Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Isaac Sipo"'
Autor:
Burkert Pieske, Yoshiaki Kawase, Egbert Bisping, Lahouaria Hadri, Henry Fechner, Volker A. Erdmann, Stefanie Krohn, Wolfgang Poller, Roland Vetter, Jens Kockskämper, Hung Q. Ly, Dirk Westermann, Jiqiu Chen, Lennart Suckau, Elie R. Chemaly, Heinz-Peter Schultheiss, Carsten Tschöpe, Djamel Lebeche, Lifan Liang, Isaac Sipo, Roger J. Hajjar, Jens Kurreck, Stefan Weger, Xiaomin Wang
Publikováno v:
Circulation. 119:1241-1252
Background— RNA interference (RNAi) has the potential to be a novel therapeutic strategy in diverse areas of medicine. Here, we report on targeted RNAi for the treatment of heart failure, an important disorder in humans that results from multiple c
Autor:
Sandra Pinkert, Wolfgang Poller, Volker A. Erdmann, Isaac Sipo, Heinz Zeichhardt, Dirk Westermann, Roland Vetter, Oliver J. Müller, Jens Kurreck, Lennart Suckau, Carsten Tschöpe, Henry Fechner, Xiaomin Wang
Publikováno v:
Journal of Molecular Medicine. 86:987-997
RNA interference (RNAi) has potential to be a novel therapeutic strategy in diverse areas of medicine. In this paper, we report on targeted RNAi for the treatment of a viral cardiomyopathy, which is a major cause of sudden cardiac death or terminal h
Autor:
Sandra Pinkert, Isaac Sipo, Stefan Weger, Wolfgang Poller, Henry Fechner, Xiaomin Wang, Lennart Suckau
Publikováno v:
Gene Therapy. 14:1319-1329
Recently it was shown that several new pseudotyped adeno-associated virus (AAV) vectors support cardioselective expression of transgenes. The molecular mechanisms underlying this propensity for cardiac cell transduction are not well understood. We co
Autor:
Sandra Pinkert, Roland Vetter, Heinz P. Schultheiss, Hans-Peter Grunert, Heinz Zeichhardt, Wolfgang Poller, Jens Kurreck, Lennart Suckau, Isaac Sipo, Sollerbrant K, Xiaomin Wang, Andrea Dörner, Henry Fechner
Publikováno v:
Gene Therapy
As coxsackievirus B3 (CoxB3) and adenoviruses may cause acute myocarditis and inflammatory cardiomyopathy, isolation of the common coxsackievirus–adenovirus-receptor (CAR) has provided an interesting new target for molecular antiviral therapy. Wher
Autor:
Henry Fechner, Wolfgang Poller, Almudena Hurtado Picó, Judith Wildner, Xiaomin Wang, Isaac Sipo, Stefan Weger, Sandra Pinkert, Lennart Suckau
Publikováno v:
Journal of Biotechnology. 127:560-574
Tight regulation of oncolytic adenoviruses (oAdV) represents an important requirement for their safe application. Here we describe a new doxycycline (Dox)-dependent oAdV with a bidirectional expression cassette, which drives the expression of the rev
Autor:
S. Loschen, Heinz-Peter Schultheiss, Isaac Sipo, Jos M. J. Lamers, Volker A. Erdmann, Dick H. W. Dekkers, Stefan Weger, Sandra Pinkert, Roland Vetter, Martin Paul, Henry Fechner, Jens Kurreck, Lennart Suckau, Wolfgang Poller, J. Rekittke, Xiaomin Wang
Publikováno v:
Gene Therapy. 14:211-218
Impaired function of the phospholamban (PLB)-regulated sarcoplasmic reticulum Ca(2+) pump (SERCA2a) contributes to cardiac dysfunction in heart failure (HF). PLB downregulation may increase SERCA2a activity and improve cardiac function. Small interfe
Autor:
Wolfgang Poller, Henry Fechner, Almudena Hurtado Picó, Ulrike Siemetzki, Isaac Sipo, Jürgen Eberle, Xiaomin Wang
Publikováno v:
Molecular Therapy. 11(4):563-577
Restricted replication-competent adenoviruses (RRCAs) using tumor- and tissue-specific promoters (ttsP's) are new tools for cancer gene therapy. In this study we investigated viral and nonviral factors affecting "leakiness" of several ttsP's and thei
Autor:
Isaac Sipo, Oliver Planz, Mathias Knauf, Stephen Norley, Reinhard Kurth, Wolfgang Poller, Henry Fechner
Publikováno v:
Vaccine. 29(8)
The recent H1N1 influenza pandemic and the inevitable delay between identification of the virus and production of the specific vaccine have highlighted the urgent need for new generation influenza vaccines that can preemptively induce broad immunity
Autor:
Wolfgang Poller, Isaac Sipo, Dirk Westermann, Jens Kurreck, Roland Vetter, Xiaomin Wang, Lennart Suckau, Heinz Zeichhardt, Sandra Pinkert, Volker Erdmann, Carsten Tschope, Henry Fechner
Publikováno v:
Circulation. 118
RNA interference (RNAi) has potential to be a novel therapeutic strategy in diverse areas of medicine. We report here on targeted RNAi for the treatment of a viral cardiomyopathy which is a major cause of sudden cardiac death or terminal heart failur
Autor:
Volker A. Erdmann, Isaac Sipo, Diana Rothe, Heinz Zeichhardt, Jens Kurreck, W. Poller, Steffen Schubert, Henry Fechner, Denise Werk, Hans-Peter Grunert
Publikováno v:
Web of Science
Retrovirology
ResearcherID
Retrovirology
ResearcherID
Here, we demonstrate the potential of RNAi to inhibit a picornavirus, coxsackievirus B3 (CVB3), a major causes of myocardial diseases. Targeting the 3D RNA dependent RNA polymerase (RdRP) with virus specific small interfering RNAs (siRNAs) resulted i