Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Isaac Woodhouse"'
Autor:
Estelle Marrer-Berger, Annalisa Nicastri, Angelique Augustin, Vesna Kramar, Hanqing Liao, Lydia Jasmin Hanisch, Alejandro Carpy, Tina Weinzierl, Evelyne Durr, Nathalie Schaub, Ramona Nudischer, Daniela Ortiz-Franyuti, Ekaterina Breous-Nystrom, Janick Stucki, Nina Hobi, Giulia Raggi, Lauriane Cabon, Emmanuelle Lezan, Pablo Umaña, Isaac Woodhouse, Alexander Bujotzek, Christian Klein, Nicola Ternette
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Selective binding of TCR-like antibodies that target a single tumour-specific peptide antigen presented by human leukocyte antigens (HLA) is the absolute prerequisite for their therapeutic suitability and patient safety. To date, selectivity
Externí odkaz:
https://doaj.org/article/1e7a4a6f3006436c814053de1558d191
Autor:
Hanqing Liao, Carolina Barra, Zhicheng Zhou, Xu Peng, Isaac Woodhouse, Arun Tailor, Robert Parker, Alexia Carré, Persephone Borrow, Michael J. Hogan, Wayne Paes, Laurence C. Eisenlohr, Roberto Mallone, Morten Nielsen, Nicola Ternette
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Understanding the nature and extent of non-canonical human leukocyte antigen (HLA) presentation in tumour cells is a priority for target antigen discovery for the development of next generation immunotherapies in cancer. We here employ a de
Externí odkaz:
https://doaj.org/article/cf8a21489fa4434197893cf308fd3b24
Autor:
Xu Peng, Isaac Woodhouse, Gemma Hancock, Robert Parker, Kristina Marx, Julius Müller, Silvia Salatino, Thomas Partridge, Annalisa Nicastri, Hanqing Liao, Gary Kruppa, Karin Hellner, Lucy Dorrell, Nicola Ternette
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106101- (2023)
Summary: Current immunotherapeutic approaches for human papillomavirus (HPV)-driven cervical cancer target the viral oncogenes E6 and E7. We report viral canonical and alternative reading frame (ARF)-derived sequences presented on cervical tumor cell
Externí odkaz:
https://doaj.org/article/7a2d88fc08a94b27b6d93df3c7c3919a
Autor:
Andrew Kam Ho Wong, Isaac Woodhouse, Frank Schneider, Deanna A. Kulpa, Guido Silvestri, Cheryl L. Maier
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 6, Pp 100321- (2021)
Summary: The pathogenesis of severe coronavirus disease 2019 (COVID-19) remains poorly understood. While several studies suggest that immune dysregulation plays a central role, the key mediators of this process are yet to be defined. Here, we demonst
Externí odkaz:
https://doaj.org/article/743f4b2bc42b43afa89942e1a244d4ab
Autor:
Hanqing Liao, Carolina Barra, Xu Peng, Isaac Woodhouse, Arun Tailor, Robert Parker, Alexia Carré, Roberto Mallone, Michael Hogan, Wayne Paes, Laurence Eisenlohr, Morten Nielsen, Nicola Ternette
Cryptic Human Leukocyte Antigen (HLA)-presented peptide identification from unannotated genome sources is a priority for target antigen discovery for development of next generation immunotherapies in cancer. Current immunopeptidomic approaches utiliz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d298bd98c9920aca522dc080e45198fc
https://doi.org/10.21203/rs.3.rs-1890352/v1
https://doi.org/10.21203/rs.3.rs-1890352/v1
Autor:
Estelle Marrer-Berger, Annalisa Nicastri, Angelique Augustin, Vesna Pulko, Hanqing Liao, Lydia Duerner, Tina Wienzierl, Lauriane Cabon, Emmanuelle Lezan, Christian Klein, Pablo Umaña, Isaac Woodhouse, Alexander Bujotzek, Nicola Ternette
Selective binding of TCR-based therapies that target a single tumour-specific peptide epitope presented by human leukocyte antigens (HLA) is the absolute prerequisite for their therapeutic suitability and patient safety. To date, selectivity assessme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e04b19e31af2a9eb4c1c1a8936b2307a
https://doi.org/10.21203/rs.3.rs-1828302/v1
https://doi.org/10.21203/rs.3.rs-1828302/v1
Autor:
Ruichong Ma, Margarida Rei, Isaac Woodhouse, Katherine Ferris, Sophie Kirschner, Anandhakumar Chandran, Uzi Gileadi, Ji-Li Chen, Mariana Pereira Pinho, Yoanna Ariosa-Morejon, Skirmantas Kriaucionis, Nicola Ternette, Hashem Koohy, Olaf Ansorge, Graham Ogg, Puneet Plaha, Vincenzo Cerundolo
Publikováno v:
Neuro-oncology. 24(12)
Background Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults. Despite maximal treatment, median survival remains dismal at 14–24 months. Immunotherapies, such as checkpoint inhibition, have revolutionized management
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd2e83d5b95efd2a94b8aa3c6564b90
https://pubmed.ncbi.nlm.nih.gov/35468205
https://pubmed.ncbi.nlm.nih.gov/35468205
Autor:
Paul R Buckley, Chloe H Lee, Ruichong Ma, Isaac Woodhouse, Jeongmin Woo, Vasily O Tsvetkov, Dmitrii S Shcherbinin, Agne Antanaviciute, Mikhail Shughay, Margarida Rei, Alison Simmons, Hashem Koohy
Publikováno v:
Briefings in Bioinformatics. 23
T cell recognition of a cognate peptide–major histocompatibility complex (pMHC) presented on the surface of infected or malignant cells is of the utmost importance for mediating robust and long-term immune responses. Accurate predictions of cognate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af5f3c17e0341cfac81875e305b07c99
https://doi.org/10.1093/bib/bbac141
https://doi.org/10.1093/bib/bbac141
Autor:
Arun Tailor, Hala Estephan, Robert Parker, Isaac Woodhouse, Majd Abdulghani, Annalisa Nicastri, Keaton Jones, Silvia Salatino, Ruth Muschel, Timothy Humphrey, Amato Giaccia, Nicola Ternette
Publikováno v:
Molecularcellular proteomics : MCP. 21(11)
Little is known about the pathways regulating MHC antigen presentation and the identity of treatment-specific T cell antigens induced by ionizing radiation. For this reason, we investigated the radiation-specific changes in the colorectal tumor cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::730647978972e2d341afdf27ea21294a
https://pubmed.ncbi.nlm.nih.gov/36089194
https://pubmed.ncbi.nlm.nih.gov/36089194
Autor:
Wayne Paes, Andrew Leishman, Kate Anderton, Hanqing Liao, Isaac Woodhouse, Robert Parker, Annalisa Nicastri, Peter Joyce, Nicola Ternette
Publikováno v:
Cancer Research. 82:4153-4153
The antigen processing machinery of a cell shapes the repertoire of peptides presented for immune recognition on the cell surface. Human leukocyte antigen class I (HLA-I) molecules present peptides that are recognised by both CD8+ T cells and NK cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b085bc4eac172ffd935479ac782283b
https://doi.org/10.1158/1538-7445.am2022-4153
https://doi.org/10.1158/1538-7445.am2022-4153