High frequency of antidrug antibodies and association of random drug levels with efficacy in certolizumab pegol-treated patients with rheumatoid arthritis: results from the BRAGGSS cohort

Autor: Jani, M, Isaacs, JD, Morgan, AW, Wilson, AG, D, Plant., Hyrich, KL, Chinoy, H, Barton, A, Braggss

Publikováno v: Annals of the rheumatic diseases
Annals of the Rheumatic Diseases

Objectives To evaluate (i) the association between random certolizumab drug levels, antidrug antibodies (ADAbs) and treatment response in patients with rheumatoid arthritis (RA); (ii) longitudinal factors associated with ADAbs and certolizumab drug l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3a0c287d2215fc3d9840efacb553f62a
https://doi.org/10.1136/annrheumdis-2015-208849

Symptom-based stratification of patients with primary Sjögren's syndrome: multi-dimensional characterisation of international observational cohorts and reanalyses of randomised clinical trials

Autor: Tarn, JR, Howard-Tripp, N, Lendrem, DW, Mariette, X, Saraux, A, Devauchelle-Pensec, V, Seror, R, Skelton, AJ, James, K, McMeekin, P, Al-Ali, S, Hackett, KL, Lendrem, BC, Hargreaves, B, Casement, J, Mitchell, S, Bowman, SJ, Price, E, Pease, CT, Emery, P, Lanyon, P, Hunter, J, Gupta, M, Bombardieri, M, Sutcliffe, N, Pitzalis, C, McLaren, J, Cooper, A, Regan, M, Giles, I, Isenberg, D, Saravanan, V, Coady, D, Dasgupta, B, McHugh, N, Young-Min, S, Moots, R, Gendi, N, Akil, M, Griffiths, B, Johnsen, SJA, Norheim, KB, Omdal, R, Stocken, D, Everett, C, Fernandez, C, Isaacs, JD, Gottenberg, J-E, Ng, W-F, French ASSESS cohort, UK Primary Sjögren's Syndrome Registry

Background Heterogeneity is a major obstacle to developing effective treatments for patients with primary Sjögren's syndrome. We aimed to develop a robust method for stratification, exploiting heterogeneity in patient-reported symptoms, and to relat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::97af6517ec3a0615b03cf0791fda16ea

A unifying theory for cognitive abnormalities in functional neurological disorders, fibromyalgia and chronic fatigue syndrome: systematic review

Autor: Teodoro, T, Edwards, MJ, Isaacs, JD

BACKGROUND: Functional cognitive disorder (FCD) describes cognitive dysfunction in the absence of an organic cause. It is increasingly prevalent in healthcare settings yet its key neuropsychological features have not been reported in large patient co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::210e17b7b8a2b1f05d0a965da79bf0e1
https://openaccess.sgul.ac.uk/id/eprint/109850/1/jnnp-2017-317823.full.pdf

The RA-MAP Consortium: a working model for academia-industry collaboration

Autor: Cope, AP, Barnes, MR, Belson, A, Binks, M, Brockbank, S, Bonachela-Capdevila, F, Carini, C, Fisher, BA, Goodyear, CS, Emery, P, Ehrenstein, MR, Gozzard, N, Harris, R, Hollis, S, Keidel, S, Levesque, M, Lindholm, C, McDermott, MF, McInnes, IB, Mela, CM, Parker, G, Read, S, Pedersen, AW, Ponchel, F, Porter, D, Rao, R, Rowe, A, Schulz-Knappe, P, Sleeman, MA, Symmons, D, Taylor, PC, Tom, B, Tsuji, W, Verbeeck, D, Isaacs, JD, Consortium, Ra-Map

Publikováno v: The RA-MAP Consortium, Symmons, D & Sergeant, J 2017, ' The RA-MAP Consortium: a working model for academic-industry collaboration ', Nature Reviews Rheumatology, vol. 14, pp. 53-60 . https://doi.org/10.1038/nrrheum.2017.200

Collaboration can be challenging; nevertheless, the emerging successes of large, multi-partner, multi-national cooperatives and research networks in the biomedical sector have sustained the appetite of academics and industry partners for developing a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa80a6a87b81a291405f8290bdbc81e

Brain pseudotumour secondary to Behçet's disease.

Autor: Mousa, AE, Okasha, M, Isaacs, JD, Price, DA, Bhatnagar, P, Joshi, A, Surash, S

Publikováno v: Annals of the Royal College of Surgeons of England; 2019, Vol. 101 Issue 8, pe164-e168, 5p