Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Isaac T W Harley"'
Autor:
Bahram Namjou, Yizhao Ni, Isaac T W Harley, Iouri Chepelev, Beth Cobb, Leah C Kottyan, Patrick M Gaffney, Joel M Guthridge, Kenneth Kaufman, John B Harley
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115614 (2014)
UNLABELLED:To explore the potential influence of the polymorphic 8p23.1 inversion on known autoimmune susceptibility risk at or near BLK locus, we validated a new bioinformatics method that utilizes SNP data to enable accurate, high-throughput genoty
Externí odkaz:
https://doaj.org/article/0dfd226d636948cfad0433d4aa3e4eed
Autor:
Shizhong Han, Joel M Guthridge, Isaac T W Harley, Andrea L Sestak, Xana Kim-Howard, Kenneth M Kaufman, Bahram Namjou, Harshal Deshmukh, Gail Bruner, Luis R Espinoza, Gary S Gilkeson, John B Harley, Judith A James, Swapan K Nath
Publikováno v:
PLoS ONE, Vol 3, Iss 3, p e0001757 (2008)
Osteopontin (SPP1) is an important bone matrix mediator found to have key roles in inflammation and immunity. SPP1 genetic polymorphisms and increased osteopontin protein levels have been reported to be associated with SLE in small patient collection
Externí odkaz:
https://doaj.org/article/e291051d6aea40bc92ed01d7fb7fa7bc
Autor:
Karen Chau, Yanint Raksadawan, Kristen Allison, John A. Ice, Robert Hal Scofield, Iouri Chepelev, Isaac T. W. Harley
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14449 (2023)
SjD (Sjögren’s Disease) and SLE (Systemic Lupus Erythematosus) are similar diseases. There is extensive overlap between the two in terms of both clinical features and pathobiologic mechanisms. Shared genetic risk is a potential explanation of this
Externí odkaz:
https://doaj.org/article/c84397c4232746a98be978ac2dbeb41f
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Most B cells produced in the bone marrow have some level of autoreactivity. Despite efforts of central tolerance to eliminate these cells, many escape to periphery, where in healthy individuals, they are rendered functionally non-responsive to restim
Externí odkaz:
https://doaj.org/article/4370338b7f7a4396bc9acf797ffd2fae
Publikováno v:
Frontiers in Immunology. 13
Seropositivity for autoantibodies against multiple islet antigens is associated with development of autoimmune type 1 diabetes (T1D), suggesting a role for B cells in disease. The importance of B cells in T1D is indicated by the effectiveness of B ce
Autor:
Maureen Banach, Isaac T. W. Harley, Mary K. McCarthy, Cody Rester, Adonis Stassinopoulos, Ross M. Kedl, Thomas E. Morrison, John C. Cambier
Publikováno v:
Magnetochemistry; Volume 8; Issue 2; Pages: 23
The ongoing COVID-19 pandemic has had devastating health impacts across the globe. The development of effective diagnostics and therapeutics will depend on the understanding of immune responses to natural infection and vaccination to the causative ag
Autor:
Bergren W. Crute, Rachel Sheraden, Vanessa L. Ott, Isaac T. W. Harley, Andrew Getahun, John C. Cambier
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, Vol 11 (2020)
Among the areas of most impactful recent progress in immunology is the discovery of inhibitory receptors and the subsequent translation of this knowledge to the clinic. Although the original and canonical member of this family is FcγRIIB, more recen
Autor:
Valerie M. Harris, Kristi A. Koelsch, Biji T. Kurien, Isaac T. W. Harley, Jonathan D. Wren, John B. Harley, R. Hal Scofield
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology, Vol 10 (2019)
Background: Ninety percent of systemic lupus erythematosus (SLE) patients are women. X chromosome-dosage increases susceptibility to SLE and primary Sjögren's syndrome (pSS). Chromosome X open reading frame 21 (CXorf21) escapes X-inactivation and is
Autor:
Valerie M. Harris, Isaac T. W. Harley, Biji T. Kurien, Kristi A. Koelsch, Robert Hal Scofield
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology
Frontiers in Immunology
Background: CXorf21 and SLC15a4 both contain risk alleles for systemic lupus erythematosus (SLE) and Sjogren's syndrome (pSS). The former escapes X inactivation. Our group predicts specific endolysosomal-dependent immune responses are driven by the p
Autor:
Calvin C. Chan, Isaac T. W. Harley, Paul T. Pfluger, Aurelien Trompette, Traci E. Stankiewicz, Jessica L. Allen, Maria E. Moreno-Fernandez, Michelle S. M. A. Damen, Jarren R. Oates, Pablo C. Alarcon, Jessica R. Doll, Matthew J. Flick, Leah M. Flick, Joan Sanchez-Gurmaches, Rajib Mukherjee, Rebekah Karns, Michael Helmrath, Thomas H. Inge, Stuart P. Weisberg, Sünje J. Pamp, David A. Relman, Randy J. Seeley, Matthias H. Tschöp, Christopher L. Karp, Senad Divanovic
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Interactions between the immune system and adipose tissue contribute to the regulation of body weight, however, the underlying mechanisms remain incompletely understood. Here the authors dissect the role of two structurally and functionally similar i
Externí odkaz:
https://doaj.org/article/1874a0fdf3df440c914731f67be8205d