Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Isabel Britsch"'
Autor:
Isabel Britsch, Anne P. van Wijngaarden, Xiurong Ke, Mark. A.J.M. Hendriks, Douwe F. Samplonius, Emily M. Ploeg, Wijnand Helfrich
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTTypically, anticancer CD8pos T cells occur at low frequencies and become increasingly impaired in the tumor micro environment. In contrast, antiviral CD8pos T cells display a much higher polyclonality, frequency, and functionality. In particu
Externí odkaz:
https://doaj.org/article/0d39d08c9dd24183a6b9857e3242983a
Autor:
Hao Zhang, Emily Maria Ploeg, Douwe Freerk Samplonius, Xiao Xiong, Xiurong Ke, Mark Alexander Johannes Martinus Hendriks, Isabel Britsch, Anne Paulien van Wijngaarden, Wijnand Helfrich
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 9 (2023)
Background CD73 is an ecto-enzyme that is involved in the conversion of pro-inflammatory extracellular ATP (eATP) excreted by cancer cells under stress to anti-inflammatory adenosine (ADO). A broad variety of solid cancer types was shown to exploit C
Externí odkaz:
https://doaj.org/article/6a3418819425477e9bac1effb2188d03
Autor:
Mark A.J.M. Hendriks, Isabel Britsch, Xiurong Ke, Anne P. van Wijngarden, Douwe F. Samplonius, Emily M. Ploeg, Wijnand Helfrich
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Cancer cells exploit CD47 overexpression to inhibit phagocytic elimination and neoantigen processing via the myeloid CD47-SIRPα axis and thereby indirectly evade adaptive T cell immunity. Here, we report on a hitherto unrecognized direct immunoinhib
Externí odkaz:
https://doaj.org/article/98669fa6874142af8bbb8031277bb690
Autor:
Mark A. J. M. Hendriks, Emily M. Ploeg, Iris Koopmans, Isabel Britsch, Xiurong Ke, Douwe F. Samplonius, Wijnand Helfrich
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Cancer cells overexpress CD47 to subvert phagocytic elimination and evade immunogenic processing of cancer antigens. Moreover, CD47 overexpression inhibits the antibody-dependent cellular phagocytosis (ADCP) and cytotoxicity (ADCC) activities of ther
Externí odkaz:
https://doaj.org/article/6ce893e0214243c392519ead7428b580