Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Isaac S, Harris"'
Autor:
Gloria Asantewaa, Emily T. Tuttle, Nathan P. Ward, Yun Pyo Kang, Yumi Kim, Madeline E. Kavanagh, Nomeda Girnius, Ying Chen, Katherine Rodriguez, Fabio Hecht, Marco Zocchi, Leonid Smorodintsev-Schiller, TashJaé Q. Scales, Kira Taylor, Fatemeh Alimohammadi, Renae P. Duncan, Zachary R. Sechrist, Diana Agostini-Vulaj, Xenia L. Schafer, Hayley Chang, Zachary R. Smith, Thomas N. O’Connor, Sarah Whelan, Laura M. Selfors, Jett Crowdis, G. Kenneth Gray, Roderick T. Bronson, Dirk Brenner, Alessandro Rufini, Robert T. Dirksen, Aram F. Hezel, Aaron R. Huber, Joshua Munger, Benjamin F. Cravatt, Vasilis Vasiliou, Calvin L. Cole, Gina M. DeNicola, Isaac S. Harris
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Cells rely on antioxidants to survive. The most abundant antioxidant is glutathione (GSH). The synthesis of GSH is non-redundantly controlled by the glutamate-cysteine ligase catalytic subunit (GCLC). GSH imbalance is implicated in many dise
Externí odkaz:
https://doaj.org/article/8f2b42686a084979a860c07d826515fd
Autor:
Matthew H. Raymonda, Irene Rodríguez-Sánchez, Xenia L. Schafer, Leonid Smorodintsev-Schiller, Isaac S. Harris, Joshua Munger
Publikováno v:
mBio, Vol 15, Iss 1 (2024)
ABSTRACTHuman cytomegalovirus (HCMV) modulates cellular metabolism to support productive infection, and the HCMV UL38 protein drives many aspects of this HCMV-induced metabolic program. However, it remains to be determined whether virally induced met
Externí odkaz:
https://doaj.org/article/cbe99c7ea6ee460c98c222d77ae4b014
Autor:
Barry M. Zee, Kamrine E. Poels, Cong-Hui Yao, Kimihito C. Kawabata, Gongwei Wu, Cihangir Duy, William D. Jacobus, Elizabeth Senior, Jennifer E. Endress, Ashwini Jambhekar, Scott B. Lovitch, Jiexian Ma, Abhinav Dhall, Isaac S. Harris, M. Andres Blanco, David B. Sykes, Jonathan D. Licht, David M. Weinstock, Ari Melnick, Marcia C. Haigis, Franziska Michor, Yang Shi
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102651- (2021)
Summary: A hallmark of acute myeloid leukemia (AML) is the inability of self-renewing malignant cells to mature into a non-dividing terminally differentiated state. This differentiation block has been linked to dysregulation of multiple cellular proc
Externí odkaz:
https://doaj.org/article/df9a6accf7904e598158db5f5e73b10a
Autor:
Matthew H. Raymonda, Irene Rodríguez-Sánchez, Xenia L. Schafer, Leonid Smorodintsev-Schiller, Isaac S. Harris, Joshua Munger
Publikováno v:
bioRxiv
Human cytomegalovirus (HCMV) modulates cellular metabolism to support productive infection, and the HCMV UL38 protein drives many aspects of this HCMV-induced metabolic program. However, it remains to be determined whether virally-induced metabolic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb1e2e3452428b05da984b2138cf4d54
https://doi.org/10.1101/2023.05.17.541212
https://doi.org/10.1101/2023.05.17.541212
Autor:
Arlene H. Sharpe, Marcia C. Haigis, Justin D. Trombley, Vikram R. Juneja, Kiran Kurmi, Cong-Hui Yao, Alison E. Ringel, Martin W. LaFleur, Isaac S. Harris, Emily F. Gaudiano, Thao H. Nguyen, Tara Muijlwijk, Jacob E. Gillis, Jefte M. Drijvers
Supplementary Figure and Table Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5626481bdf20fe17e9420d14ae280ac8
https://doi.org/10.1158/2326-6066.22543842.v1
https://doi.org/10.1158/2326-6066.22543842.v1
Autor:
Arlene H. Sharpe, Marcia C. Haigis, Justin D. Trombley, Vikram R. Juneja, Kiran Kurmi, Cong-Hui Yao, Alison E. Ringel, Martin W. LaFleur, Isaac S. Harris, Emily F. Gaudiano, Thao H. Nguyen, Tara Muijlwijk, Jacob E. Gillis, Jefte M. Drijvers
Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ed5bd45f25fdeb87ae7c177752dece
https://doi.org/10.1158/2326-6066.22543839.v1
https://doi.org/10.1158/2326-6066.22543839.v1
Autor:
Arlene H. Sharpe, Marcia C. Haigis, Justin D. Trombley, Vikram R. Juneja, Kiran Kurmi, Cong-Hui Yao, Alison E. Ringel, Martin W. LaFleur, Isaac S. Harris, Emily F. Gaudiano, Thao H. Nguyen, Tara Muijlwijk, Jacob E. Gillis, Jefte M. Drijvers
Supplementary Table S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d3ee59855a43f56797cd02ff8922fe4
https://doi.org/10.1158/2326-6066.22543836.v1
https://doi.org/10.1158/2326-6066.22543836.v1
Autor:
Arlene H. Sharpe, Marcia C. Haigis, Justin D. Trombley, Vikram R. Juneja, Kiran Kurmi, Cong-Hui Yao, Alison E. Ringel, Martin W. LaFleur, Isaac S. Harris, Emily F. Gaudiano, Thao H. Nguyen, Tara Muijlwijk, Jacob E. Gillis, Jefte M. Drijvers
All dose-response curves. Dose-response curves for all library compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe0979e1b7484e2e9469ad43c6a3357
https://doi.org/10.1158/2326-6066.22543845.v1
https://doi.org/10.1158/2326-6066.22543845.v1
Autor:
Arlene H. Sharpe, Marcia C. Haigis, Justin D. Trombley, Vikram R. Juneja, Kiran Kurmi, Cong-Hui Yao, Alison E. Ringel, Martin W. LaFleur, Isaac S. Harris, Emily F. Gaudiano, Thao H. Nguyen, Tara Muijlwijk, Jacob E. Gillis, Jefte M. Drijvers
Metabolic constraints in the tumor microenvironment constitute a barrier to effective antitumor immunity and similarities in the metabolic properties of T cells and cancer cells impede the specific therapeutic targeting of metabolism in either popula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4c0136f14266cee38042c4d6aaa2846
https://doi.org/10.1158/2326-6066.c.6550425.v1
https://doi.org/10.1158/2326-6066.c.6550425.v1
Autor:
Gloria Asantewaa, Emily T. Tuttle, Nathan P. Ward, Yun Pyo Kang, Yumi Kim, Madeline E. Kavanagh, Nomeda Girnius, Ying Chen, Renae Duncan, Katherine Rodriguez, Fabio Hecht, Marco Zocchi, Leonid Smorodintsev-Schiller, TashJaé Q. Scales, Kira Taylor, Fatemeh Alimohammadi, Zachary R Sechrist, Diana Agostini-Vulaj, Xenia L. Schafer, Hayley Chang, Zachary Smith, Thomas N. O’Connor, Sarah Whelan, Laura M. Selfors, Jett Crowdis, G. Kenneth Gray, Roderick T. Bronson, Dirk Brenner, Alessandro Rufini, Robert T. Dirksen, Aram F. Hezel, Aaron R. Huber, Josh Munger, Benjamin F. Cravatt, Vasilis Vasiliou, Calvin L Cole, Gina M. DeNicola, Isaac S. Harris
Publikováno v:
bioRxiv
SUMMARYCells rely on antioxidants to survive. The most abundant antioxidant is glutathione (GSH). The synthesis of GSH is non-redundantly controlled by the glutamate-cysteine ligase catalytic subunit (GCLC). GSH imbalance is implicated in many diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::050d9ff233a55d85b41263e9d027715f
https://europepmc.org/articles/PMC9934595/
https://europepmc.org/articles/PMC9934595/