Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Isaac Veinbergs"'
Autor:
Bradford Casey, Rose B. Creed, Matthew S. Goldberg, Liliana Menalled, Holden B. Janssens, Isaac Veinbergs, Kuldip D. Dave, Marieke van der Hart, Arash Rassoulpour
Publikováno v:
Neuroscience. 409
Parkinson's disease (PD) is the most common neurodegenerative movement disorder and is characterized by the loss of neurons in the substantia nigra that project to the striatum and release dopamine (DA), which is required for normal movement. Common
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50aec969860cef7ab4c9794e522a1d9e
https://pubmed.ncbi.nlm.nih.gov/31029729
https://pubmed.ncbi.nlm.nih.gov/31029729
Publikováno v:
Behavioral Neuroscience. 122:570-575
AC-260584 (4-[3-(4-butylpiperidin-1-yl)-propyl]-7-fluoro-4H-benzo[1,4]oxazin-3-one) is a potent and selective muscarinic M-sub-1 receptor agonist. AC-260584 was evaluated in animal models: antipsychotic-like effects were tested by the ability to redu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c58398bdc460f72a6bf17f84c988f5a
https://doi.org/10.1037/0735-7044.122.3.570
https://doi.org/10.1037/0735-7044.122.3.570
Autor:
Scott C. Harvey, Isaac Veinbergs, Kimberly E. Vanover, Carl-Magnus A. Andersson, Allan K. Uldam, David M. Weiner, Fabrice Piu, Bo-Ragner Tolf, Andria L. Del Tredici, Mark A. Geyer, Thomas Son, Robert E. Davis, Malath Makhay, Thomas R. Ott, Mark R. Brann, Jelveh Lameh, Ethan S. Burstein, Nathalie Schlienger, Hans H. Schiffer, Susan B. Powell, Luis R. Gardell, Mikkel B. Thygesen
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 317:910-918
The in vitro and in vivo pharmacological properties of N -(4-fluorophenylmethyl)- N -(1-methylpiperidin-4-yl)- N ′-(4-(2-methylpropyloxy)phenylmethyl)carbamide (2 R ,3 R )-dihydroxybutanedioate (2:1) (ACP-103) are presented. A potent 5-hydroxytrypt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e7de0fc0198101248cda15fb4bff3cc
https://doi.org/10.1124/jpet.105.097006
https://doi.org/10.1124/jpet.105.097006
Autor:
Stefania Risso Bradley, Robert E. Davis, Tracy Spalding, Uli Hacksell, Kimberly E. Vanover, Malath Makhay, Carl-Magnus A. Andersson, Bo-Ragnar Tolf, Henriette Kold, Thomas Son, Isaac Veinbergs, Mark R. Brann, David M. Weiner, Scott C. Harvey
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 310:943-951
The primary purpose of the present series of experiments was to characterize the in vitro and in vivo pharmacology profile of 2-(4-methoxy-phenyl)-N-(4-methyl-benzyl)-N-(1-methyl-piperidin-4-yl)-acetamide hydrochloride (AC-90179), a selective seroton
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f03c393a0442791287ab5db3f9b886ec
https://doi.org/10.1124/jpet.104.066688
https://doi.org/10.1124/jpet.104.066688
Autor:
Leigh J. Hsu, Makoto Yoshimoto, Yu Xia, Isaac Veinbergs, Eliezer Masliah, Margaret Mallory, Makoto Hashimoto, Tsunao Saitoh, Leon J. Thal
Publikováno v:
Journal of Neurochemistry. 71:338-344
The non-Abeta component of Alzheimer's disease amyloid precursor protein (NACP) is predominantly a neuron-specific presynaptic protein that may play a central role in neurodegeneration because NACP fragments are found in Alzheimer's disease amyloid a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88565b9cceef40e0affbab5015408632
https://doi.org/10.1046/j.1471-4159.1998.71010338.x
https://doi.org/10.1046/j.1471-4159.1998.71010338.x
Autor:
Margaret Mallory, Christine McGiffert, M. Alford, Isaac Veinbergs, Richard DeTeresa, Emily Van Uden, Robert A. Orlando, Eliezer Masliah
Publikováno v:
Experimental Neurology. 170:15-26
Apolipoprotein E (apoE) is known to bind to at least five receptors, including the low-density lipoprotein (LDL) receptor-related protein (LRP), very low density LDL receptor (VLDL-R), LDL-R, apoE receptor 2 (apoER2), and megalin/gp330. In this conte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce442ea79441204ec59d77c5aeed7f7
https://doi.org/10.1006/exnr.2001.7684
https://doi.org/10.1006/exnr.2001.7684
Publikováno v:
European Journal of Neuroscience. 12:4541-4546
Recent studies have suggested that altered function of apolipoprotein E might lead to Alzheimer's disease via oxidative stress. In this context, the objective of this study was to determine if antioxidative treatment with vitamin E was neuroprotectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7e0e1cf89d0f85f1ac7e67a42694694
https://doi.org/10.1111/j.1460-9568.2000.01308.x
https://doi.org/10.1111/j.1460-9568.2000.01308.x
Autor:
Eliezer Masliah, Edward Rockenstein, John R Gilbert, Margaret Mallory, Isaac Veinbergs, Michael Mante
Publikováno v:
Neuroscience Letters. 265:218-222
The present study seeked to determine whether the neurodegenerative and cognitive alterations in aged apolipoprotein E-deficient mice are differentially reversed by transgenic overexpression of human apolipoprotein-E3 vs. apolipoprotein-E4 in the bac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582f5ed906dace77a8aadede4e209d64
https://doi.org/10.1016/s0304-3940(99)00243-8
https://doi.org/10.1016/s0304-3940(99)00243-8
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 23:519-531
1. 1. Aged apoE-deficient mice and age-matched controls were tested for cognitive alterations in the Morris water maze. 2. 2. Water maze results were correlated with in vivo electrophysiology and expression of the synaptic protein synaptotagmin (p65)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df8be4036c4c8ff6f00197e82bf0be7
https://doi.org/10.1016/s0278-5846(99)00013-5
https://doi.org/10.1016/s0278-5846(99)00013-5
Publikováno v:
Progress in Neurobiology. 50:493-503
Apolipoprotein E (apoE) is a 34 kDa protein that plays an important role in cholesterol transport, uptake and redistribution. Within the nervous system, apoE might be involved in maintaining synaptic integrity after injury and during aging. ApoE migh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d61aadce02d246c564acba150f6e57
https://doi.org/10.1016/s0301-0082(96)00038-x
https://doi.org/10.1016/s0301-0082(96)00038-x