Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Isabel Camino"'
Autor:
Simon R. Green, Susan H. Davis, Sebastian Damerow, Curtis A. Engelhart, Michael Mathieson, Beatriz Baragaña, David A. Robinson, Jevgenia Tamjar, Alice Dawson, Fabio K. Tamaki, Kirsteen I. Buchanan, John Post, Karen Dowers, Sharon M. Shepherd, Chimed Jansen, Fabio Zuccotto, Ian H. Gilbert, Ola Epemolu, Jennifer Riley, Laste Stojanovski, Maria Osuna-Cabello, Esther Pérez-Herrán, María José Rebollo, Laura Guijarro López, Patricia Casado Castro, Isabel Camino, Heather C. Kim, James M. Bean, Navid Nahiyaan, Kyu Y. Rhee, Qinglan Wang, Vee Y. Tan, Helena I. M. Boshoff, Paul J. Converse, Si-Yang Li, Yong S. Chang, Nader Fotouhi, Anna M. Upton, Eric L. Nuermberger, Dirk Schnappinger, Kevin D. Read, Lourdes Encinas, Robert H. Bates, Paul G. Wyatt, Laura A. T. Cleghorn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Tuberculosis is a major cause of mortality, and the rise of drug-resistant strains of Mycobacterium tuberculosis requires the urgent development of safe and effective treatments. In this work, the authors develop a compound against lysyl-tRNA synthet
Externí odkaz:
https://doaj.org/article/3aefb9dc25794e5b8cda7dfd998654ed
Akademický článek
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Autor:
Carine Sao Emani, Clement K. M. Tsui, Adama Bojang, Flavia Sorrentino, Yossef Av-Gay, María José Rebollo-López, Gagandeep Narula, Blanco Modesto J Remuinan, Eva Maria Lopez-Roman, Abraham L Moure, Beatriz Hernández Díaz, Esther Porras de Francisco, Patricia Casado Castro, Laura Guijarro López, Pedro Alfonso Torres-Gomez, Fátima Ortega, David Barros-Aguirre, Lluis Ballell, Isabel Camino
Publikováno v:
Journal of Medicinal Chemistry. 63:4732-4748
Screening of a GSK-proprietary library against intracellular Mycobacterium tuberculosis identified 1, a thioalkylbenzoxazole hit. Biological profiling and mutant analysis revealed that this compound is a prodrug that is bioactivated by the mycobacter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37597b28e01469f812a39e15644a876b
https://doi.org/10.1021/acs.jmedchem.0c00003
https://doi.org/10.1021/acs.jmedchem.0c00003
Autor:
Caroline Wilson, Peter Ray, Fabio Zuccotto, Jorge Hernandez, Anup Aggarwal, Claire Mackenzie, Nicola Caldwell, Malcolm Taylor, Margaret Huggett, Michael Mathieson, Dinakaran Murugesan, Alasdair Smith, Susan Davis, Mattia Cocco, Maloy K. Parai, Arjun Acharya, Fabio Tamaki, Paul Scullion, Ola Epemolu, Jennifer Riley, Laste Stojanovski, Eva Maria Lopez-Román, Pedro Alfonso Torres-Gómez, Ana Maria Toledo, Laura Guijarro-Lopez, Isabel Camino, Curtis A. Engelhart, Dirk Schnappinger, Lisa M. Massoudi, Anne Lenaerts, Gregory T. Robertson, Chris Walpole, David Matthews, David Floyd, James C. Sacchettini, Kevin D. Read, Lourdes Encinas, Robert H. Bates, Simon R. Green, Paul G. Wyatt
Publikováno v:
Journal of Medicinal Chemistry
With increasing drug resistance in tuberculosis (TB) patient populations, there is an urgent need for new drugs. Ideally, new agents should work through novel targets so that they are unencumbered by preexisting clinical resistance to current treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5566e8fcf104aad281ff69e40e769633
https://pubmed.ncbi.nlm.nih.gov/34910486
https://pubmed.ncbi.nlm.nih.gov/34910486
Autor:
Javier Alonso, Ángelo Gámez, Dejan Rasic, Milica Kontic, Vera Krstic, Vera Bunjevacki, Isabel Camino, Zoran Latkovic, Angel Pestaña, Iciar Palacios
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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The purpose of this work was to identify germ line RB1 mutations in 16 Serbian retinoblastoma patients for genetic counselling. Mutation analysis was carried out by PCR directed sequencing of the 27 exons. Loss of heterozygosity for two RB1 intrageni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::610a349f023d9f18ac70e9aa31e4e023
https://pubmed.ncbi.nlm.nih.gov/16972022
https://pubmed.ncbi.nlm.nih.gov/16972022
Autor:
Javier, Alonso, Itziar, Palacios, Angelo, Gámez, Isabel, Camino, Helena, Frayle, Ibis, Menéndez, Milica, Kontic, Purificación, García-Miguel, Ana, Sastre, José, Abelairas, Enric, Sarret, Constantino, Sabado, Aurora, Navajas, Mercé, Artigas, José M, Indiano, Ana, Carbone, Jordi, Rosell, Angel, Pestaña
Publikováno v:
Medicina clinica. 126(11)
Retinoblastoma, a prototype of hereditary cancer, is the most common intraocular tumor in children and a potential cause of blindness from therapeutic eye ablation, second tumors in germ line mutation carriers, and even death when untreated. The mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4decba66bec0ae69d6390b5bcce16022
https://pubmed.ncbi.nlm.nih.gov/16595085
https://pubmed.ncbi.nlm.nih.gov/16595085
Autor:
Enric Sarret, Isabel Camino, Constantino Sabado, Ángelo Gámez, José M. Indiano, Helena Frayle, Jordi Rosell, Mercé Artigas, Itziar Palacios, Javier Alonso, José Abelairas, Milica Kontic, Ana Carbone, Purificación García-Miguel, Ibis Menéndez, Ana Sastre, Aurora Navajas, Angel Pestaña
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
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[Fundamento y objetivo]: El retinoblastoma, prototipo de cáncer hereditario, puede causar ceguera, por enucleación terapéutica, segundos tumores en pacientes con mutación germinal e incluso muerte si no se trata. El diagnóstico molecular de 213
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90cb5d6d0539912d46d10aa83db0f604
http://hdl.handle.net/10261/81477
http://hdl.handle.net/10261/81477
Autor:
Angelo Gámez-Pozo, Isabel Camino, Itziar Palacios, Ibis Menéndez, José Abelairas, Angel Pestaña, Purificación García-Miguel, Javier Alonso, Milica Kontic
Publikováno v:
Human Mutation. 28:1245-1245
Precise identification of the pathogenic character of germline mutations in the retinoblastoma gene (RB1) is fundamental to provide genetic counselling to patients at risk of developing retinoblastoma. In contrast to bona fide oncogenic RB1 mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3034fe12b3cd25ce237e76d34dca0d41
https://doi.org/10.1002/humu.9512
https://doi.org/10.1002/humu.9512