Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Isaac Zentner"'
Autor:
Alyssa Mezochow, Kiran T. Thakur, Isaac Zentner, Selvakumar Subbian, Leonid Kagan, Christopher Vinnard
Publikováno v:
International Journal of Infectious Diseases, Vol 84, Iss , Pp 15-21 (2019)
Objective: There is considerable uncertainty regarding the optimal use of rifampicin for the treatment of tuberculous (TB) meningitis. A pharmacokinetic modeling and simulation study of rifampicin concentrations in cerebrospinal fluid (CSF) during TB
Externí odkaz:
https://doaj.org/article/bb305d948e024f5397afea4dfded2e40
Autor:
Isaac Zentner, Hyun-moon Back, Leonid Kagan, Selvakumar Subbian, Jyothi Nagajyothi, Shashikant Srivastava, Jotam Pasipanodya, Tawanda Gumbo, Gregory P. Bisson, Christopher Vinnard
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
BackgroundThe potential for hepatotoxicity during isoniazid-based tuberculosis (TB) treatment presents a major challenge for TB control programs worldwide. We sought to determine whether pharmacokinetic exposures of isoniazid and its metabolites were
Externí odkaz:
https://doaj.org/article/88c5b1cb32684316808494ef3e6882d1
Autor:
Isaac Zentner, Chawangwa Modongo, Nicola M. Zetola, Jotam G. Pasipanodya, Shashikant Srivastava, Scott K. Heysell, Stellah Mpagama, Hans P. Schlect, Tawanda Gumbo, Gregory P. Bisson, Christopher Vinnard
Publikováno v:
International Journal of Infectious Diseases, Vol 68, Iss , Pp 18-23 (2018)
Objectives: Pyrazinamide is a key drug in the first-line treatment regimen for tuberculosis, with a potent sterilizing effect. Although low pyrazinamide peak serum concentrations (Cmax) are associated with poor treatment outcomes, many resource-const
Externí odkaz:
https://doaj.org/article/da7f0f48aca64586815f2625611c01a0
Autor:
Christopher Vinnard, Isabel Manley, Brittney Scott, Mariana Bernui, Joella Adams, Sheryl Varghese, Isaac Zentner, Michele A. Kutzler
Publikováno v:
Tuberculosis Research and Treatment, Vol 2017 (2017)
Background. Rifampin malabsorption is frequently observed in tuberculosis patients coinfected with human immunodeficiency virus (HIV) but cannot be predicted by patient factors such as CD4+ T cell count or HIV viral load. Methods. We sought to descri
Externí odkaz:
https://doaj.org/article/69a8158ccad64e999e370a2c56479ad6
Autor:
Museveni Justine, Mohammad H. Al-Shaer, Tania A Thomas, Charles A. Peloquin, Sarah Criddle, Christopher Vinnard, Stellah G. Mpagama, Estomih Mduma, Scott K. Heysell, Daniel Van Aartsen, Isaac Zentner, Prakruti Rao, Claire Szipszky
Publikováno v:
J Pediatric Infect Dis Soc
Background Individual pharmacokinetic variability is a driver of poor tuberculosis (TB) treatment outcomes. We developed a method for measurement of rifampin concentrations by urine colorimetry and a mobile phone photographic application to predict c
Autor:
Kiran T. Thakur, Christopher Vinnard, Leonid Kagan, Isaac Zentner, Selvakumar Subbian, Alyssa Mezochow
Publikováno v:
International Journal of Infectious Diseases, Vol 84, Iss, Pp 15-21 (2019)
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Objective: There is considerable uncertainty regarding the optimal use of rifampicin for the treatment of tuberculous (TB) meningitis. A pharmacokinetic modeling and simulation study of rifampicin concentrations in cerebrospinal fluid (CSF) during TB
Autor:
Tawanda Gumbo, Shashikant Srivastava, Hyun-moon Back, Christopher Vinnard, Jyothi F. Nagajyothi, Leonid Kagan, Jotam G. Pasipanodya, Gregory P. Bisson, Isaac Zentner, Selvakumar Subbian
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Frontiers in Pharmacology
Frontiers in Pharmacology
Background: The potential for hepatotoxicity during isoniazid-based tuberculosis (TB) treatment presents a major challenge for TB control programs worldwide. We sought to determine whether pharmacokinetic exposures of isoniazid and its metabolites we
Autor:
Gregory P. Bisson, Isaac Zentner, Srivastava S, Jyothi F. Nagajyothi, Leonid Kagan, Hyun-moon Back, Selvakumar Subbian, Pasipanodya J, Gumbo T, Christopher Vinnard
BackgroundThe potential for hepatotoxicity during isoniazid-based tuberculosis (TB) treatment presents a major challenge for TB control programs worldwide. We sought to determine whether pharmacokinetic exposures of isoniazid and its metabolites were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31aad285e5ca706699696e33cb4d429
https://doi.org/10.1101/2020.04.14.20065292
https://doi.org/10.1101/2020.04.14.20065292
Autor:
Stellah G. Mpagama, Tawanda Gumbo, Christopher Vinnard, Jotam G. Pasipanodya, Chawangwa Modongo, Nicola M. Zetola, Gregory P. Bisson, Scott K. Heysell, Shashikant Srivastava, Hans P. Schlect, Isaac Zentner
Publikováno v:
International Journal of Infectious Diseases, Vol 68, Iss, Pp 18-23 (2018)
Objectives: Pyrazinamide is a key drug in the first-line treatment regimen for tuberculosis, with a potent sterilizing effect. Although low pyrazinamide peak serum concentrations (Cmax) are associated with poor treatment outcomes, many resource-const
Autor:
Isaac Zentner, Sharon H. Anderson, Carol Lackman-Smith, Beth A. Snyder, Suhman Chung, Yvonne M. Mueller, Karissa Lozenski, Aidan S Hancock, Irwin Chaiken, Stuart F. J. LeGrice, Deena Ratner, Alina C. Boesteanu, Phalguni Gupta, Marie K. Mankowski, Jennifer L. Hope, Natalie M. Jones, Joseph A. Fraietta, Brian Wigdahl, Peter D. Katsikis
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:7056-7071
In the absence of universally available antiretroviral (ARV) drugs or a vaccine against HIV-1, microbicides may offer the most immediate hope for controlling the AIDS pandemic. The most advanced and clinically effective microbicides are based on ARV