Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Isabel Beerman"'
Autor:
Hagai Yanai, Bongsoo Park, Hyunwook Koh, Hyo Jung Jang, Kelli L. Vaughan, Mayuri Tanaka-Yano, Miguel Aon, Madison Blanton, Ilhem Messaoudi, Alberto Diaz-Ruiz, Julie A. Mattison, Isabel Beerman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Dietary restriction has shown benefits in physiological, metabolic, and molecular signatures associated with aging but is a difficult lifestyle to maintain for most individuals. In mice, a less restrictive diet that allows for cyclical perio
Externí odkaz:
https://doaj.org/article/db9957647c4c41dba19b324fff38ec43
Autor:
Chen Chen, Bongsoo Park, Emeline Ragonnaud, Monica Bodogai, Xin Wang, Le Zong, Jung-Min Lee, Isabel Beerman, Arya Biragyn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The tumour microenvironment has been shown to change the phenotypes and functionality of immune cells to enable tumour propagation. Here authors show that cancers can derail B cell development to give rise to macrophage-like cells, contributing to ca
Externí odkaz:
https://doaj.org/article/1406e98d4c3841ff8d1d35bc0537f3f8
Publikováno v:
Frontiers in Aging, Vol 4 (2023)
The recently published article in Cell by the Sinclair lab and collaborators entitled “Loss of Epigenetic Information as a Cause of Mammalian Aging” [1] implicates heritable changes in gene expression as the basis for aging, a postulate consisten
Externí odkaz:
https://doaj.org/article/4254f34b0b214d7d8e833a4c707939e6
Autor:
Le Zong, Mayuri Tanaka-Yano, Bongsoo Park, Hagai Yanai, Ferda T. Turhan, Deborah L. Croteau, Jane Tian, Evandro F. Fang, Vilhelm A. Bohr, Isabel Beerman
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-9 (2021)
Abstract NAD+ supplementation has significant benefits in compromised settings, acting largely through improved mitochondrial function and DNA repair. Elevating NAD+ to physiological levels has been shown to improve the function of some adult stem ce
Externí odkaz:
https://doaj.org/article/ddf050c242524dbc83af057e4f93df30
Autor:
Hagai Yanai, Christopher Dunn, Bongsoo Park, Christopher Coletta, Ross A McDevitt, Taylor McNeely, Michael Leone, Robert P Wersto, Kathy A Perdue, Isabel Beerman
Publikováno v:
eLife, Vol 11 (2022)
Many age-associated changes in the human hematopoietic system have been reproduced in murine models; however, such changes have not been as robustly explored in rats despite the fact these larger rodents are more physiologically similar to humans. We
Externí odkaz:
https://doaj.org/article/59f23ad914a34093b52e8e4b94e793e7
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 8 (2022)
Increased age is blamed for a wide range of bone physiological changes, and although the underlying mechanisms affecting the decreased capacity for fracture healing are not fully understood, they are clearly linked to changes at the cellular level. R
Externí odkaz:
https://doaj.org/article/539fce5dd785445c9e060c6fd613b3bb
Autor:
Fernanda Gutierrez-Rodrigues, Isabel Beerman, Emma M. Groarke, Bhavisha A. Patel, Nina Spitofsky, Laura W. Dillon, Diego Quinones Raffo, Christopher S. Hourigan, Sachiko Kajigaya, Luigi Ferrucci, Neal S. Young
Publikováno v:
Haematologica, Vol 107, Iss 8 (2021)
Although cell-free DNA (cfDNA) tests have emerged as a potential non-invasive alternative to bone marrow biopsies for monitoring clonal hematopoiesis in hematologic diseases, whether commercial cfDNA assays can be implemented for the detection and qu
Externí odkaz:
https://doaj.org/article/d21f73a480b347d6bbef0f5a340c1989
Autor:
Valeria Lodde, Matteo Floris, Isabel Beerman, Rachel Munk, Rajan Guha, Maristella Steri, Valeria Orrù, Kotb Abdelmohsen, Peter D. Crompton, Myriam Gorospe, Maria Laura Idda, Francesco Cucca
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
We have previously shown that a variant of the TNFSF13B gene that we called BAFF-var increases the production of the cytokine BAFF, upregulating humoral immunity and increasing the risk for certain autoimmune diseases. In addition, genetic population
Externí odkaz:
https://doaj.org/article/256504d93815441c9879ffea37d2a21a
Autor:
Yingying Zhang, Jocelyn Charlton, Rahul Karnik, Isabel Beerman, Zachary D Smith, Hongcang Gu, Patrick Boyle, Xiaoli Mi, Kendell Clement, Ramona Pop, Andreas Gnirke, Derrick J Rossi, Alexander Meissner
Publikováno v:
eLife, Vol 7 (2018)
DNA methylation plays an essential role in mammalian genomes and expression of the responsible enzymes is tightly controlled. Deregulation of the de novo DNA methyltransferase DNMT3B is frequently observed across cancer types, yet little is known abo
Externí odkaz:
https://doaj.org/article/ec968c14f5da4542813e3bd8668faa0a
Autor:
Amanda J. Stock, Saipriya Ayyar, Amogh Kashyap, Yunong Wang, Hagai Yanai, Matthew F. Starost, Mayuri Tanaka-Yano, Monica Bodogai, Chongkui Sun, Yajun Wang, Yi Gong, Chandrakala Puligilla, Evandro F. Fang, Vilhelm A. Bohr, Yie Liu, Isabel Beerman
Publikováno v:
GeroScience.
Short telomeres are a defining feature of telomere biology disorders (TBDs), including dyskeratosis congenita (DC), for which there is no effective general cure. Patients with TBDs often experience bone marrow failure. NAD, an essential metabolic coe