Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Isaac W. Haynes"'
Autor:
Sean P. Martinson, Jenna R. Garcia, Isaac W. Haynes, Simrun P. Saini, Elisan R. Wagner, Grace R. Long, Charles M. Folden III, Sunil S. Chirayath
Publikováno v:
SSRN Electronic Journal.
Publikováno v:
Analytical Chemistry. 91:13439-13447
Macrocycles provide intricate shape manifolds that leverage the depth of the modern organic chemistry toolbox. Novel chemistry can be introduced via new bond types and unique torsional angles inaccessible by traditional small molecules and biomolecul
Autor:
Amber L H, Gray, Carlos A, Steren, Isaac W, Haynes, Guillermo A, Bermejo, Filippo, Favretto, Markus, Zweckstetter, Thanh D, Do
Publikováno v:
The journal of physical chemistry. B. 125(5)
Falling outside of Lipinski's rule of five, macrocyclic drugs have accessed unique binding sites of their target receptors unreachable by traditional small molecules. Cyclosporin(e) A (CycA), an extensively studied macrocyclic natural product, is an
Autor:
Filippo Favretto, Markus Zweckstetter, Isaac W. Haynes, Carlos A. Steren, Guillermo A. Bermejo, Thanh D. Do, Amber L. H. Gray
Publikováno v:
The journal of physical chemistry / B 125(5), 1378-1391 (2021). doi:10.1021/acs.jpcb.0c11152
Falling outside of Lipinski's rule of five, macrocyclic drugs have accessed unique binding sites of their target receptors unreachable by traditional small molecules. Cyclosporin(e) A (CycA), an extensively studied macrocyclic natural product, is an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::752de8a345657c0f46c282f3b36a2f75