Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Isabel A. Lefevre"'
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Akademický článek
Cerebrospinal fluid neurogranin in an inducible mouse model of neurodegeneration: A translatable marker of synaptic degeneration
Autor: Kina Höglund, Nathalie Schussler, Hlin Kvartsberg, Una Smailovic, Gunnar Brinkmalm, Victor Liman, Bruno Becker, Henrik Zetterberg, Angel Cedazo-Minguez, Shorena Janelidze, Isabel A. Lefevre, Stéphanie Eyquem, Oskar Hansson, Kaj Blennow
Publikováno v: Neurobiology of Disease, Vol 134, Iss , Pp - (2020)
Synapse impairment is thought to be an early event in Alzheimer's disease (AD); dysfunction and loss of synapses are linked to cognitive symptoms that precede neuronal loss and neurodegeneration. Neurogranin (Ng) is a somatodendritic protein that has
Externí odkaz: https://doaj.org/article/2a2166a0818947feb47ea5f79bda33ee
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4
Introduction to the EQIPD quality system
Autor: Lior Bikovski, Raafat Fares, Anton Bespalov, Claudia Kurreck, Leonardo Restivo, Paul Moser, Chantelle Ferland-Beckham, Claudia Stöger, Patricia Kabitzke, Ernesto Prado Montes de Oca, Bruce Altevogt, Valerie Gailus-Durner, Sabine M. Hölter, Piotr Popik, Martine C J Hofmann, Vootele Voikar, Lee Monk, Michael Schunn, Alexander Dityatev, Janko Samardzic, Gernot Riedel, Thomas Steckler, Natasja de Bruin, Merel Ritskes-Hoitinga, Kathleen Wuyts, Christoph H. Emmerich, Heidrun Potschka, Vincent Castagné, Christelle Froger-Colléaux, Fiona Ducrey, Anja Gilis, Björn Gerlach, Jan Vollert, Kimberley E. Wever, Sandrine Bongiovanni, Esmeralda Castaños-Vélez, Martien J H Kas, René Bernard, Malcolm R. Macleod, Isabel A Lefevre, Javier Guillén, Małgorzata Pietraszek, María Arroyo-Araujo, Ulrich Dirnagl
Publikováno v: Bespalov, A, Bernard, R, Gilis, A, Gerlach, B, Guillén, J, Castagné, V, Lefevre, I A, Ducrey, F, Monk, L, Bongiovanni, S, Altevogt, B, Arroyo-araujo, M, Bikovski, L, De Bruin, N, Castaños-vélez, E, Dityatev, A, Emmerich, C H, Fares, R, Ferland-beckham, C, Froger-colléaux, C, Gailus-durner, V, Hölter, S M, Hofmann, M C, Kabitzke, P, Kas, M J, Kurreck, C, Moser, P, Pietraszek, M, Popik, P, Potschka, H, Prado Montes De Oca, E, Restivo, L, Riedel, G, Ritskes-hoitinga, M, Samardzic, J, Schunn, M, Stöger, C, Voikar, V, Vollert, J, Wever, K E, Wuyts, K, Macleod, M R, Dirnagl, U & Steckler, T 2021, ' Introduction to the EQIPD quality system ', eLIFE, vol. 10 . https://doi.org/10.7554/eLife.63294
eLife, 10:e63294. ELIFE SCIENCES PUBLICATIONS LTD
eLife, Vol 10 (2021)
eLife 10, e63294 (2021). doi:10.7554/eLife.63294
eLife
Elife, 10
Bespalov, A, Bernard, R, Gilis, A, Gerlach, B, Guillén, J, Castagné, V, Lefevre, I A, Ducrey, F, Monk, L, Bongiovanni, S, Altevogt, B, Arroyo-Araujo, M, Bikovski, L, de Bruin, N, Castaños-Vélez, E, Dityatev, A, Emmerich, C H, Fares, R, Ferland-Beckham, C, Froger-Colléaux, C, Gailus-Durner, V, Hölter, S M, Hofmann, M C, Kabitzke, P, Kas, M J, Kurreck, C, Moser, P, Pietraszek, M, Popik, P, Potschka, H, Prado Montes de Oca, E, Restivo, L, Riedel, G, Ritskes-Hoitinga, M, Samardzic, J, Schunn, M, Stöger, C, Voikar, V, Vollert, J, Wever, K E, Wuyts, K, MacLeod, M R, Dirnagl, U & Steckler, T 2021, ' Introduction to the EQIPD quality system ', eLife, vol. 10, e63294 . https://doi.org/10.7554/eLife.63294
eLife, vol. 10, pp. e63294
While high risk of failure is an inherent part of developing innovative therapies, it can be reduced by adherence to evidence-based rigorous research practices. Numerous analyses conducted to date have clearly identified measures that need to be take
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aef7c0ead5b242adb59f95192215766
http://hdl.handle.net/10044/1/95909
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5
Systematic review of guidelines for internal validity in the design, conduct and analysis of preclinical biomedical experiments involving laboratory animals
Autor: Merel Ritskes-Hoitinga, Ulrich Dirnagl, Malcolm Macleod, Thomas Steckler, Jan Vollert, Esther Schenker, Anton Bespalov, Hanno Wuerbel, Heidrun Potschka, Kimberley E Wever, Bruce Altevogt, Andrew S C Rice, Judi Clark, Emily Sena, Bruno Boulanger, Gernot Riedel, Bettina Platt, Annesha Sil, Martien J Kas, Bernhard Voelkl, Mathias Jucker, Bettina M Wegenast-braun, René Bernard, Esmeralda Heiden, Ann-marie Waldron, Maarten Loos, Pim Drinkenburg, Juan Diego Pita almenar, David Gallacher, Anja Gilis, Greet Teuns, Karsten Wicke, Sabine Grote, Bernd Sommer, Janet Nicholson, Sanna Janhunen, Sami Virtanen, Kristin Cheng, Sylvie Ramboz, Emer Leahy, Isabel A Lefevre, Fiona Ducrey, Javier Guillen, Patri Vergara, Kimberley Wever, Martin Michel, Tom van de Casteele, Martin C Michel, Tom Van De Casteele, Henk Van Der Linde, Isabel Seiffert
Publikováno v: BMJ Open Science, Vol 4, Iss 1 (2020)
Over the last two decades, awareness of the negative repercussions of flaws in the planning, conduct and reporting of preclinical research involving experimental animals has been growing. Several initiatives have set out to increase transparency and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::f3c843a32daac53e6720e2c19b3ead99
https://openscience.bmj.com/content/4/1/e100046.full
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6
Introduction to the EQIPD Quality System
Autor: Anton Bespalov, Rene Bernard, Björn Gerlach, Christoph Emmerich, Malgorzata Pietraszek, Isabel Ann Lefevre, Esmeralda Castaños-Vélez, Alexander Dityatev, Patricia Kabitzke, Claudia Kurreck, Gernot Riedel, Jan Vollert, Kimberley Wever, Ulrich Dirnagl, Malcolm Macleod
While high risk of failure is an inherent part of developing innovative therapies, it can be reduced by adherence to evidence-based rigorous research practices. Numerous analyses conducted to date have clearly identified measures that need to be take
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df004194c1156caa3cba6d32b445b77b
https://doi.org/10.31219/osf.io/ng32b
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7
Learning from Principles of Evidence-Based Medicine to Optimize Nonclinical Research Practices
Autor: Rita J. Balice-Gordon, Isabel A. Lefevre
Publikováno v: Good Research Practice in Non-Clinical Pharmacology and Biomedicine
Handbook of Experimental Pharmacology
Handbook of Experimental Pharmacology-Good Research Practice in Non-Clinical Pharmacology and Biomedicine
Good Research Practice in Non-Clinical Pharmacology and Biomedicine ISBN: 9783030336554
Thousands of pharmacology experiments are performed each day, generating hundreds of drug discovery programs, scientific publications, grant submissions, and other efforts. Discussions of the low reproducibility and robustness of some of this researc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b53c8a0e3026aebc2ca5a3b017e5b5a6
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8
Learning from Principles of Evidence-Based Medicine to Optimize Nonclinical Research Practices
Autor: Isabel A, Lefevre, Rita J, Balice-Gordon
Publikováno v: Handbook of experimental pharmacology. 257
Thousands of pharmacology experiments are performed each day, generating hundreds of drug discovery programs, scientific publications, grant submissions, and other efforts. Discussions of the low reproducibility and robustness of some of this researc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9192f20188c40d2198e3566bdeb914d3
https://pubmed.ncbi.nlm.nih.gov/31529201
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9
Protocol for a systematic review of guidelines for rigour in the design, conduct and analysis of biomedical experiments involving laboratory animals
Autor: Thomas Steckler, Jan Vollert, Esther Schenker, Anton Bespalov, Hanno Wuerbel, Martin Christian Michel, Heidrun Potschka, Kimberley E Wever, Bruce Altevogt, Andrew S C Rice, Judi Clark, Bruno Boulanger, Gernot Riedel, Bettina Platt, Annesha Sil, Martien J Kas, Bernhard Voelkl, Mathias Jucker, Bettina M Wegenast-braun, René Bernard, Esmeralda Heiden, Ann-marie Waldron, Maarten Loos, Tom Van De casteele, Pim Drinkenburg, Juan Diego Pita almenar, David Gallacher, Henk Van Der linde, Anja Gilis, Greet Teuns, Karsten Wicke, Sabine Grote, Bernd Sommer, Janet Nicholson, Sanna Janhunen, Sami Virtanen, Kristin Cheng, Sylvie Ramboz, Emer Leahy, Isabel A Lefevre, Fiona Ducrey, Javier Guillen, Patri Vergara, Thomas Ingraham
Publikováno v: BMJ Open Science
BMJ Open Science, Vol 2, Iss 1 (2018)
Vollert, J, Schenker, E, Macleod, M, Bespalov, A, Wuerbel, H, Michel, M C, Dirnagl, U, Potschka, H, Wever, K E, Steckler, T, Altevogt, B & Rice, A S C 2018, ' Protocol for a systematic review of guidelines for rigour in the design, conduct and analysis of biomedical experiments involving laboratory animals ', BMJ Open Science, vol. 2, no. 1, pp. e000004 . https://doi.org/10.1136/bmjos-2018-000004
Vollert, Jan; Schenker, Esther; Macleod, Malcolm; Bespalov, Anton; Würbel, Hanno; Michel, Martin Christian; Dirnagl, Ulrich; Potschka, Heidrun; Wever, Kimberley E; Steckler, Thomas; Altevogt, Bruce; Rice, Andrew S C (2018). Protocol for a systematic review of guidelines for rigour in the design, conduct and analysis of biomedical experiments involving laboratory animals. BMJ open science, 2(1), e000004. BMJ Publishing Group 10.1136/bmjos-2018-000004
Objective Within the last years, there has been growing awareness of the negative repercussions of unstandardized planning, conduct and reporting of preclinical and biomedical research. Several initiatives have set the aim of increasing validity and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45451d537d3977c8a94faa520489db09
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10
Functional Studies of Sodium Channels: From Target to Compound Identification
Autor: Thomas Licher, Daniel Bertrand, Jean-Marie Chambard, Isabel A. Lefevre, Bruno Biton, Michel Partiseti, Christophe Lanneau
Publikováno v: Current Protocols in Pharmacology
Over the last six decades, voltage-gated sodium (Nav ) channels have attracted a great deal of scientific and pharmaceutical interest, driving fundamental advances in both biology and technology. The structure and physiological function of these chan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915596759b76970215116367c9696128
https://doi.org/10.1002/cpph.14
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