Zobrazeno 1 - 10
of 2 097
pro vyhledávání: '"Isaac T"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Unlike most adhesive bonds, biological catch bonds strengthen with increased tension. This characteristic is essential to specific receptor-ligand interactions, underpinning biological adhesion dynamics, cell communication, and mechanosensin
Externí odkaz:
https://doaj.org/article/e9ebdc34e0fb459197606738810d1775
Autor:
Yingzhao Jin, Isaac T Cheng, Dongze Wu, Xianfeng Yan, Sze-Lok Lau, Nga Sze Wong, Vivian W Hung, Ling Qin, Ryan Ka Lok Lee, James F Griffith, Cheuk-Chun Szeto, Ho So, Lai-Shan Tam
Publikováno v:
Therapeutic Advances in Musculoskeletal Disease, Vol 16 (2024)
Psoriatic arthritis (PsA) is a heterogeneous, chronic, inflammatory musculoskeletal disease that can lead to peripheral and axial damage and loss of function. A clear difference between PsA and other forms of inflammatory arthritis is the different f
Externí odkaz:
https://doaj.org/article/0b0ad7ea5ad247a8bbd584dc0e466fe1
Autor:
Corey J. Widman, Sestina Ventresca, Jillian Dietrich, Gwendolynne Elmslie, Hazel Smith, Gina Kaup, Aaron Wesley, Madeline Doenecke, Frederick E. Williams, Isaac T. Schiefer, John Ellis, William S. Messer Jr.
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-21 (2024)
Abstract Allosteric modulation of muscarinic acetylcholine receptors (mAChR) has been identified as a potential strategy for regulating cholinergic signaling in the treatment of various neurological disorders. Most positive allosteric modulators (PAM
Externí odkaz:
https://doaj.org/article/eb35867a132545b2a514bfdec8308288
Autor:
Briana Maktabi, Abigail Collins, Raihaanah Safee, Jada Bouyer, Alexander S. Wisner, Frederick E. Williams, Isaac T. Schiefer
Publikováno v:
Biomedicines, Vol 12, Iss 10, p 2354 (2024)
Background: Zebrafish have become a key model organism in neuroscience research because of their unique advantages. Their genetic, anatomical, and physiological similarities to humans, coupled with their rapid development and transparent embryos, mak
Externí odkaz:
https://doaj.org/article/4d51d2f4aac34de58cee9cd433180f84
Publikováno v:
Translation, Vol 12, Iss 3 (2024)
Externí odkaz:
https://doaj.org/article/96a2e7da4a1044fd96d91c97212f7fdc
Publikováno v:
South African Journal of Business Management, Vol 55, Iss 1, Pp e1-e13 (2024)
Purpose: This study examines the interplay of psychosocial career pre-occupation, social connectedness, and organisational commitment in higher education and offers insights for academia and practitioners. It also explores the impact of gender, job l
Externí odkaz:
https://doaj.org/article/cfeaa00f6e5b465cb548d2e47cbdf5a9
Autor:
Pathum M. Weerawarna, Isaac T. Schiefer, Pedro Soares, Susan Fox, Richard I. Morimoto, Rafael D. Melani, Neil L. Kelleher, Chi-Hao Luan, Richard B. Silverman
Publikováno v:
ACS Central Science, Vol 10, Iss 1, Pp 87-103 (2023)
Externí odkaz:
https://doaj.org/article/ba3032efe9234196b66de6d2dfb01321
Autor:
Millicent T. Akere, Kelsee K. Zajac, James D. Bretz, Anvitha R. Madhavaram, Austin C. Horton, Isaac T. Schiefer
Publikováno v:
Brain Sciences, Vol 14, Iss 8, p 770 (2024)
The ability to screen for agents that can promote the development and/or maintenance of neuronal networks creates opportunities for the discovery of novel agents for the treatment of central nervous system (CNS) disorders. Over the past 10 years, adv
Externí odkaz:
https://doaj.org/article/cf49b1417f33449ca774a991973e4471
Autor:
Yingzhao Jin, Isaac T Cheng, Ho So, Dongze Wu, James F Griffith, Vivian W Hung, Ling Qin, Cheuk-Chun Szeto, Agnes WS Chan, Lai-Shan Tam
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-10 (2023)
Abstract Background To investigate the relationship between disease-related parameters and joint space width (JSW) on high-resolution peripheral quantitative computed tomography (HR-pQCT) in psoriatic arthritis (PsA) patients. Methods PsA patients wh
Externí odkaz:
https://doaj.org/article/ed4dabb9a87d4afe8ad902475a015dc1
Publikováno v:
RMD Open, Vol 10, Iss 1 (2024)
Objectives To elucidate the association between different disease activity levels over time on long-term vascular outcomes in patients with early rheumatoid arthritis (ERA).Methods This was a 5-year prospective study. Patients with consecutive ERA wi
Externí odkaz:
https://doaj.org/article/8db643fd822c44d99faca727b81da646