Surface functionalisation-dependent adverse effects of metal nanoparticles and nanoplastics in zebrafish embryos

Autor: Masanari Takamiya, Dorit Mattern, Juliane Rapp, Isaac Ojea-Jiménez, Silvia Diabaté, Marie-France A. Belinga-Desaunay-Nault, Abdullah O. Khan, Iseult Lynch, Chantal Anders, Selina V. Y. Ambrose, Luisa Reiner, Giuseppina Pace, Iris Hansjosten, Uwe Strähle, I.-Lun Hsiao, Ravindra Peravali, Thomas Dickmeis, Susanne Fritsch-Decker, Douglas Gilliland, Silvia Andraschko, Eugenia Valsami-Jones, Carsten Weiss, Sepand Rastegar

Publikováno v: Environmental Science: Nano. 9:375-392

The growing number of manufactured nanomaterials (MNMs) used in consumer products and industrial applications is leading to increased exposures whose consequences are not yet fully understood in terms of potential impacts on human and ecosystem healt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7a2b018b2ffc420438985fa5b75ed13
https://doi.org/10.1039/d1en00299f

Rational design of multi-functional gold nanoparticles with controlled biomolecule adsorption: a multi-method approach for in-depth characterization

Autor: Robin Capomaccio, Isaac Ojea-Jiménez, Inês Osório, Douglas Gilliland, Dora Mehn, Luigi Calzolai, Rohanah Hussain, François Rossi, Giacomo Ceccone, Giuliano Siligardi, Pascal Colpo

Publikováno v: Nanoscale. 10:10173-10181

Multi-functionalized nanoparticles are of great interest in biotechnology and biomedicine, especially for diagnostic and therapeutic purposes. However, at the moment the characterization of complex, multi-functional nanoparticles is still challenging

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543fdb57fad6929aa096f3d3ce0753f4
https://doi.org/10.1039/c8nr00973b

Structural and Thermodynamic Properties of Nanoparticle–Protein Complexes: A Combined SAXS and SANS Study

Autor: Claudio Ferrero, Sophie Combet, Francesco Spinozzi, Giacomo Ceccone, Isaac Ojea-Jiménez, Gabriele Campanella, Paolo Moretti, Paolo Ghigna

Publikováno v: Langmuir. 33:2248-2256

We propose a novel method for determining the structural and thermodynamic properties of nanoparticle-protein complexes under physiological conditions. The method consists of collecting a full set of small-angle X-ray and neutron-scattering measureme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2deedbc398651864d391cedf19769c0c
https://doi.org/10.1021/acs.langmuir.6b04072

Differential Nanoparticle Sequestration by Macrophages and Scavenger Endothelial Cells Visualized in Vivo in Real-Time and at Ultrastructural Resolution

Autor: Kasper Kjaer-Sorensen, Pia Jensen, Hélicia Claude, Carsten Weiss, Clemens Grabher, Yuya Hayashi, Thomas Boesen, Uwe Strähle, Claude Antony, Isaac Ojea-Jiménez, Masanari Takamiya, Douglas Gilliland, Claus Oxvig

Publikováno v: Hayashi, Y, Takamiya, M, Jensen, P B, Ojea-Jiménez, I, Claude, H, Antony, C, Kjaer-Sorensen, K, Grabher, C, Boesen, T, Gilliland, D, Oxvig, C, Strähle, U & Weiss, C 2020, ' Differential Nanoparticle Sequestration by Macrophages and Scavenger Endothelial Cells Visualized i n Vivo in Real-Time and at Ultrastructural Resolution ', ACS Nano, vol. 14, no. 2, pp. 1665-1681 . https://doi.org/10.1021/acsnano.9b07233

Despite the common knowledge that the reticuloendothelial system is largely responsible for blood clearance of systemically administered nanoparticles, the sequestration mechanism remains a "black box". Using transgenic zebrafish embryos with cell ty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfbd400b3d6e3dbf8be86732b577626
https://pure.au.dk/portal/da/publications/differential-nanoparticle-sequestration-by-macrophages-and-scavenger-endothelial-cells-visualized-in-vivo-in-realtime-and-at-ultrastructural-resolution(e9ef0799-9f50-4a9e-8e24-da05fa64678a).html

A high throughput imaging database of toxicological effects of nanomaterials tested on HepaRG cells

Autor: Maurice Whelan, Iseult Lynch, Taina Palosaari, Sophie Marie Briffa, Isabella Römer, Douglas Gilliland, Isaac Ojea-Jiménez, Eugenia Valsami-Jones, Jean-Michel Gineste, Salvador Fortaner Torrent, Jaroslav Novak, Peter Macko, Elisabeth Joossens, Kirsten Gerloff

Publikováno v: Scientific Data, Vol 6, Iss 1, Pp 1-10 (2019)

The large amount of existing nanomaterials demands rapid and reliable methods for testing their potential toxicological effect on human health, preferably by means of relevant in vitro techniques in order to reduce testing on animals. Combining high

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aaf6b45fd903c2f20faa3f8f74ad5c5
https://doi.org/10.1038/s41597-019-0053-2