Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Isaac R. Kasper"'
Autor:
Camilo E. Fadul, Kathleen A. Ryan, Isaac R. Kasper, Daniel W. Mielcarz, Heather A. Wishart, Brant Oliver, Lloyd H. Kasper, Randolph J. Noelle, Jacqueline Y. Channon, Yang Mao-Draayer
Publikováno v:
Neurology® Neuroimmunology & Neuroinflammation
article-version (Version of Record) 3
article-version (Version of Record) 3
Background and ObjectivesCostimulation by CD40 and its ligand CD40L (CD154) is important for the functional differentiation of T cells. Preclinical studies have recognized the importance of this costimulatory interaction in the pathogenesis of experi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857afc870a8f1bfdf990ab507464464f
https://doi.org/10.1212/nxi.0000000000001096
https://doi.org/10.1212/nxi.0000000000001096
Autor:
Amir Sharabi, Hao Li, Vaishali R. Moulton, Maria Tsokos, Wen Liang Pan, Isaac R. Kasper, Esra Meidan, George C. Tsokos
Publikováno v:
JCI Insight. 4
Tregs require IL-2 signaling for signal transducer and activator of transcription 5–mediated (STAT5-mediated) induction of Foxp3. Although phosphatase 2A (PP2A) is a negative regulator of IL-2 production in effector T cells and Tregs do not produce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f92eaa4167bf7459cabede95c5b3fd
https://doi.org/10.1172/jci.insight.126294
https://doi.org/10.1172/jci.insight.126294
Publikováno v:
Clinical immunology (Orlando, Fla.). 186
Protein phosphatase 2A (PP2A) is the first serine/threonine phosphatase recognized to contribute to human and murine lupus immunopathology. PP2A expression in SLE is controlled both epigenetically and genetically, and it is increased in patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f37b8e7c29eb64eb6c601a00bb666c3
https://pubmed.ncbi.nlm.nih.gov/28736280
https://pubmed.ncbi.nlm.nih.gov/28736280
Autor:
Lloyd H. Kasper, Sakhina Begum-Haque, Isaac R. Kasper, Alok Sharma, Daniel Mielcarz, David M. Foureau, Azizul Haque
Publikováno v:
Journal of Neuroimmunology. 204:58-65
T helper 17 (Th17) cells are pivotal in the immune pathogenesis of EAE. Glatiramer acetate (GA) can enhance Treg FOXp3 expression. We demonstrate that GA downregulates the expression of both IL-17 and IL-6 in two different EAE models. Increased mRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::863bf2adba87e0b7b5e06eaaab0f3518
https://doi.org/10.1016/j.jneuroim.2008.07.018
https://doi.org/10.1016/j.jneuroim.2008.07.018