Výsledky vyhledávání - "Isabel Burghardt"

Akademický článek

Negative allosteric modulators of metabotropic glutamate receptor 3 target the stem-like phenotype of glioblastoma

Autor: Hans-Georg Wirsching, Manuela Silginer, Elisa Ventura, Will Macnair, Isabel Burghardt, Manfred Claassen, Silvia Gatti, Jürgen Wichmann, Claus Riemer, Hannah Schneider, Michael Weller

Publikováno v: Molecular Therapy: Oncolytics, Vol 20, Iss , Pp 166-174 (2021)

Glioblastoma is an invariably deadly disease. A subpopulation of glioma stem-like cells (GSCs) drives tumor progression and treatment resistance. Two recent studies demonstrated that neurons form oncogenic glutamatergic electrochemical synapses with

Externí odkaz: https://doaj.org/article/5adacbaffe714cf49bafa9404a427847

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Akademický článek

Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization

Autor: Vadim Le Joncour, Pauliina Filppu, Maija Hyvönen, Minna Holopainen, S Pauliina Turunen, Harri Sihto, Isabel Burghardt, Heikki Joensuu, Olli Tynninen, Juha Jääskeläinen, Michael Weller, Kaisa Lehti, Reijo Käkelä, Pirjo Laakkonen

Publikováno v: EMBO Molecular Medicine, Vol 11, Iss 6, Pp 1-21 (2019)

Abstract The current clinical care of glioblastomas leaves behind invasive, radio‐ and chemo‐resistant cells. We recently identified mammary‐derived growth inhibitor (MDGI/FABP3) as a biomarker for invasive gliomas. Here, we demonstrate a novel

Externí odkaz: https://doaj.org/article/c1eac63859984fbf8aeb614cf57f36f3

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