Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Isabel C. Gonzalez"'
Autor:
Hua V Lin, Alexander M Efanov, Xiankang Fang, Lisa S Beavers, Xuesong Wang, Jingru Wang, Isabel C Gonzalez Valcarcel, Tianwei Ma
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157298 (2016)
GPR142, a putative amino acid receptor, is expressed in pancreatic islets and the gastrointestinal tract, but the ligand affinity and physiological role of this receptor remain obscure. In this study, we show that in addition to L-Tryptophan, GPR142
Externí odkaz:
https://doaj.org/article/6917374dbc7842d4acc4d2e702ee5f13
Autor:
Cristina Sayago, Nathan C. Fite, Juan J. Carrillo, Feiyu F. Zhang, Isabel C. Gonzalez Valcarcel, Howard B. Broughton, Alfonso Espada, Michael J. Chalmers, Yuewei Qian, Jeffrey Alan Dodge, Jorge Alsina-Fernandez, John Lee
Publikováno v:
ACS Medicinal Chemistry Letters. 9:912-916
[Image: see text] Molecular characterization of the binding epitope of IL-23R and its cognate cytokine IL-23 is paramount to understand the role in autoimmune diseases and to support the discovery of new inhibitors of this protein–protein interacti
Autor:
Martinez-Grau, Maria Angeles, Valcarcel, Isabel C. Gonzalez, Early, Julie V., Gessner, Richard Klaus, de Melo, Candice Soares, de la Nava, Eva Maria Martin, Korkegian, Aaron, Ovechkina, Yulia, Flint, Lindsay, Gravelle, Anisa, Cramer, Jeff W., Desai, Prashant V., Street, Leslie J., Odingo, Joshua, Masquelin, Thierry, Chibale, Kelly, Parish, Tanya
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 June 2018 28(10):1758-1764
Autor:
Jaclyn A. Barrett, Matthew R. Naylor, Maria-Jesus Blanco, R. Scott Lokey, Cameron R. Pye, Yongtong Lao, Isabel C. Gonzalez Valcarcel, Prashant V. Desai, Joshua Schwochert, Geri A. Sawada
Publikováno v:
ACS Medicinal Chemistry Letters. 7:757-761
Cyclic peptide (CP) natural products provide useful model systems for mapping "beyond-Rule-of-5" (bRo5) space. We identified the phepropeptins as natural product CPs with potential cell permeability. Synthesis of the phepropeptins and epimeric analog
Autor:
Mai A. Bailey, Maria Angeles Martinez-Grau, Yulia Ovechkina, Allen Casey, Tanya Parish, Isabel C. Gonzalez Valcarcel, Torey Alling, Juliane Ollinger, Michal Vieth, Megan Files, Julie V. Early
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:3608-3616
Mycobacterium tuberculosis is a global pathogen of huge importance which can adapt to several host niche environments in which carbon source availability is likely to vary. We developed and ran a phenotypic screen using butyrate as the sole carbon so
Autor:
Maria Angeles, Martinez-Grau, Isabel C Gonzalez, Valcarcel, Julie V, Early, Richard Klaus, Gessner, Candice Soares, de Melo, Eva Maria Martin, de la Nava, Aaron, Korkegian, Yulia, Ovechkina, Lindsay, Flint, Anisa, Gravelle, Jeff W, Cramer, Prashant V, Desai, Leslie J, Street, Joshua, Odingo, Thierry, Masquelin, Kelly, Chibale, Tanya, Parish
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Graphical abstract
Highlights • We conducted SAR for the aryl-oxadiazole series with anti-bacterial activity against Mycobacterium tuberculosis. • Improved compounds have sub-micromolar butyrate-specific activity. • Compounds are not cytot
Highlights • We conducted SAR for the aryl-oxadiazole series with anti-bacterial activity against Mycobacterium tuberculosis. • Improved compounds have sub-micromolar butyrate-specific activity. • Compounds are not cytot
Akademický článek
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Akademický článek
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Autor:
Joseph T. Brozinick, William Glen Holloway, Vincent L. Reynolds, Lisa A. Adams, David A Yurek, Jason Eric Lamar, Thomas B. Estridge, Thomas W. Seng, Isabel C. Gonzalez Valcarcel, Jennifer M. Weller, Marian Mosior, Eric D. Hawkins, Michael James Genin, Jeffrey Weidner
Publikováno v:
Journal of medicinal chemistry. 59(12)
To develop novel treatments for type 2 diabetes and dyslipidemia, we pursued inhibitors of serine palmitoyl transferase (SPT). To this end compounds 1 and 2 were developed as potent SPT inhibitors in vitro. 1 and 2 reduce plasma ceramides in rodents,
Autor:
Lisa Selsam Beavers, Tianwei Ma, Xiankang Fang, Isabel C. Gonzalez Valcarcel, Hua V. Lin, Xuesong Wang, Alexander M. Efanov, Jingru Wang
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 6, p e0157298 (2016)
PLoS ONE, Vol 11, Iss 6, p e0157298 (2016)
GPR142, a putative amino acid receptor, is expressed in pancreatic islets and the gastrointestinal tract, but the ligand affinity and physiological role of this receptor remain obscure. In this study, we show that in addition to L-Tryptophan, GPR142