Výsledky vyhledávání - "Isaac Snowhite"

Baseline Assessment of Circulating microRNAs Near Diagnosis of Type 1 Diabetes Predicts Future Stimulated Insulin Secretion

Autor: Shari Messinger Cayetano, Ricardo L. Pastori, Alberto Pugliese, Jay M. Sosenko, Isaac Snowhite

Publikováno v: Diabetes

Type 1 diabetes is an autoimmune disease resulting in severely impaired insulin secretion. We investigated whether circulating microRNAs (miRNAs) are associated with residual insulin secretion at diagnosis and predict the severity of its future decli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4571f5fd3951c3f206bcfc5548f922bb
https://doi.org/10.2337/figshare.13281188

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Baseline Assessment of Circulating microRNAs Near Diagnosis of Type 1 Diabetes Predicts Future Stimulated Insulin Secretion

Autor: Alberto Pugliese, Shari Messinger Cayetano, Jay Sosenko, Ricardo Pastori, Isaac Snowhite, Ada Admin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b93c66b07b0f105736a83071d8be207a
https://doi.org/10.2337/figshare.13281188.v1

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Association of serum microRNAs with islet autoimmunity, disease progression and metabolic impairment in relatives at risk of type 1 diabetes

Autor: Gloria Allende, Alberto Pugliese, Isaac Snowhite, Jay M. Sosenko, Shari Messinger Cayetano, Ricardo L. Pastori

Publikováno v: Diabetologia. 60:1409-1422

MicroRNAs (miRNAs) are key regulators of gene expression and novel biomarkers for many diseases. We investigated the hypothesis that serum levels of some miRNAs would be associated with islet autoimmunity and/or progression to type 1 diabetes. We mea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c91eb769c85b49ddff551a16c5d919
https://doi.org/10.1007/s00125-017-4294-3

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Risk Factors for Type 1 Diabetes Recurrence in Immunosuppressed Recipients of Simultaneous Pancreas–Kidney Transplants

Autor: L. Chen, J. C. Hutton, Alberto Pugliese, Isaac Snowhite, George W. Burke, Gaetano Ciancio, Shari Messinger, Stavros Diamantopoulos, Philip Ruiz, Y. Y. Hopfner, Gloria Allende, Francesco Vendrame, S. K. Virdi, Helena Reijonen

Publikováno v: American Journal of Transplantation

Patients with type 1 diabetes (T1D) who are recipients of pancreas transplants are believed to rarely develop T1D recurrence in the allograft if effectively immunosuppressed. We evaluated a cohort of 223 recipients of simultaneous pancreas–kidney a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcbfe42af6d026feea7806b17643c92c
https://doi.org/10.1111/ajt.13426

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MicroRNAs: markers of β-cell stress and autoimmunity

Autor: Isaac Snowhite, Alberto Pugliese, Giuliana Ventriglia, Francesco Dotta

We discuss current knowledge about microRNAs (miRNAs) in type 1 diabetes (T1D), an autoimmune disease leading to severe loss of pancreatic β-cells. We describe: the role of cellular miRNAs in regulating immune functions and pathways impacting insuli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac3e9baa2f52171ea914fb8e48e7c673
http://hdl.handle.net/11365/1055817

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Transcriptomes of antigen presenting cells in human thymus

Autor: Isaac Snowhite, H E Akselsen, Hanna Helgeland, Arvind Y. M. Sundaram, Siri Tennebø Flåm, Benedicte A. Lie, Ingvild Synnøve Matre Gabrielsen, Hans Christian Dalsbotten Aass, Alberto Pugliese

Publikováno v: PLoS ONE, Vol 14, Iss 7, p e0218858 (2019)
PLoS ONE

Antigen presenting cells (APCs) in the thymus play an essential role in the establishment of central tolerance, i.e. the generation of a repertoire of functional and self-tolerant T cells to prevent autoimmunity. In this study, we have compared the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4613ccd9df9a79fb8ff8347028925c
https://doi.org/10.1371/journal.pone.0218858

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Insulin2Gene (Ins2) Transcription by NOD Bone Marrow-derived Cells Does Not Influence Autoimmune Diabetes Development in NOD-Ins2Knockout Mice

Autor: Maki Nakayama, Ainhoa Martin-Pagola, Antonello Pileggi, R. Damaris Molano, Francesco Vendrame, Camillo Ricordi, George S. Eisenbarth, Isaac Snowhite, Alberto Pugliese, E. Zahr

Publikováno v: Scandinavian Journal of Immunology. 70:439-446

Insulin is a critical autoantigen for the development of autoimmune diabetes in non-obese diabetic (NOD) mice. About 80% of NOD females and 30-40% of NOD males develop diabetes. However, Insulin2 (Ins2) knockout NOD mice develop autoimmune diabetes w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff024eeb3c55bb94684207107824e65
https://doi.org/10.1111/j.1365-3083.2009.02316.x

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Selective IL-2 responsiveness of regulatory T cells through multiple intrinsic mechanisms supports the use of low-dose IL-2 therapy in type 1 diabetes

Autor: David Klatzmann, Thomas R. Malek, Aixin Yu, Francesco Vendrame, Isaac Snowhite, Michelle Rosenzwajg, Alberto Pugliese

Publikováno v: Diabetes

Low-dose interleukin-2 (IL-2) inhibited unwanted immune responses in several clinical settings and is currently being tested in patients with type 1 diabetes (T1D). Low-dose IL-2 selectively targets regulatory T cells (Tregs), but the mechanisms unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc7182b13986fc70696aed8a4e68776
https://pubmed.ncbi.nlm.nih.gov/25999537

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Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells

Publikováno v: Vendrame, F; Pileggi, A; Laughlin, E; Allende, G; Martin-Pagola, A; Molano, RD; et al.(2010). Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells. Diabetes, 59(4), 947-957. doi: 10.2337/db09-0498. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/6m79n86s
Diabetes

OBJECTIVE To investigate if recurrent autoimmunity explained hyperglycemia and C-peptide loss in three immunosuppressed simultaneous pancreas-kidney (SPK) transplant recipients. RESEARCH DESIGN AND METHODS We monitored autoantibodies and autoreactive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d65f8f5df65f046e8a0d8072bc34977
https://pubmed.ncbi.nlm.nih.gov/20640940

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Human regulatory T cells are hyper-responsive to low levels of IL-2 (P5156)

Autor: Thomas Malek, Axin Yu, Francesco Vendrame, Isaac Snowhite, Alberto Pugliese

Publikováno v: The Journal of Immunology. 190:195.7-195.7

Our recent work demonstrates that weak IL-2R signaling supports the development and homeostasis of mouse Treg cells. This finding provides a conceptual framework for the use of low dose IL-2 in immunotherapy to selectively promote Treg cells for tole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3fd1cc4f938c1b6feb399b677940f7f9
https://doi.org/10.4049/jimmunol.190.supp.195.7

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