabello, Rebeca Acín-Pérez, José M. Castellano, Carlos Torroja, Luis Jesús Jiménez-Borreguero, José Antonio Enríquez, Isabel Carrascoso, Carlos López-Otín, Pedro M. Quirós, Concepción Jiménez, Rocio Nieto-Arellano, Cristiane Benincá, Fátima Sánchez-Cabo, Ana Victoria Lechuga-Vieco, Andrés González-Guerra

Publikováno v: Science translational medicine. 10(434)

Heart failure (HF) is a major health and economic burden in developed countries. It has been proposed that the pathogenesis of HF may involve the action of mitochondria. We evaluate three different mouse models of HF: tachycardiomyopathy, HF with pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5058ae086be91ab6af3127956b34adaa
https://pubmed.ncbi.nlm.nih.gov/29593106

ROS-triggered phosphorylation of complex II by Fgr kinase regulates cellular adaptation to fuel use

Autor: Isabel Carrascoso, José Antonio Enríquez, María Mittelbrunn, Giovanni Manfredi, Patricio Fernández-Silva, Francisco Sánchez-Madrid, Marta Roche-Molina, Francesc Baixauli, Clifford A. Lowell, Rebeca Acín-Pérez, Ana Latorre-Pellicer, Acisclo Pérez-Martos

Publikováno v: Cell metabolism, vol 19, iss 6

SummaryElectron flux in the mitochondrial electron transport chain is determined by the superassembly of mitochondrial respiratory complexes. Different superassemblies are dedicated to receive electrons derived from NADH or FADH2, allowing cells to a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af0e0bfda7f9b0d6826b8d182fb04700
https://escholarship.org/uc/item/08w183p9

Knockdown of T-cell intracellular antigens triggers cell proliferation, invasion and tumor growth

Autor: Raquel Reyes, Isabel Carrascoso, José Alcalde, María Dolores Ludeña, José M. Izquierdo

Publikováno v: Biochemical Journal
Biochemical Journal, Portland Press, 2011, 435 (2), pp.337-344. ⟨10.1042/BJ20101030⟩

TIA (T-cell intracellular antigen) proteins function as DNA/RNA trans-acting regulators to expand transcriptome and proteome diversity in mammals. In the present paper we report that the stable silencing of TIA1 and/or TIAR/TIAL1 (TIA1-related/like p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::838908dc4b63832d094daa4bd0a8c1d8
https://hal.archives-ouvertes.fr/hal-00581531/file/PEER_stage2_10.1042%2FBJ20101030.pdf