Minor alterations in the intestinal microbiota composition upon Rotavirus infection do not affect susceptibility to DSS colitis

Autor: Kedir Hussen Hamza, Emma Dunér, Isabel Ulmert, Armando Arias, Daniel Sorobetea, Katharina Lahl

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract Viral triggers at the intestinal mucosa can have multiple global effects on intestinal integrity, causing elevated intestinal barrier strength and relative protection from subsequent inflammatory bowel disease (IBD) induction in various mode

Externí odkaz: https://doaj.org/article/5f477c0aee734c6986fc32b1f6080948

Loss of Bcl6 transcriptionally alters classical dendritic cells and diminishes T follicular helper cell and Th17-inducing cDC2 in mice

Autor: Hongkui Xiao, Isabel Ulmert, Johanna Huber, Hamsa Narasimhan, Luisa Bach, Ilia Kurochkin, Urs Mörbe, Lili Zhang, Andreas Schlitzer, Filipe Pereira, Barbara U. Schraml, Dirk Baumjohann, Katharina Lahl

Conventional dendritic cells (cDC) play key roles in immune induction, but what drives their heterogeneity and functional specialization is still ill-defined. Here we show that deletion of the transcriptional repressor Bcl6 in murine cDC alters the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::872b82dc5c79377fe90f831cd69313fb
https://doi.org/10.1101/2022.08.10.503322

αvβ8 integrin-expression by BATF3-dependent dendritic cells facilitates early IgA responses to Rotavirus

Autor: Bernard Malissen, Joy Nakawesi, Julia Hütter, Sébastien This, Harry B. Greenberg, L. J. Gooday, A. Garcias López, V. Barateau, Katharina Lahl, K. Getachew Muleta, K. Fog Thomsen, Olivier Thaunat, M. Boucard-Jourdin, T. Defrance, Didier Poncet, Isabel Ulmert, H. Paidassi

Publikováno v: Mucosal Immunology
Mucosal Immunology, Nature Pub. Group, 2020, ⟨10.1038/s41385-020-0276-8⟩
Mucosal Immunology, 2021, ⟨10.1038/s41385-020-0276-8⟩
Mucosal Immunology, 2020, ⟨10.1038/s41385-020-0276-8⟩

International audience; Secretory intestinal IgA can protect from re-infection with rotavirus (RV), but very little is known about the mechanisms that induce IgA production during intestinal virus infections. Classical dendritic cells (cDCs) in the i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b1ee3356c089daea15daecb26a2cccc
https://doi.org/10.1038/s41385-020-0276-8

Minor alterations in the intestinal microbiota composition upon Rotavirus infection do not affect susceptibility to DSS colitis

Autor: Katharina Lahl, Isabel Ulmert, Armando Arias, Kedir Hussen Hamza, Emma Dunér, Daniel Sorobetea

Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Hamza, K H, Duner, E, Ulmert, I, Arias, A, Sorobetea, D & Lahl, K 2021, ' Minor alterations in the intestinal microbiota composition upon Rotavirus infection do not affect susceptibility to DSS colitis ', Scientific Reports, vol. 11, no. 1, 13485 . https://doi.org/10.1038/s41598-021-92796-7

Viral triggers at the intestinal mucosa can have multiple global effects on intestinal integrity, causing elevated intestinal barrier strength and relative protection from subsequent inflammatory bowel disease (IBD) induction in various models. As vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c22e359c51a6367d5d09985c95e246f
https://pubmed.ncbi.nlm.nih.gov/34188111

Migration of intestinal dendritic cell subsets upon intrinsic and extrinsic TLR3 stimulation

Autor: Agnès Garcias López, Isabel Ulmert, Julia Hütter, Katarzyna Müller Luda, Vasileios Bekiaris, Bernhard Holzmann, Joy Nakawesi, Bernard Malissen, Katharina Lahl, William W. Agace, Konjit Getachew Muleta, Meredith O'Keeffe, Knut Kotarsky

Initiation of adaptive immunity to particulate antigens in lymph nodes largely depends on their presentation by migratory dendritic cells (DCs). DC subsets differ in their capacity to induce specific types of immunity, allowing subset-specific DC-tar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a685b588134d098cba88c1fbb10af67a
https://doi.org/10.1101/785675