Hsp90 as a Gatekeeper of Tumor Angiogenesis: Clinical Promise and Potential Pitfalls

Autor: Bohonowych, J. E., Gopal, U., Isaacs, J. S.

Publikováno v: Journal of Oncology.

Tumor vascularization is an essential modulator of early tumor growth, progression, and therapeutic outcome. Although antiangiogenic treatments appear promising, intrinsic and acquired tumor resistance contributes to treatment failure. Clinical inhib

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Requirement for HDM2 activity in the rapid degradation of p53 in neuroblastoma.

Autor: Isaacs JS; Tumor Cell Biology Section, Medicine Branch, NCI, National Institutes of Health, Rockville, Maryland 20850, USA., Saito S, Neckers LM

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2001 May 25; Vol. 276 (21), pp. 18497-506. Date of Electronic Publication: 2001 Feb 26.

Interference of proteins involved in the cytoplasmic sequestration of p53 with human papillomavirus E6-mediated degradation.

Autor: Isaacs JS; UNC Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, 27599, USA., Barrett JC, Weissman BE

Publikováno v: Molecular carcinogenesis [Mol Carcinog] 1999 Jan; Vol. 24 (1), pp. 70-7.

p53-dependent p21 induction following gamma-irradiation without concomitant p53 induction in a human peripheral neuroepithelioma cell line.

Autor: Isaacs JS; Department of Biochemistry and Biophysics and the University of North Carolina-Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599, USA., Chiao C, Merrick BA, Selkirk JK, Barrett JC, Weissman BE

Publikováno v: Cancer research [Cancer Res] 1997 Jul 15; Vol. 57 (14), pp. 2986-92.