Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Isaac Shamie"'
Autor:
Erick Armingol, Abbas Ghaddar, Chintan J Joshi, Hratch Baghdassarian, Isaac Shamie, Jason Chan, Hsuan-Lin Her, Samuel Berhanu, Anushka Dar, Fabiola Rodriguez-Armstrong, Olivia Yang, Eyleen J O'Rourke, Nathan E Lewis
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 11, p e1010715 (2022)
Cell-cell interactions shape cellular function and ultimately organismal phenotype. Interacting cells can sense their mutual distance using combinations of ligand-receptor pairs, suggesting the existence of a spatial code, i.e., signals encoding spat
Externí odkaz:
https://doaj.org/article/fbf28cea235048f493ac6e76bf2459d1
Autor:
Abdulwahab Alasfour, Paolo Gabriel, Xi Jiang, Isaac Shamie, Lucia Melloni, Thomas Thesen, Patricia Dugan, Daniel Friedman, Werner Doyle, Orin Devinsky, David Gonda, Shifteh Sattar, Sonya Wang, Eric Halgren, Vikash Gilja
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 8, p e1010401 (2022)
In analyzing the neural correlates of naturalistic and unstructured behaviors, features of neural activity that are ignored in a trial-based experimental paradigm can be more fully studied and investigated. Here, we analyze neural activity from two p
Externí odkaz:
https://doaj.org/article/a1b01a5f3d0345a5a03b097f8a15bd40
Autor:
Benjamin P. Kellman, Hratch M. Baghdassarian, Tiziano Pramparo, Isaac Shamie, Vahid Gazestani, Arjana Begzati, Shangzhong Li, Srinivasa Nalabolu, Sarah Murray, Linda Lopez, Karen Pierce, Eric Courchesne, Nathan E. Lewis
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-15 (2021)
Abstract Background Both RNA-Seq and sample freeze-thaw are ubiquitous. However, knowledge about the impact of freeze-thaw on downstream analyses is limited. The lack of common quality metrics that are sufficiently sensitive to freeze-thaw and RNA de
Externí odkaz:
https://doaj.org/article/405f1635944c43af9e02eeabec735f15
Correction: StanDep: Capturing transcriptomic variability improves context-specific metabolic models
Autor:
Chintan J. Joshi, Song-Min Schinn, Anne Richelle, Isaac Shamie, Eyleen J. O’Rourke, Nathan E. Lewis
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/fef12c4dfdea40bcb2e98d661e43b01a
Autor:
Chintan J Joshi, Song-Min Schinn, Anne Richelle, Isaac Shamie, Eyleen J O'Rourke, Nathan E Lewis
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 5, p e1007764 (2020)
Diverse algorithms can integrate transcriptomics with genome-scale metabolic models (GEMs) to build context-specific metabolic models. These algorithms require identification of a list of high confidence (core) reactions from transcriptomics, but par
Externí odkaz:
https://doaj.org/article/17ea3e8debd54f5aba41d0f79dd8fd1b
Autor:
Giri P Krishnan, Sylvain Chauvette, Isaac Shamie, Sara Soltani, Igor Timofeev, Sydney S Cash, Eric Halgren, Maxim Bazhenov
Publikováno v:
eLife, Vol 5 (2016)
The link between the combined action of neuromodulators in the brain and global brain states remains a mystery. In this study, using biophysically realistic models of the thalamocortical network, we identified the critical intrinsic and synaptic mech
Externí odkaz:
https://doaj.org/article/e68e5fcf9e354911882188c4785953c5
Autor:
Michelle Dilley, Lauren Loop, Ben Croker, Seema Aceves, Nathan Lewis, Yanfang Zhu, Jamie Lee, Isaac Shamie, Austin Chiang, Anoushka Tambay, Bob Geng
Publikováno v:
Journal of Allergy and Clinical Immunology. 151:AB219
Autor:
Gyun Min Lee, Isaac Shamie, Kai Xiong, Sascha H. Duttke, Hooman Hefzi, Claudia Z. Han, Jenhan Tao, Shangzhong Li, Karen Julie la Cour Karottki, Anders Holmgaard Hansen, Christopher Benner, Samuel J. Roth, Helene Faustrup Kildegaard, Christopher K. Glass, Nathan E. Lewis
Publikováno v:
NAR genomics and bioinformatics, vol 3, iss 3
Shamie, I, Duttke, S H, Karottki, KJC, Han, C Z, Hansen, AH, Hefzi, H, Xiong, K, Li, S, Roth, SJ, Tao, J, Lee, GM, Glass, CK, Kildegaard, HF, Benner, C & Lewis, NE 2021, ' A Chinese hamster transcription start site atlas that enables targeted editing of CHO cells ', NAR Genomics and Bioinformatics, vol. 3, no. 3 . https://doi.org/10.1093/nargab/lqab061
NAR Genomics and Bioinformatics
Shamie, I, Duttke, S H, Karottki, KJC, Han, C Z, Hansen, AH, Hefzi, H, Xiong, K, Li, S, Roth, SJ, Tao, J, Lee, GM, Glass, CK, Kildegaard, HF, Benner, C & Lewis, NE 2021, ' A Chinese hamster transcription start site atlas that enables targeted editing of CHO cells ', NAR Genomics and Bioinformatics, vol. 3, no. 3 . https://doi.org/10.1093/nargab/lqab061
NAR Genomics and Bioinformatics
Chinese hamster ovary (CHO) cells are widely used for producing biopharmaceuticals, and engineering gene expression in CHO is key to improving drug quality and affordability. However, engineering gene expression or activating silent genes requires ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b330ccae0af79fc4c7a23ab93f82ec4e
https://escholarship.org/uc/item/6cn1b1j4
https://escholarship.org/uc/item/6cn1b1j4
Autor:
Srinivasa Nalabolu, Tiziano Pramparo, Benjamin P. Kellman, Vahid H. Gazestani, Eric Courchesne, Sarah S. Murray, Shangzhong Li, Hratch M. Baghdassarian, Arjana Begzati, Karen Pierce, Nathan E. Lewis, Isaac Shamie, Linda Lopez
Publikováno v:
BMC Genomics
BMC genomics, vol 22, iss 1
BMC Genomics, Vol 22, Iss 1, Pp 1-15 (2021)
BMC genomics, vol 22, iss 1
BMC Genomics, Vol 22, Iss 1, Pp 1-15 (2021)
Background Both RNA-Seq and sample freeze-thaw are ubiquitous. However, knowledge about the impact of freeze-thaw on downstream analyses is limited. The lack of common quality metrics that are sufficiently sensitive to freeze-thaw and RNA degradation
Autor:
Alessandra Franco, Elizabeth Moreno, Hal M. Hoffman, Weiqi Peng, Isaac Shamie, John T. Kanegaye, Stephanie G. Labou, Cameron J. Nowell, Jane C. Burns, Eric R. Griffis, Ben A. Croker, Chisato Shimizu, Linh N.N. Le, Adriana H. Tremoulet, Lori Broderick, Yanfang Peipei Zhu, Huilai Miao, Hainan Xiong, Yushan Liu, Shiela Angulo, Nathan E. Lewis, Jamie Casey Lee, Cathleen J. Pena
Publikováno v:
Cell Reports Medicine
BACKGROUNDMultisystem inflammatory syndrome in children (MIS-C) is a rare but potentially severe illness that follows exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Kawasaki disease (KD) shares several clinical features wit